摘要
BCL-2 antibody recognizes BCL-2 protein. BCL-2 (26 kDa) regulates mitochondrial dynamics, is involved in the regulation of mitochondrial fusion and fission, and is associated with apoptosis. Abnormal expression of BCL-2 protein is linked to various cancers, autoimmunity, and psychiatric disorders. This BCL-2 antibody is a widely published rabbit polyclonal validated for multiple applications.
形式
Liquid
存储溶液
PBS, 1% BSA, 20% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Bcl-2. The exact sequence is proprietary.
纯化方式
Purified by antigen-affinity chromatography.
偶联
Unconjugated
RRID
AB_2036326
注意事项
仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。
别名
BCL2 apoptosis regulator , Bcl-2 , PPP1R50
细胞定位
Mitochondrion outer membrane , Nucleus membrane , Endoplasmic reticulum membrane
功能与背景
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq]
数据库
研究领域