形式
Liquid
存储溶液
PBS, 2% BSA
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
batch dependent
免疫原种属
Human
免疫原
Recombinant fragmemt of human CBP
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
CREB binding protein,CBP,KAT3A,MKHK1,RSTS,RSTS1
细胞定位
Cytoplasm,Nucleus
功能与背景
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
数据库
研究领域
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/small/GTX639943/GTX639943_20240408_IHC-P_2_24040801_722.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/small/GTX639943/GTX639943_20240408_IHC-P_1_24040801_553.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/small/GTX639943/GTX639943_20240408_IHC-P_24040801_477.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/normal/GTX639943/GTX639943_20240408_IHC-P_2_24040801_722.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/normal/GTX639943/GTX639943_20240408_IHC-P_1_24040801_553.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
![Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943](/upload/website/prouct_img/normal/GTX639943/GTX639943_20240408_IHC-P_24040801_477.webp "Anti-CBP antibody [HMV319] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639943")
