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beta Amyloid

beta-Amyloid antibody

Conformation-specific beta-Amyloid antibody for Alzheimer's disease research

 

Alzheimer’s disease (AD) pathogenesis is widely believed to be driven by the production and deposition of neurotoxic β-Amyloid peptide (Aβ) aggregates that form plaques in the brain. The Aβ molecules are generated from Amyloid Precursor Protein (APP) via β- and γ- secretase cleavage to produce Aβ monomers. Most of the Aβ peptides are 40 amino acids in length (Aβ 1-40, Aβ40), with a small percentage containing 42 residues (Aβ 1-42, Aβ42). These additional two C-terminal amino acids in Aβ42 confer a greater tendency to misfold and subsequently aggregate. Thus, Aβ42 is considered to be more neurotoxic than Aβ40.

GeneTex’s “beta-Amyloid (1-42) antibody – Conformation-Specific (GTX134510)” against Aβ 1-42 oligomers can specifically detect amyloid plaques in the AD brain by IHC-P analysis. The superior specificity and sensitivity of GTX134510 were confirmed by dot blot and side-by-side IHC-P comparison.

beta-Amyloid (1-42) antibody – Conformation-Specific (GTX134510)

       
  •   Human Aβ (1-42) oligomer immunogen
  •   Validated for dot blot, IHC-P, and ELISA
  •   High affinity and specificity
  •   Low background staining
  •   Detects beta-Amyloid aggregates in human AD brain tissue by IHC-P
  •   Detects beta-Amyloid aggregates in mouse AD model brain tissue by IHC-P

 

Dot blot analysis of beta-Amyloid peptide (1-42) oligomers or monomers, using beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510).

beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) detects beta-Amyloid plaques by IHC-P analysis in occipital lobe tissue from a brain with Alzheimer's disease, but not in normal human brain tissue.

beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) detects beta-Amyloid plaques by IHC-P analysis in hippocampal tissue from a 3xTg-AD transgenic mouse brain.

Side-by-side IHC-P comparison of two conformation-specific beta-Amyloid antibodies in occipital lobe (left) or postcentral gyrus (right) tissues from human brains with Alzheimer's disease (1:500 dilution). Only GeneTex’s beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) is able to detect beta-Amyloid plaques in the samples.