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2020诺奖-丙型肝炎病毒研究的重大意义

     2020年诺贝尔生理学或医学奖揭晓了!由Harvey J Alter与Michael Houhgton以及 Charles M Rice获得这一奖项,以表彰他们在血源性肝炎的战争中做出了决定性的贡献,血源性肝炎是导致世界各地人们肝硬化和肝癌的主要全球性健康问题。Harvey J Alter与Michael Houhgton以及 Charles M Rice做出了开创性的发现,从而鉴定出一种新型病毒,即丙型肝炎病毒,丙型肝炎的发现揭示了甲型和乙型肝炎以外的慢性肝炎病例的病因,并使血液检测和新药成为可能,挽救了数百万人的生命。

      丙型肝炎病毒(HCV)于1989年首次被发现,它影响着超过1亿7千万人,几乎有3%的世界人口对抗HCV抗体呈血清反应阳性,慢性感染发生在80-85%的急性感染中,可能导致肝硬化、肝衰竭、肝细胞癌(HCC)和死亡,HCV属于黄病毒科,具有具有正链单链RNA基因组,可编码3011个氨基酸的多蛋白,该多蛋白随后被病毒和细胞蛋白酶加工成三个结构蛋白(核心、E1和E2)和七个非结构蛋白(p7、NS2、NS3、NS4A、NS4B、NS5A和NS5B),尽管遗传多样性使HCV高度适应宿主免疫系统和抗病毒药物的挑战,但对HCV生物学的研究揭示了针对特定抗病毒疗法的新靶标(例如NS5B聚合酶和NS3蛋白酶),这为HCV感染者带来了新希望。

      Harvey J Alter进行的输血相关性肝炎的方法研究表明,未知病毒是导致慢性肝炎的常见原因,Michael Houhgton使用未经测试的策略来分离名为C型肝炎病毒的新病毒基因组,Charles M Rice提供了最后证据,证明C型肝炎病毒即可引起肝炎。诺贝尔奖获得者发现的丙型肝炎病毒是正在进行的与病毒性疾病斗争的里程碑式成就,由于他们的发现,现在可以对该病毒进行高度敏感的血液检查,并且这些检查基本上已经消除了世界许多地方的输血后肝炎,从而大大的改善了全球健康状况,他们的发现还针对丙型肝炎的抗病毒药物得以快速发展,历史上首次可以治愈该病,这为从世界人口中根除丙型肝炎病毒带来了希望,为了实现这一目标,将需要更多努力来促进血液检测和在全球范围内提供抗病毒药物。

  

热门研究产品

citation-support

Hepatitis C Virus Core Antigen antibody (GTX131265)

 

Hepatitis C virus NS2 protein antibody (GTX131832)

Hepatitis C Virus NS3 protein antibody (GTX131276)

 

Hepatitis C Virus NS5A protein antibody (GTX131272)

 

其他产品列表 

 

Structural

Core

Product Name Cat. No.
Hepatitis C Virus Core Antigen antibody GTX131265
Hepatitis C Virus Core Antigen antibody [A1/3D1] GTX18700
Hepatitis C Virus Core Antigen antibody [B2] GTX18728
Hepatitis C Virus Core Antigen antibody [1E5] (FITC) GTX22584
Hepatitis C Virus Core Antigen antibody [1E5] (Rhodamine) GTX22585
Hepatitis C Virus Core Antigen antibody [6A1] (FITC) GTX40111
Hepatitis C Virus Core Antigen antibody [1868] GTX40705
Hepatitis C Virus Core Antigen antibody [B317M] GTX41719
Hepatitis C Virus Core Antigen antibody [B306M] GTX41720
Hepatitis C Virus Core Antigen antibody [11-B3] GTX41722
Hepatitis C Virus Core Antigen antibody [B057M] GTX42536
Hepatitis C Virus Core Antigen antibody [B056M] GTX42537
Hepatitis C Virus Core Antigen antibody [B055M] GTX42538
Hepatitis C Virus Core Antigen antibody [H6-29] GTX64113
Hepatitis C Virus Core Antigen antibody [H6-29] (Biotin) GTX64114
Hepatitis C Virus Core Antigen antibody [H6-29] (FITC) GTX64115

 

Envelope

Product Name Cat. No.
Hepatitis C Virus E1 protein antibody [1879] GTX36856
Hepatitis C Virus E2 protein antibody GTX103353
Hepatitis C Virus E2 protein antibody [4F6/2] GTX30856
Hepatitis C Virus E2 protein antibody [6F6/I8] GTX30857
Hepatitis C Virus E2 protein antibody GTX30878
Hepatitis C virus E2 protein antibody [1876] GTX40699
Hepatitis C Virus E2 protein antibody [BDI167] GTX40852

 

Non-structural
NS2

Product Name Cat. No.
Hepatitis C Virus NS2 protein antibody GTX131832

 

NS3

Product Name Cat. No.
Hepatitis C Virus NS3 protein antibody GTX103356
Hepatitis C Virus NS3 protein antibody GTX131269
Hepatitis C Virus NS3 protein antibody GTX131276
Hepatitis C Virus NS3 protein antibody [20-8] GTX18663
Hepatitis C Virus NS3 protein antibody [113] GTX18664
Hepatitis C Virus NS3 protein antibody [281] GTX18665
Hepatitis C Virus NS3 protein antibody [5] GTX18666
Hepatitis C Virus NS3 protein antibody [328] GTX18667
Hepatitis C Virus NS3 protein antibody [251] GTX18668
Hepatitis C Virus NS3 protein antibody [242] GTX18669
Hepatitis C Virus NS3 protein antibody [806] GTX18671
Hepatitis C Virus NS3 protein antibody [70-13] GTX18730
Hepatitis C Virus NS3 protein antibody GTX36540
Hepatitis C Virus NS3 protein antibody GTX41124
Hepatitis C Virus NS3 protein antibody [9-G2] GTX41696
Hepatitis C Virus NS3 protein antibody [BDI371] GTX41717
Hepatitis C Virus NS3 protein antibody [V/1859] GTX78171
Hepatitis C Virus NS3 protein antibody [V/1828] GTX81101

 

NS4

Product Name Cat. No.
Hepatitis C Virus NS4 protein antibody [1G7] (Biotin) GTX22591
Hepatitis C Virus NS4 protein antibody [1G7] (FITC) GTX22592
Hepatitis C Virus NS4 protein antibody [1G7] (Rhodamine) GTX22593
Hepatitis C Virus NS4 protein antibody GTX40955
Hepatitis C Virus NS4A protein antibody [5D4/10E7] GTX19048
Hepatitis C Virus NS4A protein antibody [497] GTX19052
Hepatitis C Virus NS4A protein antibody [4-F5] GTX41689
Hepatitis C Virus NS4A protein antibody [S4-13] GTX64116
Hepatitis C Virus NS4A protein antibody [S4-13] (Biotin) GTX64117
Hepatitis C Virus NS4A protein antibody [S4-13] (FITC) GTX64118
Hepatitis C Virus NS4B protein antibody [2-H1] GTX41684

 

NS5

Product Name Cat. No.
Hepatitis C Virus NS5 protein antibody GTX36547
Hepatitis C virus NS5 protein antibody [BGN/1246/5G7] GTX40671
Hepatitis C Virus NS5 protein antibody [8926] GTX64119
Hepatitis C Virus NS5 protein antibody [8926] (FITC) GTX64120
Hepatitis C Virus NS5 protein antibody [8926] (Biotin) GTX64121
Hepatitis C Virus NS5A protein antibody GTX103358
Hepatitis C Virus NS5A protein antibody GTX131272
Hepatitis C Virus NS5A protein antibody [388] GTX40342
Hepatitis C Virus NS5A protein antibody [7-D4] GTX41681
Hepatitis C Virus NS5B protein antibody [NS5B-6] GTX00713
Hepatitis C Virus NS5B protein antibody [NS5B-6] (Biotin) GTX00846
Hepatitis C Virus NS5B protein antibody [NS5B-6] (FITC) GTX00847
Hepatitis C Virus NS5B protein antibody GTX131273
Hepatitis C Virus NS5B protein antibody GTX131274
Hepatitis C Virus NS5B protein antibody [1825] GTX30873
Hepatitis C Virus NS5B protein antibody [5B-12B7] GTX33940


Others

Product Name Cat. No.
Hepatitis C virus antibody [24-8] GTX18662
Hepatitis C virus antibody GTX40404
Hepatitis C virus antibody GTX70330
Hepatitis C virus antibody GTX70331
Hepatitis C Virus Core + NS3 + NS4 antibody GTX40324