产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 0.5 - 2 μg/mL |
| Assay dependent |
| 2 μg/mL |
| Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
阳性对照
Human Kidney Tissue Lysate(GTX29995)
产品说明
Anti-ACE2 has no cross response to ACE1.
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2.The immunogen is located within amino acids 150 - 200 of ACE2.
纯化方式
Purified by antigen-affinity chromatography
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
angiotensin I converting enzyme 2 , ACEH
细胞定位
Cytoplasm
功能与背景
Angiotensin converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE1 inhibitors such as catopril and lisinopril do not block ACE2 activity. ACE2 is restricted to the testis, heart, kidney and colon. The full length sequence for ACE2 encodes an 805 amino acid protein with predicted mass of 92.46 kDa and a pI of 5.22. No cross reactivity to ACE1.
数据库
研究领域
產品图片
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GTX15349 WB Image
WB analysis of mouse stomach tissue lysate using GTX15349 ACE2 antibody.
Loading: 15 μg per lane
Dilution: 4μg/ml
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GTX15349 ICC/IF Image
ICC/IF analysis of Caco2 cells using GTX15349 ACE2 antibody.
Dilution: 5μg/ml
Green: ACE2
Blue: DAPI
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GTX15349 ICC/IF Image
IHC-P analysis of human kidney tissue using GTX15349 ACE2 antibody.
Working concentration : 2 μg/ml
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GTX15349 WB Image
WB analysis of human kidney lysate using GTX15349 ACE2 antibody.
Working concentration : 2 μg/ml
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GTX15349 IHC-P Image
IHC-P analysis of human kidney tissue using GTX15349 ACE2 antibody.
Working concentration : 2 μg/ml
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GTX15349 WB Image
WB analysis of rat brain tissue lysate using GTX15349 ACE2 antibody.
Loading: 15 μg per lane
Dilution: 4μg/ml
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GTX15349 WB Image
WB analysis of various samples using GTX15349 ACE2 antibody.
Loading: 15 μg per lane
Dilution: 4μg/ml
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