形式
Liquid
存储溶液
PBS, 0.1% BSA
保存剂
0.02% Sodium azide
存放说明
Store the peptide at -20ºC, stable for one year.
浓度
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
Angiotensin I Converting Enzyme 2 , Aceh , Ace2
细胞定位
Nuclear
功能与背景
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
研究领域
