产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 1:500-1:3000 |
| Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
产品说明
This antibody was raised against human ADAM17 Intracellular domain.
预测种属反应
Rat, Chicken, Pig(>80% identity)
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
2 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant protein encompassing a sequence within the Intracellular domain of human ADAM17. The exact sequence is proprietary.
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
ADAM metallopeptidase domain 17 , ADAM18 , CD156B , CSVP , NISBD , NISBD1 , TACE
细胞定位
Membrane; Single-pass type I membrane protein
功能与背景
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
数据库
研究领域
產品图片
![Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047](/templates/default/js/lightbox/images/loading.gif "Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047")
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GTX637047 IHC-P Image
ADAM17 antibody [HL1572] detects ADAM17 protein at cell membrane and cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded cat mammary gland.ADAM17 stained by ADAM17 antibody [HL1572] (GTX637047) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX637047 IHC-P Image
ADAM17 antibody [HL1572] detects ADAM17 protein at cell membrane and cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded dog tissues.ADAM17 stained by ADAM17 antibody [HL1572] (GTX637047) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX637047 WB Image
Whole cell extract (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with ADAM17 antibody [HL1572] (GTX637047) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
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GTX637047 IHC-P Image
ADAM17 antibody [HL1572] detects ADAM17 protein at cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded human breast carcinoma.ADAM17 stained by ADAM17 antibody [HL1572] (GTX637047) diluted at 1:200.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX637047 WB Image
Various whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ADAM17 antibody [HL1572] (GTX637047) diluted at 1:2000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
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![Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047](/upload/website/prouct_img/small/GTX637047/GTX637047_44781_20230203_IHC-P_Cat_23020621_257.webp "Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047](/upload/website/prouct_img/small/GTX637047/GTX637047_44781_20230203_IHC-P_multiple_Dog_23020621_716.webp "Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in Western Blot (WB). GTX637047](/upload/website/prouct_img/small/GTX637047/GTX637047_T-44711_20220708_WB_M_22071401_165.webp "Anti-ADAM17 antibody [HL1572] used in Western Blot (WB). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047](/upload/website/prouct_img/small/GTX637047/GTX637047_T-44711_20220708_IHC-P_22071823_146.webp "Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in Western Blot (WB). GTX637047](/upload/website/prouct_img/small/GTX637047/GTX637047_44781_20220826_WB_22083119_664.webp "Anti-ADAM17 antibody [HL1572] used in Western Blot (WB). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047](/upload/website/prouct_img/normal/GTX637047/GTX637047_44781_20230203_IHC-P_Cat_23020621_257.webp "Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047](/upload/website/prouct_img/normal/GTX637047/GTX637047_44781_20230203_IHC-P_multiple_Dog_23020621_716.webp "Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in Western Blot (WB). GTX637047](/upload/website/prouct_img/normal/GTX637047/GTX637047_T-44711_20220708_WB_M_22071401_165.webp "Anti-ADAM17 antibody [HL1572] used in Western Blot (WB). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047](/upload/website/prouct_img/normal/GTX637047/GTX637047_T-44711_20220708_IHC-P_22071823_146.webp "Anti-ADAM17 antibody [HL1572] used in IHC (Paraffin sections) (IHC-P). GTX637047")
![Anti-ADAM17 antibody [HL1572] used in Western Blot (WB). GTX637047](/upload/website/prouct_img/normal/GTX637047/GTX637047_44781_20220826_WB_22083119_664.webp "Anti-ADAM17 antibody [HL1572] used in Western Blot (WB). GTX637047")
