产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 0.03-0.1μg/ml |
| Assay dependent |
| Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
阳性对照
The peptide used to generate this antibody is available for purchase (GTX88073-PEP).
产品说明
This antibody is expected to recognize both reported isoforms (NP_000681.2; NP_001191818.1).
预测种属反应
Bovine, Dog, Pig(>80% identity)
产品属性
形式
Liquid
存储溶液
TBS, 0.5% BSA
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
0.50 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Peptide with sequence C-DETQFKKILGYIN, from the internal region of the protein sequence according to NP_000681.2; NP_001191818.1.
纯化方式
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
aldehyde dehydrogenase 2 family member , ALDH-E2 , ALDHI , ALDM
细胞定位
Mitochondrion matrix
功能与背景
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
数据库
研究领域
產品图片
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GTX88073 ELISA Image
ELISA analysis of ALDH2 protein using GTX88073 ALDH2 antibody, Internal.
Capture : GTX101429 (2.5μg/ml)
Detection : GTX88073 (1.5μg/ml)
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GTX88073 WB Image
WB analysis of mouse liver lysate using GTX88073 ALDH2 antibody, Internal.
Dilution : 0.03μg/ml
Loading : 35μg protein in RIPA buffer
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