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ATM (phospho Ser1981)抗体 [10H11]

Orthogonal
Anti-ATM (phospho Ser1981) antibody [10H11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15666
Anti-ATM (phospho Ser1981) antibody [10H11] used in Western Blot (WB). GTX15666
Anti-ATM (phospho Ser1981) antibody [10H11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15666
Anti-ATM (phospho Ser1981) antibody [10H11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15666
Anti-ATM (phospho Ser1981) antibody [10H11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15666
Anti-ATM (phospho Ser1981) antibody [10H11] used in Western Blot (WB). GTX15666

目录号 GTX15666

宿主

 Mouse

克隆

 Monoclonal

克隆编号

 10H11

同种型

 IgG1

实验应用

 WB, ICC/IF, IP

种属反应

 Human, Mouse
产品包装
100 μg (¥5000)
查看所有 ATM 的产品

产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认
实验应用 稀释倍数
WB 1:500 - 1:1000
ICC/IF 1:250
IP Assay dependent
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

351 kDa. ( Note )

产品属性

形式

Liquid

存储溶液

PBS, 0.1% BSA

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

Batch dependent (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Synthetic peptide corresponding to residues S(1974) L A F E E S(p) Q S T T I S S(1988) of human ATM Kinase protein.

纯化方式

Protein G purified

偶联

Unconjugated

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

ATM serine/threonine kinase , AT1 , ATA , ATC , ATD , ATDC , ATE , TEL1 , TELO1

细胞定位

Nucleus,Cytoplasmic vesicle

功能与背景

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

数据库

研究领域

產品图片

Anti-ATM (phospho Ser1981) antibody [10H11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15666

GTX15666 ICC/IF Image

Orthogonal

ICC/IF analysis of 293 untreated cells (left panel) or stimulated cells with 100 mJ UV (right panel) using GTX15666 ATM (phospho Ser1981) antibody [10H11].
Fixation : Formalin
Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes

Anti-ATM (phospho Ser1981) antibody [10H11] used in Western Blot (WB). GTX15666

GTX15666 WB Image

Orthogonal

WB analysis of 40 ug of lysate from HeLa cells untreated (Lane 1), treated with 10uM Camptothecin for 4h (Lane 2) or 12h (Lane 3) using GTX15666 ATM (phospho Ser1981) antibody [10H11].
Dilution : 1:1000

Anti-ATM (phospho Ser1981) antibody [10H11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15666

GTX15666 ICC/IF Image

ICC/IF analysis of HT-29 cells using GTX15666 ATM (phospho Ser1981) antibody [10H11].
Left : Primary antibody
Right : Negative control without primary antibody
Fixation : Formalin
Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes
Dilution : 1:50 and incubated overnight

Anti-ATM (phospho Ser1981) antibody [10H11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15666

GTX15666 ICC/IF Image

ICC/IF analysis of HeLa cells irradiated with UV for 4 hours using GTX15666 ATM (phospho Ser1981) antibody [10H11]. Panel e is a no primary antibody control.
Green : Primary antibody
Blue : Nuclei
Red : Actin
Fixation : 4% paraformaldehyde
Permeabilization : 0.1% Trito X-100 for 10 minutes

Anti-ATM (phospho Ser1981) antibody [10H11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15666

GTX15666 ICC/IF Image

Orthogonal

ICC/IF analysis of HeLa cells left untreated (left panels) or treated with 10uM Camptothecin for 4 hours (right panels) using GTX15666 ATM (phospho Ser1981) antibody [10H11].
Green : Primary antibody
Blue : Nuclei
Red : Actin
Fixation : Formalin
Permeabilization : 0.1% Triton X-100 in TBS for 10 minutes

Anti-ATM (phospho Ser1981) antibody [10H11] used in Western Blot (WB). GTX15666

GTX15666 WB Image

WB analysis of gamma-irradiated HeLa cells using GTX15666 ATM (phospho Ser1981) antibody [10H11].

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SDS
PBS.pdf
Sodium Azide.pdf
产品包装 报价 (¥)
¥ 5000
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