产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 1:500-1:3000 |
| 1:100-1:1000 |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Carrier-protein conjugated synthetic peptide surrounding phospho Thr1989 of human ATR. The exact sequence is proprietary.
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1
细胞定位
Nucleus
功能与背景
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
数据库
研究领域
產品图片
![Anti-ATR (phospho Thr1989) antibody [HL1836] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX637561](/templates/default/js/lightbox/images/loading.gif "Anti-ATR (phospho Thr1989) antibody [HL1836] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX637561")
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GTX637561 ICC/IF Image
ATR (phospho Thr1989) antibody [HL1836] detects ATR (phospho Thr1989) protein at cytoplasm and nucleus by immunofluorescent analysis.Sample: Mock and treated HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody [HL1836] (GTX637561) diluted at 1:500.Blue: Fluoroshield with DAPI (GTX30920).
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GTX637561 WB Image
Untreated (–) and treated (+) HeLa whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATR (phospho Thr1989) antibody [HL1836] (GTX637561) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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文献引用
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产品评论
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![Anti-ATR (phospho Thr1989) antibody [HL1836] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX637561](/upload/website/prouct_img/small/GTX637561/GTX637561_T-44823_20221104_ICC_IF_treatment_Etoposide_22112219_863.webp "Anti-ATR (phospho Thr1989) antibody [HL1836] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX637561")
![Anti-ATR (phospho Thr1989) antibody [HL1836] used in Western Blot (WB). GTX637561](/upload/website/prouct_img/small/GTX637561/GTX637561_T-44823_20221118_WB_treatment_etoposide_22112219_690.webp "Anti-ATR (phospho Thr1989) antibody [HL1836] used in Western Blot (WB). GTX637561")
![Anti-ATR (phospho Thr1989) antibody [HL1836] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX637561](/upload/website/prouct_img/normal/GTX637561/GTX637561_T-44823_20221104_ICC_IF_treatment_Etoposide_22112219_863.webp "Anti-ATR (phospho Thr1989) antibody [HL1836] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX637561")
![Anti-ATR (phospho Thr1989) antibody [HL1836] used in Western Blot (WB). GTX637561](/upload/website/prouct_img/normal/GTX637561/GTX637561_T-44823_20221118_WB_treatment_etoposide_22112219_690.webp "Anti-ATR (phospho Thr1989) antibody [HL1836] used in Western Blot (WB). GTX637561")
