ATR (phospho Thr1989)抗体

Name: ATR (phospho Thr1989)抗体
Brand: GeneTex
SKU: GTX128145
Price: 4000.00 RMB
Rating: 5 (1 reviews)

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

Anti-ATR (phospho Thr1989) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX128145

Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145

Anti-ATR (phospho Thr1989) antibody used in Immunoprecipitation (IP). GTX128145

目录号 GTX128145

文献引用 85

宿主	Rabbit
克隆	Polyclonal
同种型	IgG
实验应用	WB, ICC/IF, IHC-P, IP
种属反应	Human, Mouse
产品包装	100 μl (¥4000), 25 μl (¥1700)

查看所有 ATR 的产品

View product citations for antibody GTX128145 on CiteAb

产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认

实验应用	稀释倍数
WB	1:500-1:3000
ICC/IF	1:100-1:1000
IHC-P	1:100-1:1000
IP	1:100-1:500

WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

301 kDa. ( Note )

阳性对照

Raji nuclear extract

产品属性

形式

Liquid

存储溶液

PBS, 1% BSA, 20% Glycerol

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

0.09 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Carrier-protein conjugated synthetic peptide surrounding phospho Thr1989 of human ATR. The exact sequence is proprietary.

纯化方式

Purified by antigen-affinity chromatography.

偶联

Unconjugated

RRID

AB_2687562

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

别名

ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1

细胞定位

Nucleus

功能与背景

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]

数据库

Gene ID: 545 ATR
UniProt: Q13535 ATR

研究领域

產品图片

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in human lung by immunohistochemical analysis.
Sample: Paraffin-embedded human lung.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:250.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in human colon cancer by immunohistochemical analysis.
Sample: Paraffin-embedded human colon cancer.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:250.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR protein at nucleus in human lung cancer by immunohistochemical analysis.
Sample: Paraffin-embedded human lung cancer.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:250.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 ICC/IF Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunofluorescent analysis.
Sample: Mock and treated HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse heart.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:1000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse muscle.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:1000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 WB Image

Raji whole cell and nuclear extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

GTX128145 IP Image

Immunoprecipitation of ATR (phospho Thr1989) protein from HCT-116 whole cell extracts treated with Hydroxyurea for 6 hr using 5 μg of ATR (phospho Thr1989) antibody (GTX128145).
Western blot analysis was performed using ATR (phospho Thr1989) antibody (GTX128145).
EasyBlot anti-Rabbit IgG (GTX221666-01) was used as a secondary reagent.

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human ovarian cancer.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse liver.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 ICC/IF Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Red: phalloidin, a cytoskeleton marker, diluted at 1:100.

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in mouse liver by immunohistochemical analysis.
Sample: Paraffin-embedded mouse liver.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:200.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 WB Image

Untreated (–) and treated (+) HeLa whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

GTX128145 WB Image

Untreated (–) and treated (+) HCT116 whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:2000.

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human esophageal carcinoma.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in human breast carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:250.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX128145 WB Image

The data was published in the journal Breast Cancer Res in 2017.PMID: 29145865

GTX128145 IHC-P Image

The data was published in the journal Inflamm Regen in 2019.PMID: 31057688

GTX128145 WB Image

The data was published in the journal PLoS Genet in 2015.PMID: 26684013

GTX128145 WB Image

The data was published in the journal Nat Commun in 2019.PMID: 31757956

GTX128145 WB Image

The data was published in the 2022 in Sci Rep. PMID: 35361811

GTX128145 WB Image

The data was published in the 2022 in Sci Rep. PMID: 35361811

GTX128145 WB Image

The data was published in the 2022 in Sci Rep. PMID: 35361811

GTX128145 WB Image

The data was published in the 2020 in Nat Commun. PMID: 32796829

GTX128145 WB Image

The data was published in the journal PLoS Pathog in 2017. PMID: 28264028

GTX128145 WB Image

The data was published in the journal PLoS One in 2017. PMID: 28558031

GTX128145 ICC/IF Image

The data was published in the journal Elife in 2019. PMID: 31135337

GTX128145 WB Image

The data was published in the journal Nat Commun in 2018.PMID: 29472538

GTX128145 WB Image

The data was published in the journal Nat Commun in 2018.PMID: 29472538

GTX128145 ICC/IF Image

The data was published in the journal EMBO J in 2018.PMID: 29773570

GTX128145 WB Image

The data was published in the journal Oncotarget in 2017.PMID: 28915641

GTX128145 WB Image

The data was published in the journal Oncotarget in 2017.PMID: 28915641

GTX128145 WB Image

The data was published in the journal Elife in 2019. PMID: 31135337

GTX128145 WB Image

The data was published in the journal Life Sci Alliance in 2018. PMID: 30456359

文献引用

Application Reference

Zhang C et al. EMBO J 2024; 43 (1) : 61-86 YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.

Hardaker EL et al. Nat Commun 2024; 15 (1) : 1700 The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment.

Liu MY et al. Nucleic Acids Res 2024; 52 (1) : 204-222 ATR phosphorylates DHX9 at serine 321 to suppress R-loop accumulation upon genotoxic stress.

Zhou LL et al. Nat Commun 2023; 14 (1) : 7069 Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.

Xin D et al. Adv Sci (Weinh) 2023; 10 (28) : e2206931 Pre-rRNA Facilitates TopBP1-Mediated DNA Double-Strand Break Response.

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产品评论

ATR (phospho Thr1989) antibody 目录号 GTX128145

Rating

( Average 5 based on 1 users reviews)

实验应用

Western Blot(WB)

( Average 5 based on 1 users reviews)

Date : Anonymous submitted on 03-Feb-2016

Score :

Application Tested : WB

Sample Species : Hu

Sample : HT29 cells

Amount used : 20μg

Blocking : 5% milk in PBST, 25°C, 0.5Hr

Primary Antibody : 1:2000, 4°C, 16Hr

我要评论产品

Application Reference

Zhang C et al. EMBO J 2024; 43 (1):61-86 YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.

Hardaker EL et al. Nat Commun 2024; 15 (1):1700 The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment.

Liu MY et al. Nucleic Acids Res 2024; 52 (1):204-222 ATR phosphorylates DHX9 at serine 321 to suppress R-loop accumulation upon genotoxic stress.

Zhou LL et al. Nat Commun 2023; 14 (1):7069 Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.

Ning K et al. Mol Ther Methods Clin Dev 2023; 31:101115 Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium.

Xin D et al. Adv Sci (Weinh) 2023; 10 (28):e2206931 Pre-rRNA Facilitates TopBP1-Mediated DNA Double-Strand Break Response.

Zhou H et al. PLoS Genet 2023; 19 (7):e1010856 UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1.

Tulpule A et al. Res Sq 2023; FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer.

G?der A et al. iScience 2023; 26 (6):106951 PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors.

Garbarino O et al. Aging Cell 2023; 22 (7):e13853 Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis.

Menon S et al. bioRxiv 2023; FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer.

Zhang C et al. Oncogene 2023; 42 (13):967-979 BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance.

实验应用 : WB

种属反应 : Human

Ning K et al. mBio 2023; 14 (1):e0352822 Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication.

Hsiao HW et al. Biomolecules 2023; 13 (1) Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses.

Grange LJ et al. Nat Commun 2022; 13 (1):6664 Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.

Janna Luessing et al. iScience 2022; 25 (7):104536 A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission.

实验应用 : ICC/IF

种属反应 : Human

Tom Egger et al. Sci Rep 2022; 12 (1):5422 A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress.

Maya Raghunandan et al. EMBO J 2021; 40 (6):e106336 NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.

实验应用 : WB

种属反应 : Human

Zhengke Li et al. FASEB J 2021; 35 (5):e21373 ATR prevents Ca²⁺ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling.

实验应用 : WB

种属反应 : Human

Gro Elise R?dland et al. Cancers (Basel) 2021; 13 (15) Differential Effects of Combined ATR/WEE1 Inhibition in Cancer Cells.

实验应用 : WB

种属反应 : Human

Boucher D et al. Sci Rep 2021; 11 (1):20256 hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.

实验应用 : WB

种属反应 : Human

Alghoul E et al. STAR Protoc 2021; 2 (3):100677 An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells.

实验应用 : WB

种属反应 : Human

Hernandez Borrero L et al. Elife 2021; 10 A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53.

实验应用 : WB

种属反应 : Human

Ho K et al. Sci Rep 2021; 11 (1):7502 Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress.

实验应用 : WB

种属反应 : Human

Gaillard S et al. Biol Open 2021; 10 (5) KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.

实验应用 : WB

种属反应 : Human

Takeishi Y et al. J Biol Chem 2020; 295 (4):1056-1065 SMARCAD1-mediated recruitment of the DNA mismatch repair protein MutLα to MutSα on damaged chromatin induces apoptosis in human cells.

Wang R et al. Proc Natl Acad Sci U S A 2020; 117 (52):33436-33445 DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.

实验应用 : WB

种属反应 : Human

Sarker AH et al. Environ Mol Mutagen 2020; 61 (6):635-646 Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells.

Rainey MD et al. Cell Rep 2020; 32 (9):108096 ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.

实验应用 : WB

种属反应 : Human

Lam FC et al. Nat Commun 2020; 11 (1):4083 BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.

实验应用 : WB

种属反应 : Human

Ito SS et al. J Biol Chem 2020; 295 (37):12946-12961 Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways.

实验应用 : WB

种属反应 : Human

Dunlop CR et al. Br J Cancer 2020;

实验应用 : WB

种属反应 : Human

Zheng T et al. Cell Death Differ 2020; (Epub) RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.

实验应用 : WB

种属反应 : Human

Wang S et al. Cancer Lett 2020; 488:40-49 Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer.

实验应用 : WB

种属反应 : Human

Srivastava M et al. EMBO Rep 2020; 21 (6):e49123 HMCES safeguards replication from oxidative stress and ensures error-free repair.

实验应用 : WB

种属反应 : Human

Andersson MK et al. Oncogenesis 2020; 9 (1):5 ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma.

实验应用 : WB

种属反应 : Human

Rikitake M et al. Genes Cells 2020; (Epub) MLH1-mediated recruitment of FAN1 to chromatin for the induction of apoptosis triggered by O⁶ -methylguanine.

实验应用 : WB

种属反应 : Human

Yamamoto M et al. Cancer Res 2019; 79 (8):2031-2041 MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells.

Wang C et al. Oncogene 2019; 38 (14):2451-2463 Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.

Kim W et al. Nat Commun 2019; 10 (1):5304 ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.

实验应用 : WB

种属反应 : Human

Tang M et al. Sci Adv 2019; 5 (3):eaav1118 SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.

Fragkos M et al. Oncotarget 2019; 10 (43):4407-4423 Dicer prevents genome instability in response to replication stress.

实验应用 : WB

种属反应 : Human

Bigot N et al. Elife 2019; 8 Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.

Shaj K et al. Photochem Photobiol 2019; ATR Kinase Activity Limits Mutagenesis and Promotes the Clonogenic Survival of Quiescent Human Keratinocytes Exposed to UVB Radiation.

Hutcherson RJ et al. Mutat Res 2019; 816-818:111678

实验应用 : WB

Hahm ER et al. Mol Carcinog 2019; (Epub)

实验应用 : WB

种属反应 : Human

Matsuno Y et al. Nat Commun 2019; 10 (1):3925 Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro.

实验应用 : WB

种属反应 : Mouse

Combes E et al. Cancer Res 2019; (Epub)

实验应用 : WB

种属反应 : Human

Chen X et al. J Cancer Res Clin Oncol 2019; 145 (6):1471-1484 IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2.

实验应用 : ICC/IF

种属反应 : Human

Watanabe K et al. Inflamm Regen 2019; 39:8 Age-related dysfunction of the DNA damage response in intestinal stem cells.

实验应用 : IHC-P

种属反应 : Mouse

Chou FJ et al. EBioMedicine 2019; 40:504-516 Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression.

实验应用 : WB

种属反应 : Human

Liu H et al. Oncotarget 2018; 9 (4):4318-4337 Sodium fluoride causes hepatocellular S-phase arrest by activating ATM-p53-p21 and ATR-Chk1-Cdc25A pathways in mice.

Kumbhar R et al. Life Sci Alliance 2018; 1 (3):e201800096 Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling.

Jones GN et al. Br J Cancer 2018; 119 (10):1233-1243 pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.

实验应用 : WB

种属反应 : Human

Jin L et al. Cancer Cell 2018; 34 (2):315-330.e7 mast1 drives * resistance in human cancers by rewiring craf-independent mek activation.

Ramhari Kumbhar et al. Life Science Alliance 2018; (Epub) Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling.

实验应用 : WB

种属反应 : Human

Wallez Y et al. Mol Cancer Ther 2018; (Epub) the atr inhibitor azd6738 synergizes with * in vitro and in vivo to induce pancreatic ductal adenocarcinoma regression.

Li Z et al. EMBO J 2018; (Epub) hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability.

实验应用 : WB

种属反应 : Human

Zhang J et al. Oncogene 2018; (Epub) BRD4 facilitates replication stress-induced DNA damage response.

实验应用 : WB

种属反应 : Human

Pons M et al. Arch Toxicol 2018; (Epub) Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells.

实验应用 : WB

种属反应 : Human

Sengupta S et al. Mol Cancer Ther 2018; (Epub) Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors.

实验应用 : WB

种属反应 : Human

Limpose KL et al. Nucleic Acids Res 2018; (Epub) Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.

实验应用 : WB

种属反应 : Human

Goder A et al. Nat Commun 2018; 9 (1):764 HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.

实验应用 : WB

种属反应 : Human

Landsverk H.B. et al. bioRxiv 2018; (Epub) Regulation of ATR activity by the RNA polymerase II phosphatase PNUTS-PP1.

实验应用 : WB, IP

种属反应 : Human

Hu L et al. J Immunol 2018; (Epub) TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC^-/- Mice.

种属反应 : Mouse

Lin YF et al. Nucleic Acids Res 2018; (Epub) PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway.

实验应用 : WB

种属反应 : Human

Beyaert M et al. Oncotarget 2017; 8 (34):56906-56920 Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function.

Ganaie SS et al. PLoS Pathog 2017; 13 (5):e1006370 Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex.

Xu P et al. PLoS Pathog 2017; 13 (3):e1006266 Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway.

Kemp MG et al. J Biol Chem 2017; 292 (30):12424-12435 DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).

实验应用 : WB

种属反应 : Human

Zou W et al. J Virol 2017; (Epub) Human Parvovirus B19 Utilizes Cellular DNA Replication Machinery for Viral DNA Replication.

Hromas R et al. Breast Cancer Res 2017; 19 (1):122 The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells.

实验应用 : WB

种属反应 : Human

Mohr A et al. Cell Death Differ 2017; (Epub) Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment.

实验应用 : WB

种属反应 : Human

Muralidharan SV et al. Cell Death Dis 2017; 8 (8):e2982 BET bromodomain inhibitors synergize with ATR inhibitors in melanoma in melanoma.

实验应用 : WB

种属反应 : Human

Tan SLW et al. Cell 2017; 169 (6):1105-1118.e15 A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.

实验应用 : WB

种属反应 : Human

Iwata T et al. PLoS One 2017; 12 (5):e0178221 The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy.

实验应用 : WB

种属反应 : Human

Singh V et al. Cell Cycle 2017;:43112 Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity.

实验应用 : WB

种属反应 : Human

Ashton NW et al. DNA Repair 2017; (Epub) hSSB1 Phosphorylation Is Dynamically Regulated By DNA-PK and PPP-Family Protein Phosphatases.

实验应用 : WB

种属反应 : Human

Williamson CT et al. Nat Commun 2016; 7:13837 ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.

Kanu N et al. Oncogene 2016; 35 (30):4009-19 RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.

实验应用 : WB

种属反应 : Mouse

Fujikane R et al. Scientific Reports 2016; 6:31714 Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis.

实验应用 : WB

种属反应 : Human

Deng X et al. PLoS Pathog 2016; 12 (1):e1005399 Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways.

实验应用 : WB

种属反应 : Human

Wu Y et al. PLoS Genet 2015; 11 (12):e1005675 EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

Beggs KM et al. Toxicology 2015; 331:35-46 Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.

实验应用 : WB

种属反应 : Human

Glanzer JG et al. Cancer Res 2014; RPA Inhibition increases Replication Stress and Suppresses Tumor Growth.

实验应用 : WB

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产品包装	报价 (¥)
100 μl	¥ 4000
25 μl	¥ 1700
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ATR (phospho Thr1989)抗体

目录号 GTX128145

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克隆

同种型

实验应用

种属反应

产品应用

应用说明

预期分子量

阳性对照

产品属性

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存储溶液

存放说明

浓度

免疫原种属

免疫原

纯化方式

偶联

RRID

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别名

细胞定位

功能与背景

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產品图片

GTX128145 IHC-P Image

GTX128145 IHC-P Image

GTX128145 IHC-P Image

GTX128145 ICC/IF Image

GTX128145 IHC-P Image

GTX128145 IHC-P Image

GTX128145 WB Image

GTX128145 IP Image

GTX128145 IHC-P Image

GTX128145 IHC-P Image

GTX128145 ICC/IF Image

GTX128145 IHC-P Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 IHC-P Image

GTX128145 IHC-P Image

GTX128145 WB Image

GTX128145 IHC-P Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 ICC/IF Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 ICC/IF Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 WB Image

GTX128145 WB Image

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ATR (phospho Thr1989) antibody 目录号 GTX128145

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