产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant fragment of human ATXN2
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
ataxin 2 , ATX2 , SCA2 , TNRC13
细胞定位
Cytoplasm
功能与背景
This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
数据库
研究领域
產品图片
![Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652](/templates/default/js/lightbox/images/loading.gif "Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652")
|
GTX637652 WB Image
Non-transfected (–) and transfected (+) transfected 293T (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATXN2 antibody [HL1903] (GTX637652) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
|
|
|
GTX637652 WB Image
Whole cell extract (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with ATXN2 antibody [HL1903] (GTX637652) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
|
文献引用
目前没有使用 ATXN2 antibody [HL1903] (GTX637652) 的文献被收录。快来回报我们第一篇参考文献吧！
产品评论
目前没有使用 ATXN2 antibody [HL1903] (GTX637652) 的产品评论被收录。快发表第一篇产品评论吧！
![Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652](/upload/website/prouct_img/small/GTX637652/GTX637652_44893_20230217_WB_shRNA_watermark_23022022_679.webp "Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652")
![Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652](/upload/website/prouct_img/small/GTX637652/GTX637652_T-44837_20221209_WB_22121123_552.webp "Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652")
![Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652](/upload/website/prouct_img/normal/GTX637652/GTX637652_44893_20230217_WB_shRNA_watermark_23022022_679.webp "Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652")
![Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652](/upload/website/prouct_img/normal/GTX637652/GTX637652_T-44837_20221209_WB_22121123_552.webp "Anti-ATXN2 antibody [HL1903] used in Western Blot (WB). GTX637652")
