形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
浓度
Batch dependent (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Partially purified human mucin fraction from a pool of cancer tissues of patients with epithelial ovarian cancer.
纯化方式
Purified IgG
偶联
Unconjugated
RRID
AB_384363
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
mucin 16, cell surface associated , CA125
细胞定位
Cell membrane; Single-pass type I membrane protein
功能与背景
This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]
数据库
研究领域
![Anti-CA125 antibody [OV185:1] used in IHC (Paraffin sections) (IHC-P). GTX20697](/upload/website/prouct_img/small/GTX20697/GTX20697_20191203_IHC-P_41_w_23060620_768.webp "Anti-CA125 antibody [OV185:1] used in IHC (Paraffin sections) (IHC-P). GTX20697")
![Anti-CA125 antibody [OV185:1] used in IHC (Paraffin sections) (IHC-P). GTX20697](/upload/website/prouct_img/normal/GTX20697/GTX20697_20191203_IHC-P_41_w_23060620_768.webp "Anti-CA125 antibody [OV185:1] used in IHC (Paraffin sections) (IHC-P). GTX20697")
