产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| Assay dependent |
| Assay dependent |
| Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant fragmemt of human CBP
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
CREB binding protein , CBP , KAT3A , MKHK1 , RSTS , RSTS1
细胞定位
Cytoplasm,Nucleus
功能与背景
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
数据库
研究领域
產品图片
![Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201](/templates/default/js/lightbox/images/loading.gif "Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201")
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GTX638201 WB Image
Wild-type (WT) and CREBBP knockout (KO) HeLa cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with CBP antibody [HL2197] (GTX638201) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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GTX638201 WB Image
Whole cell extract (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with CBP antibody [HL2197] (GTX638201) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
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GTX638201 IHC-P Image
CBP antibody [HL2197] detects CBP protein by immunohistochemical analysis.Sample: Paraffin-embedded mouse tissues.CBP stained by CBP antibody [HL2197] (GTX638201) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX638201 IHC-P Image
CBP antibody [HL2197] detects CBP protein by immunohistochemical analysis.Sample: Paraffin-embedded rat tissues.CBP stained by CBP antibody [HL2197] (GTX638201) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX638201 ICC/IF Image
CBP antibody [HL2197] detects CBP protein at nucleus by immunofluorescent analysis.Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: CBP stained by CBP antibody [HL2197] (GTX638201) diluted at 1:500.Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:1000.
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GTX638201 WB Image
Various whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with CBP antibody [HL2197] (GTX638201) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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文献引用
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产品评论
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![Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201](/upload/website/prouct_img/small/GTX638201/GTX638201_45012_20230707_WB_KO_watermark_23071223_932.webp "Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201")
![Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201](/upload/website/prouct_img/small/GTX638201/GTX638201_T-44942_20230210_WB_M_23021401_925.webp "Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201")
![Anti-CBP antibody [HL2197] used in IHC (Paraffin sections) (IHC-P). GTX638201](/upload/website/prouct_img/small/GTX638201/GTX638201_T-44942_20230303_IHC-P_multiple_M_23031402_444.webp "Anti-CBP antibody [HL2197] used in IHC (Paraffin sections) (IHC-P). GTX638201")
![Anti-CBP antibody [HL2197] used in IHC (Paraffin sections) (IHC-P). GTX638201](/upload/website/prouct_img/small/GTX638201/GTX638201_T-44942_20230303_IHC-P_multiple_R_23031402_367.webp "Anti-CBP antibody [HL2197] used in IHC (Paraffin sections) (IHC-P). GTX638201")
![Anti-CBP antibody [HL2197] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX638201](/upload/website/prouct_img/small/GTX638201/GTX638201_T-44942_20230331_ICC_IF_23041023_716.webp "Anti-CBP antibody [HL2197] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX638201")
![Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201](/upload/website/prouct_img/small/GTX638201/GTX638201_T-44942_20240419_WB_24042400_471.webp "Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201")
![Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201](/upload/website/prouct_img/normal/GTX638201/GTX638201_45012_20230707_WB_KO_watermark_23071223_932.webp "Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201")
![Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201](/upload/website/prouct_img/normal/GTX638201/GTX638201_T-44942_20230210_WB_M_23021401_925.webp "Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201")
![Anti-CBP antibody [HL2197] used in IHC (Paraffin sections) (IHC-P). GTX638201](/upload/website/prouct_img/normal/GTX638201/GTX638201_T-44942_20230303_IHC-P_multiple_M_23031402_444.webp "Anti-CBP antibody [HL2197] used in IHC (Paraffin sections) (IHC-P). GTX638201")
![Anti-CBP antibody [HL2197] used in IHC (Paraffin sections) (IHC-P). GTX638201](/upload/website/prouct_img/normal/GTX638201/GTX638201_T-44942_20230303_IHC-P_multiple_R_23031402_367.webp "Anti-CBP antibody [HL2197] used in IHC (Paraffin sections) (IHC-P). GTX638201")
![Anti-CBP antibody [HL2197] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX638201](/upload/website/prouct_img/normal/GTX638201/GTX638201_T-44942_20230331_ICC_IF_23041023_716.webp "Anti-CBP antibody [HL2197] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX638201")
![Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201](/upload/website/prouct_img/normal/GTX638201/GTX638201_T-44942_20240419_WB_24042400_471.webp "Anti-CBP antibody [HL2197] used in Western Blot (WB). GTX638201")
