摘要
The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.
形式
Liquid
存储溶液
10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
浓度
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Human CD152-IgG heavy chain fusion protein
纯化方式
Purified by affinity chromatography
From tissue culture supernatant
偶联
Phycoerythrin (PE)
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
cytotoxic T-lymphocyte associated protein 4 , ALPS5 , CD , CD152 , CELIAC3 , CTLA-4 , GRD4 , GSE , IDDM12
细胞定位
Cell membrane
功能与背景
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
数据库
研究领域
![Anti-CTLA4 antibody [BNI3] (PE) used in Flow cytometry (FACS). GTX00492-08](/upload/website/prouct_img/small/GTX00492-08/GTX00492-08_20201020_FACS_62_w_23053121_982.webp "Anti-CTLA4 antibody [BNI3] (PE) used in Flow cytometry (FACS). GTX00492-08")
![Anti-CTLA4 antibody [BNI3] (PE) used in Flow cytometry (FACS). GTX00492-08](/upload/website/prouct_img/normal/GTX00492-08/GTX00492-08_20201020_FACS_62_w_23053121_982.webp "Anti-CTLA4 antibody [BNI3] (PE) used in Flow cytometry (FACS). GTX00492-08")
