产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
阳性对照
HepG2
预测种属反应
Mouse, Rat, Bovine, Pig, Chimpanzee(>80% identity)
产品属性
形式
Liquid
存储溶液
0.1M Tris, 0.1M Glycine, 10% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
0.86 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant protein encompassing a sequence within the center region of human ERCC1. The exact sequence is proprietary.
纯化方式
Purified by antigen-affinity chromatography.
偶联
Unconjugated
RRID
AB_1950217
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
ERCC excision repair 1, endonuclease non-catalytic subunit , COFS4 , RAD10 , UV20
细胞定位
Nucleus
功能与背景
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq]
数据库
研究领域
產品图片
![Anti-ERCC1 antibody [N1C3-2] used in Western Blot (WB). GTX112848](/templates/default/js/lightbox/images/loading.gif "Anti-ERCC1 antibody [N1C3-2] used in Western Blot (WB). GTX112848")
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GTX112848 WB Image
Sample (30 ug of whole cell lysate)
A: Hep G2 (GTX27900)
12% SDS PAGE
GTX112848 diluted at 1:1000
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文献引用
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产品评论
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![Anti-ERCC1 antibody [N1C3-2] used in Western Blot (WB). GTX112848](/upload/website/prouct_img/small/GTX112848/GTX112848_WB_w_23060500_808.webp "Anti-ERCC1 antibody [N1C3-2] used in Western Blot (WB). GTX112848")
![Anti-ERCC1 antibody [N1C3-2] used in Western Blot (WB). GTX112848](/upload/website/prouct_img/normal/GTX112848/GTX112848_WB_w_23060500_808.webp "Anti-ERCC1 antibody [N1C3-2] used in Western Blot (WB). GTX112848")
