形式
Liquid
存储溶液
PBS, 0.1% BSA
保存剂
0.02% Sodium azide
存放说明
Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
浓度
200 μg/ml (Please refer to the vial label for the specific concentration.)
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。
别名
Estrogen Receptor 1 , Er , Esr , Esra , Estrr , Era , Nr3A1 , Esr1
功能与背景
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
研究领域