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Filaggrin抗体 [FLG01]

Orthogonal
Anti-Filaggrin antibody [FLG01] used in Western Blot (WB). GTX23137
Anti-Filaggrin antibody [FLG01] used in IHC (Frozen sections) (IHC-Fr). GTX23137
Anti-Filaggrin antibody [FLG01] used in IHC (Frozen sections) (IHC-Fr). GTX23137
Anti-Filaggrin antibody [FLG01] used in Western Blot (WB). GTX23137
Anti-Filaggrin antibody [FLG01] used in (). GTX23137
Anti-Filaggrin antibody [FLG01] used in (). GTX23137
Anti-Filaggrin antibody [FLG01] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX23137

目录号 GTX23137

文献引用 5

宿主

 Mouse

克隆

 Monoclonal

克隆编号

 FLG01

同种型

 IgG1

实验应用

 WB, ICC/IF, IHC-P, IHC-Fr

种属反应

 Human, Mouse
产品包装
500 μl (¥5000)
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产品应用

应用说明

Immunohistochemistry (formalin fixed paraffin embedded): use at a concentration of 2 - 4μg / ml for 30 min at RT. Optimal dilutions / concentrations should be determined by the end user. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.

预期分子量

435 kDa. ( Note )

阳性对照

Skin

产品属性

形式

Liquid

存储溶液

10mM PBS, 0.2% BSA

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

浓度

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Recombinant full length protein

纯化方式

Protein G purified

偶联

Unconjugated

RRID

AB_384952

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

filaggrin , ATOD2

功能与背景

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

数据库

研究领域

產品图片

Anti-Filaggrin antibody [FLG01] used in Western Blot (WB). GTX23137

GTX23137 WB Image

Orthogonal

The data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303

Anti-Filaggrin antibody [FLG01] used in IHC (Frozen sections) (IHC-Fr). GTX23137

GTX23137 IHC-Fr Image

Orthogonal

The data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303

Anti-Filaggrin antibody [FLG01] used in IHC (Frozen sections) (IHC-Fr). GTX23137

GTX23137 IHC-Fr Image

Orthogonal

The data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303

Anti-Filaggrin antibody [FLG01] used in Western Blot (WB). GTX23137

GTX23137 WB Image

Orthogonal

The data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303

Anti-Filaggrin antibody [FLG01] used in (). GTX23137

GTX23137 Image

Orthogonal

The data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303

Anti-Filaggrin antibody [FLG01] used in (). GTX23137

GTX23137 Image

Orthogonal

The data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303

Anti-Filaggrin antibody [FLG01] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX23137

GTX23137 ICC/IF Image

The data was published in the journal Cell Death Dis in 2018. PMID: 29545605

文献引用

Application Reference

Oh JS et al. Nutrients 2021; 13 (9) Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice.
实验应用 : WB
种属反应 : Mouse
Gutowska-Owsiak D et al. Cell Death Dis 2018; 9 (4) : 412 Orchestrated control of filaggrin-actin scaffolds underpins cornification.
实验应用 : ICC/IF
种属反应 : Human
Naeem AS et al. J Allergy Clin Immunol 2017; 139 (4) : 1228-1241 A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis.
Kolesnik M et al. Acta Derm Venereol 2017; : Epub ahead of print Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization.
实验应用 : IHC-P
种属反应 : Human
Biedermann T et al. J Invest Dermatol 2010; 130 (8) : 1996-2009 Human eccrine sweat gland cells can reconstitute a stratified epidermis.
实验应用 : ICC/IF
种属反应 : Human
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PBS.pdf
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产品包装 报价 (¥)
¥ 5000
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