产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预测种属反应
Mouse, Rat, Rabbit, Bovine, Dog, Pig, Chimpanzee, Rhesus Monkey(>80% identity)
产品属性
形式
Liquid
存储溶液
PBS, 2% BSA
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
batch dependent
免疫原种属
Human
免疫原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GPX2. The exact sequence is proprietary.
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
glutathione peroxidase 2 ,GI-GPx ,GPRP ,GPRP-2 ,GPx-2 ,GPx-GI ,GSHPX-GI ,GSHPx-2
细胞定位
Cytoplasm
功能与背景
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
数据库
研究领域
產品图片
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/templates/default/js/lightbox/images/loading.gif "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
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GTX639924 IHC-P Image
IHC-P analysis of human colon descendens mucosa tissue using GTX639924 GPX2 antibody [HMV301] HistoMAX™.
Strong predominantly cytoplasmic GPX2 staining of epithelial cells - predominantly in the crypts. A luminal membrane staining can also be seen.
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GTX639924 IHC-P Image
IHC-P analysis of human bronchus glands tissue using GTX639924 GPX2 antibody [HMV301] HistoMAX™.
In some cases, all cells of the respiratory epithelium show intense nuclear and cytoplasmic GPX2 staining.
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GTX639924 IHC-P Image
IHC-P analysis of human stomach antrum tissue using GTX639924 GPX2 antibody [HMV301] HistoMAX™.
Strong GPX2 staining of the surface epithelium with strongest staining in the most superficial cells. Parietal cells do also show significant staining.
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文献引用
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产品评论
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![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/small/GTX639924/GTX639924_20240403_IHC-P_2_24040301_403.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/small/GTX639924/GTX639924_20240403_IHC-P_1_24040301_822.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/small/GTX639924/GTX639924_20240403_IHC-P_24040301_103.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/normal/GTX639924/GTX639924_20240403_IHC-P_2_24040301_403.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/normal/GTX639924/GTX639924_20240403_IHC-P_1_24040301_822.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
![Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924](/upload/website/prouct_img/normal/GTX639924/GTX639924_20240403_IHC-P_24040301_103.webp "Anti-GPX2 antibody [HMV301] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639924")
