产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预测种属反应
Mouse, Rat, Rabbit, Sheep, Bovine, Cat, Dog, Guinea pig, Pig(>80% identity)
产品属性
形式
Liquid
存储溶液
PBS, 2% BSA
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
batch dependent
免疫原种属
Human
免疫原
Recombinant protein encompassing a sequence within the center region of human Glucocorticoid Receptor. The exact sequence is proprietary.
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
nuclear receptor subfamily 3 group C member 1 ,GCCR ,GCR ,GCRST ,GR ,GRL
细胞定位
Nucleus,Mitochondrion,Cytoplasm
功能与背景
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
数据库
研究领域
產品图片
![Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927](/templates/default/js/lightbox/images/loading.gif "Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927")
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GTX639927 IHC-P Image
IHC-P analysis of human fallopian tube mucosa tissue using GTX639927 Glucocorticoid Receptor antibody [HMV304] HistoMAX™.
Strong GR positivity of all epithelial cells.
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GTX639927 IHC-P Image
IHC-P analysis of human breast tissue using GTX639927 Glucocorticoid Receptor antibody [HMV304] HistoMAX™.
Moderate to strong GR positivity of myoepithelial and luminal cells.
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GTX639927 IHC-P Image
IHC-P analysis of human adrenal gland tissue using GTX639927 Glucocorticoid Receptor antibody [HMV304] HistoMAX™.
Moderate to strong GR positivity of medullary cells while adrenocortical cells are largely GR negative.
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文献引用
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产品评论
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![Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927](/upload/website/prouct_img/small/GTX639927/GTX639927_20240403_IHC-P_24040301_342.webp "Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927")
![Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927](/upload/website/prouct_img/small/GTX639927/GTX639927_20240403_IHC-P_1_24040301_466.webp "Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927")
![Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927](/upload/website/prouct_img/small/GTX639927/GTX639927_20240403_IHC-P_2_24040301_437.webp "Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927")
![Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927](/upload/website/prouct_img/normal/GTX639927/GTX639927_20240403_IHC-P_24040301_342.webp "Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927")
![Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927](/upload/website/prouct_img/normal/GTX639927/GTX639927_20240403_IHC-P_1_24040301_466.webp "Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927")
![Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927](/upload/website/prouct_img/normal/GTX639927/GTX639927_20240403_IHC-P_2_24040301_437.webp "Anti-Glucocorticoid Receptor antibody [HMV304] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639927")
