产品说明
摘要
APOE belongs to the apolipoprotein family and is a 299 a.a. protein with three allelic variants that give rise to the APOE 2, APOE 3, and APOE 4 isoforms. APOE is directly involved in lipoprotein metabolism and functions as a ligand for multiple receptors (e.g., the LDL receptor). These isoforms are critical for brain homeostasis and, while APOE 2 was shown to be protective in terms of Alzheimer’s disease (AD) risk, the 34.4 kDa APOE 4 isoform is a major risk factor for late-onset AD.
产品应用
产品属性
形式
Lyophilized powder
存储溶液
Reconstitute with distilled water to 0.1 mg/ml. Lyophilized from 50mM PBS, 100mM NaCl, 5% Trehalose.
保存剂
No Preservative
存放说明
Store at 4ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. For long-term storage after reconstitution, aliquot and store at -70ºC or below. Do not vortex.
Region/Sequence
Full-length human ApoE4 protein (NP_000032.1)
表达系统
E. Coli
纯度
> 90%
内毒素
< 0.1 EU/μg
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
apolipoprotein E , AD2 , APO-E , ApoE4 , LDLCQ5 , LPG
细胞定位
Secreted,Secreted, extracellular space, extracellular matrix
功能与背景
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
数据库
研究领域
產品图片
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GTX136908-pro Image
1μg of GTX136908-pro Human ApoE4 protein was analyzed using SDS-PAGE and stained with coomassie blue and captured by monochrome camera.
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文献引用
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产品评论
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