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Human LAG3 蛋白, human IgG1 Fc tag (active)

Human LAG3 protein, human IgG1 Fc tag (active). GTX65640-pro
Human LAG3 protein, human IgG1 Fc tag (active). GTX65640-pro

目录号 GTX65640-pro

实验应用

Functional Assay

Speciess

Human
产品包装
50 μg (¥6200)

产品应用

应用说明

Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells.

产品说明

Binds to human, mouse and monkey MHC class II.

产品属性

形式

Liquid

存储溶液

PBS

保存剂

No preservative

存放说明

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

浓度

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Region/Sequence

Thecoding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.

表达系统

CHO cells

纯度

??99% by SDS-PAGE.

内毒素

< 0.001 EU/μg

偶联

Unconjugated

注意事项

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

相关讯息

别名

lymphocyte activating 3 , CD223

数据库

  • Gene ID: 3902 LAG3

研究领域

產品图片

Human LAG3 protein, human IgG1 Fc tag (active). GTX65640-pro

GTX65640-pro Image

LAG3 human Fc fusion protein (GTX65640-pro) induced dendritic cells (DC) maturation. Method: Immature DCs derived from human monocytes, resuspended at 1x106 cells/ml in complete culture medium, are incubated with LAG3 human Fc fusion protein (GTX65640)(10μg/ml), LPS (positive control, 5μg/ml) or human IgG1 (isotype-matched negative control, 10μg/ml) for 48 hours. DC maturation induced by LAG3 human Fc fusion protein or LPS is assessed by the increased expression of MHC Class II, CD80, CD83, CD86 and CD40.

Human LAG3 protein, human IgG1 Fc tag (active). GTX65640-pro

GTX65640-pro Image

Binding of LAG3 human Fc fusion protein (GTX65640-pro) on dendritic and B cells. Method: Monocyte-derived immature DC (iDC), DC matured for 48h with LPS (mDC) and EBV-transformed B-cells are incubated with either an anti-MHC class II MAb (10μg/ml) or GTX65640 LAG3 human Fc fusion protein (10μg/ml) for 30 min. at 4ºC in PBS/1% BSA. The cells are then stained for 30 min. at 4ºC with anti-human Fc antibody.

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SDS
PBS.pdf
产品包装 报价 (¥)
¥ 6200
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