产品说明
摘要
Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
产品应用
应用说明
Shows the biological function of the PD-L1 moiety and exerts a prolonged circulating half- life caused by the modified Fc domain.
产品属性
形式
Lyophilized powder
存储溶液
Reconstitute with 0.2μm-filtered PBS to 100 μg/ml. Lyophilized from 0.2μm-filtered PBS.
保存剂
No preservative
存放说明
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.
Region/Sequence
The extracellular domain of human CD274 [B7-H1] (a.a. 19-238) is fused to the N-terminus of the Fc region of a mutant human IgG1.
表达系统
CHO cells
纯度
??98% by SDS-PAGE.
内毒素
< 0.06 EU/μg
偶联
Unconjugated
注意事项
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
相关讯息
别名
CD274 molecule , B7-H , B7H1 , PD-L1 , PDCD1L1 , PDCD1LG1 , PDL1
数据库
研究领域
文献引用
目前没有使用 Human PD-L1 protein, mutant human IgG1 Fc tag (active) (GTX65754-pro) 的文献被收录。快来回报我们第一篇参考文献吧！
产品评论
目前没有使用 Human PD-L1 protein, mutant human IgG1 Fc tag (active) (GTX65754-pro) 的产品评论被收录。快发表第一篇产品评论吧！
