产品应用
应用说明
Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
*For best results, sonicate immediately prior to use.
产品属性
形式
Liquid
存储溶液
10mM HEPES pH7.4, 100mM NaCl
保存剂
No preservative
存放说明
Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
浓度
Batch dependent (Please refer to the vial label for the specific concentration.)
Region/Sequence
Partial Tau without tagged; SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVLGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE
表达系统
E. coli
纯化方式
Purified by ion-exchange chromatography
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
microtubule associated protein tau , microtubule associated protein tau , DDPAC , FTDP-17 , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU
数据库
研究领域
產品图片
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GTX17675-pro Image
Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau preformed fibrils (GTX17675-pro). Tau preformed fibrils (GTX17675-pro) seed the formation of new tau fibrils when combined with tau monomers (GTX17672-pro). Thioflavin T ex = 450 nm, em = 485 nm.
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GTX17675-pro Image
SDS-PAGE of ~15 kDa Human Tau (K18) protein, mutant P301L (preformed fibrils (PFFs)) (GTX17675-pro).
Lane 1: MW Ladder. Lane 2: Human Tau (K18) protein, mutant P301L (fibrils) (GTX17675-pro).
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文献引用
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产品评论
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