产品应用
应用说明
Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when tau PFFs are combined with tau monomers.
产品属性
形式
Liquid
存储溶液
10mM HEPES pH7.4, 100mM NaCl
保存剂
No preservative
存放说明
Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
浓度
Batch dependent (Please refer to the vial label for the specific concentration.)
Region/Sequence
Full-length without tagged; MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
表达系统
E. coli
纯化方式
Purified by ion-exchange chromatography
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
microtubule associated protein tau , microtubule associated protein tau , DDPAC , FTDP-17 , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU
数据库
研究领域
產品图片
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GTX17672-pro Image
Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau monomers (GTX17672-pro). A greater increase in fluorescence is seen when 50 uM monomer (GTX17672-pro) is combined with 10 nM PFFs (GTX17674-pro or GTX17675-pro), as the fibrils seed the formation of new fibrils from the pool of monomers. Thioflavin T ex = 450 nm, em = 485 nm.
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GTX17672-pro Image
SDS-PAGE of ~67 kDa Human Tau441 (2N4R) protein, mutant P301S (monomer) (GTX17672-pro).
Lane 1: MW ladder. Lane 2: Human Tau441 (2N4R) protein, mutant P301S (monomer) (GTX17672-pro).
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文献引用
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产品评论
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