形式
Lyophilized powder
存储溶液
Reconstitute with ddH₂O to 0.1-0.2 mg/mL. Do not vortex. Lyophilized from 20mM Tris (pH8.0), 150mM NaCl, 0.01% SKL, 5% Trehalose.
保存剂
No preservatives
存放说明
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Region/Sequence
N-terminal His tagged full length human p53 protein (Met1~Asp393, Uniprot #P04637-1)
表达系统
E. coli
纯度
>90%
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53
细胞定位
Cytoplasm , Nucleus , Endoplasmic reticulum , Mitochondrion matrix
功能与背景
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
数据库
研究领域
