产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 1:500-1:3000 |
| Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant fragment of human Insulin Receptor beta
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
insulin receptor , CD220 , HHF5
细胞定位
Cell membrane; Single-pass type I membrane protein
功能与背景
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
数据库
研究领域
產品图片
![Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566](/templates/default/js/lightbox/images/loading.gif "Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566")
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GTX639566 WB Image
Various tissue extracts (50 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with Insulin Receptor Beta antibody [HL2737] (GTX639566) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident femto Western HRP Substrate.
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GTX639566 IHC-P Image
Insulin Receptor beta antibody [HL2737] detects Insulin Receptor beta protein at cell membrane and cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded human pancreatic cancer.Insulin Receptor beta stained by Insulin Receptor beta antibody [HL2737] (GTX639566) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX639566 WB Image
Various whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with Insulin Receptor Beta antibody [HL2737] (GTX639566) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
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文献引用
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产品评论
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![Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566](/upload/website/prouct_img/small/GTX639566/GTX639566_T-45271_20240112_WB_M_tissue_24011618_769.webp "Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566")
![Anti-Insulin Receptor beta antibody [HL2737] used in IHC (Paraffin sections) (IHC-P). GTX639566](/upload/website/prouct_img/small/GTX639566/GTX639566_T-45271_20240111_IHC-P_24012217_456.webp "Anti-Insulin Receptor beta antibody [HL2737] used in IHC (Paraffin sections) (IHC-P). GTX639566")
![Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566](/upload/website/prouct_img/small/GTX639566/GTX639566_45355_20240322_WB_TPM_watermark_24032600_798.webp "Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566")
![Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566](/upload/website/prouct_img/normal/GTX639566/GTX639566_T-45271_20240112_WB_M_tissue_24011618_769.webp "Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566")
![Anti-Insulin Receptor beta antibody [HL2737] used in IHC (Paraffin sections) (IHC-P). GTX639566](/upload/website/prouct_img/normal/GTX639566/GTX639566_T-45271_20240111_IHC-P_24012217_456.webp "Anti-Insulin Receptor beta antibody [HL2737] used in IHC (Paraffin sections) (IHC-P). GTX639566")
![Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566](/upload/website/prouct_img/normal/GTX639566/GTX639566_45355_20240322_WB_TPM_watermark_24032600_798.webp "Anti-Insulin Receptor beta antibody [HL2737] used in Western Blot (WB). GTX639566")
