形式
Liquid
存储溶液
Ascites
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
免疫原种属
Human
免疫原
Purified recombinant fragment of human LMNA expressed in E. Coli.
纯化方式
Unpurified
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
lamin A/C , CDCD1 , CDDC , CMD1A , CMT2B1 , EMD2 , FPL , FPLD , FPLD2 , HGPS , IDC , LDP1 , LFP , LGMD1B , LMN1 , LMNC , LMNL1 , MADA , PRO1
细胞定位
Nucleus,nucleoplasm
功能与背景
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
数据库
研究领域
![Anti-Lamin A antibody [4E7] used in IHC (Paraffin sections) (IHC-P). GTX60478](/upload/website/prouct_img/small/GTX60478/GTX60478_20170912_IHC-P_w_23061123_665.webp "Anti-Lamin A antibody [4E7] used in IHC (Paraffin sections) (IHC-P). GTX60478")
![Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478](/upload/website/prouct_img/small/GTX60478/GTX60478_20170912_WB_1_w_23061123_900.webp "Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478")
![Anti-Lamin A antibody [4E7] used in ELISA (ELISA). GTX60478](/upload/website/prouct_img/small/GTX60478/GTX60478_20170912_ELISA_w_23061123_126.webp "Anti-Lamin A antibody [4E7] used in ELISA (ELISA). GTX60478")
![Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478](/upload/website/prouct_img/small/GTX60478/GTX60478_20170912_WB_w_23061123_524.webp "Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478")
![Anti-Lamin A antibody [4E7] used in IHC (Paraffin sections) (IHC-P). GTX60478](/upload/website/prouct_img/normal/GTX60478/GTX60478_20170912_IHC-P_w_23061123_665.webp "Anti-Lamin A antibody [4E7] used in IHC (Paraffin sections) (IHC-P). GTX60478")
![Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478](/upload/website/prouct_img/normal/GTX60478/GTX60478_20170912_WB_1_w_23061123_900.webp "Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478")
![Anti-Lamin A antibody [4E7] used in ELISA (ELISA). GTX60478](/upload/website/prouct_img/normal/GTX60478/GTX60478_20170912_ELISA_w_23061123_126.webp "Anti-Lamin A antibody [4E7] used in ELISA (ELISA). GTX60478")
![Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478](/upload/website/prouct_img/normal/GTX60478/GTX60478_20170912_WB_w_23061123_524.webp "Anti-Lamin A antibody [4E7] used in Western Blot (WB). GTX60478")
