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Loricrin抗体 [N1], N-term

Orthogonal
Anti-Loricrin antibody [N1], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX116013
Anti-Loricrin antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116013
Anti-Loricrin antibody [N1], N-term used in Western Blot (WB). GTX116013
Anti-Loricrin antibody [N1], N-term used in Western Blot (WB). GTX116013

目录号 GTX116013

文献引用 10

宿主

 Rabbit

克隆

 Polyclonal

同种型

 IgG

实验应用

 WB, ICC/IF, IHC-P

种属反应

 Human
产品包装
100 μl (¥4000),
25 μl (¥1700)
查看所有 Loricrin 的产品

产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认
实验应用 稀释倍数
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

26 kDa. ( Note )

阳性对照

HeLa

预测种属反应

Mouse, Bovine, Rhesus Monkey(>80% identity)

产品属性

形式

Liquid

存储溶液

PBS, 1% BSA, 20% Glycerol

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

0.24 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Loricrin. The exact sequence is proprietary.

纯化方式

Purified by antigen-affinity chromatography.

偶联

Unconjugated

RRID

AB_2037360

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

loricrin

细胞定位

Cytoplasm , Nucleus , nucleoplasm

功能与背景

This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq]

数据库

研究领域

產品图片

Anti-Loricrin antibody [N1], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX116013

GTX116013 ICC/IF Image

Immunofluorescence analysis of methanol-fixed Hep3B, using Loricrin(GTX116013) antibody at 1:500 dilution.

Anti-Loricrin antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116013

GTX116013 IHC-P Image

Loricrin antibody [N1], N-term detects LOR protein at cytosol on HBL438 xenograft by immunohistochemical analysis.
Sample: Paraffin-embedded HBL438 xenograft.
Loricrin antibody [N1], N-term (GTX116013) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Loricrin antibody [N1], N-term used in Western Blot (WB). GTX116013

GTX116013 WB Image

Whole cell extract (30 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with Loricrin antibody [N1], N-term (GTX116013) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Loricrin antibody [N1], N-term used in Western Blot (WB). GTX116013

GTX116013 WB Image

Orthogonal

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Loricrin antibody [N1], N-term (GTX116013) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
The observed expression level is based on the publication: PMID: 12366693

文献引用

Application Reference

Oh JS et al. Nutrients 2021; 13 (9) Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice.
实验应用 : WB
Roy RR et al. Eur J Oral Sci 2021; 129 (1) : e12760 Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium.
实验应用 : IHC-P
Kim SH et al. Nutrients 2020; 12 (1) Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice Through Modulating Immune Balance and Skin Barrier Function.
实验应用 : WB
Wang C et al. Exp Dermatol 2019; (Epub) MiR-744-3p regulates keratinocyte proliferation and differentiation via targeting KLLN in psoriasis.
实验应用 : WB
种属反应 : Human
Wang S et al. Med Sci (Paris) 2018; 34 Focus issue F1 : 94-98 Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes.
实验应用 : WB
种属反应 : Human
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Application Reference
Oh JS et al. Nutrients 2021; 13 (9) Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice.
实验应用 : WB
Roy RR et al. Eur J Oral Sci 2021; 129 (1):e12760 Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium.
实验应用 : IHC-P
Kim SH et al. Nutrients 2020; 12 (1) Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice Through Modulating Immune Balance and Skin Barrier Function.
实验应用 : WB
Wang C et al. Exp Dermatol 2019; (Epub) MiR-744-3p regulates keratinocyte proliferation and differentiation via targeting KLLN in psoriasis.
实验应用 : WB
种属反应 : Human
Wang S et al. Med Sci (Paris) 2018; 34 Focus issue F1:94-98 Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes.
实验应用 : WB
种属反应 : Human
Shimada K et al. J Int Med Res 2018;:3.00E+14 Ectopic transglutaminase 1 and 3 expression accelerating keratinization in oral lichen planus.
实验应用 : IHC-P
种属反应 : Human
Wang T et al. SpringerLink 2018; (Epub) The Role of miR-205 During Skin Wound Reepithelialization.
实验应用 : IHC-P
Qian L et al. Cytokine 2017; 96:114-122 LncRNA expression profile of ΔNp63α in cervical squamous cancers and its suppressive effects on LIF expression.
Wang T et al. Biochim Biophys Acta 2016; 1862 (8):1443-1452 Downregulation of miR-205 in migrating epithelial tongue facilitates skin wound re-epithelialization by derepressing ITGA5.
Dang NN et al. Braz J Med Biol Res 2015; 48 (1):39-45 Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response.
SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
产品包装 报价 (¥)
¥ 4000
¥ 1700
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