产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 1:500-1:3000 |
| Assay dependent |
| 1:100-1:1000 |
| Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
产品说明
This antibody was raised against human MC1 Receptor Intracellular domain.
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Synthetic peptide encompassing a sequence within the Intracellular domain of human MC1 Receptor. The exact sequence is proprietary.
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
melanocortin 1 receptor , CMM5 , MSH-R , SHEP2
细胞定位
Cell membrane; Multi-pass membrane protein
功能与背景
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
数据库
研究领域
產品图片
![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/templates/default/js/lightbox/images/loading.gif "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
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GTX636945 WB Image
Non-transfected (–) and transfected (+) A375 whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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GTX636945 ICC/IF Image
MC1 Receptor antibody [HL1471] detects MC1 Receptor protein at cytoplasm by immunofluorescent analysis.Sample: A375 cells were fixed in ice-cold MeOH for 5 min.Green: MC1 Receptor stained by MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:500.Blue: Fluoroshield with DAPI (GTX30920).
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GTX636945 IHC-Fr Image
MC1 Receptor antibody [HL1471] detects MC1 Receptor protein at cell membrane by immunohistochemical analysis.Sample: Frozen-sectioned mouse cerebellum.Green: MC1 Receptor stained by MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:100.Blue: Fluoroshield with DAPI (GTX30920).Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX636945 WB Image
Various tissue extracts (50 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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GTX636945 IHC-P Image
MC1 Receptor antibody [HL1471] detects MC1 Receptor protein at cell membrane by immunohistochemical analysis.Sample: Paraffin-embedded A375 xenograft .MC1 Receptor stained by MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX636945 WB Image
Various extracts (50 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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GTX636945 IHC-P Image
MC1 Receptor antibody [HL1471] detects MC1 Receptor protein at cell membrane and cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded mouse kidney.MC1 Receptor stained by MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:400.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX636945 IHC-P Image
MC1 Receptor antibody [HL1471] detects MC1 Receptor protein at cell membrane and cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded rat kidney.MC1 Receptor stained by MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:400.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX636945 IHC-P Image
MC1 Receptor antibody [HL1471] detects MC1 Receptor protein at cell membrane and cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded rat testis.MC1 Receptor stained by MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:400.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX636945 IHC-P Image
MC1 Receptor antibody [HL1471] detects MC1 Receptor protein at cell membrane and cytoplasm by immunohistochemical analysis.Sample: Paraffin-embedded mouse testis.MC1 Receptor stained by MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:400.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX636945 WB Image
Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with MC1 Receptor antibody [HL1471] (GTX636945) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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文献引用
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产品评论
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![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_45138_20230825_WB_shRNA_watermark_23083020_657.webp "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20230714_ICC_IF_23072519_672.webp "Anti-MC1 Receptor antibody [HL1471] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Frozen sections) (IHC-Fr). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20240126_IHC-Fr_M_24021917_594.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Frozen sections) (IHC-Fr). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20230616_WB_M_tissue_23062019_114.webp "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20230616_IHC-P_23062019_229.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20230707_WB_M_R_23071223_132.webp "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20230707_IHC-P_M_23071822_721.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20230707_IHC-P_R_23071822_756.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20230707_IHC-P_R_1_23071822_809.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_T-44662_20230707_IHC-P_M_1_23071822_648.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/upload/website/prouct_img/small/GTX636945/GTX636945_45138_20230818_WB_23082201_227.webp "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_45138_20230825_WB_shRNA_watermark_23083020_657.webp "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20230714_ICC_IF_23072519_672.webp "Anti-MC1 Receptor antibody [HL1471] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Frozen sections) (IHC-Fr). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20240126_IHC-Fr_M_24021917_594.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Frozen sections) (IHC-Fr). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20230616_WB_M_tissue_23062019_114.webp "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20230616_IHC-P_23062019_229.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20230707_WB_M_R_23071223_132.webp "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20230707_IHC-P_M_23071822_721.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20230707_IHC-P_R_23071822_756.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20230707_IHC-P_R_1_23071822_809.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_T-44662_20230707_IHC-P_M_1_23071822_648.webp "Anti-MC1 Receptor antibody [HL1471] used in IHC (Paraffin sections) (IHC-P). GTX636945")
![Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945](/upload/website/prouct_img/normal/GTX636945/GTX636945_45138_20230818_WB_23082201_227.webp "Anti-MC1 Receptor antibody [HL1471] used in Western Blot (WB). GTX636945")
