形式
Liquid
存储溶液
0.1M Tris, 0.1M Glycine, 10% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant protein encompassing a sequence within the center region of human MMP12. The exact sequence is proprietary.
纯化方式
Purified by antigen-affinity chromatography.
偶联
Unconjugated
RRID
AB_1950928
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
matrix metallopeptidase 12 , HME , ME , MME , MMP-12
细胞定位
Secreted , extracellular space , extracellular matrix
功能与背景
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
数据库
研究领域
![Anti-MMP12 antibody [N3C3] used in IHC (Paraffin sections) (IHC-P). GTX102928](/upload/website/prouct_img/small/GTX102928/GTX102928_IHC_w_23060119_666.webp "Anti-MMP12 antibody [N3C3] used in IHC (Paraffin sections) (IHC-P). GTX102928")
![Anti-MMP12 antibody [N3C3] used in Western Blot (WB). GTX102928](/upload/website/prouct_img/small/GTX102928/GTX102928_39974_20230303_WB_23030717_292.webp "Anti-MMP12 antibody [N3C3] used in Western Blot (WB). GTX102928")
![Anti-MMP12 antibody [N3C3] used in IHC (Paraffin sections) (IHC-P). GTX102928](/upload/website/prouct_img/normal/GTX102928/GTX102928_IHC_w_23060119_666.webp "Anti-MMP12 antibody [N3C3] used in IHC (Paraffin sections) (IHC-P). GTX102928")
![Anti-MMP12 antibody [N3C3] used in Western Blot (WB). GTX102928](/upload/website/prouct_img/normal/GTX102928/GTX102928_39974_20230303_WB_23030717_292.webp "Anti-MMP12 antibody [N3C3] used in Western Blot (WB). GTX102928")
