Mre11抗体 [12D7]
目录号 GTX70212
目录号 GTX70212
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宿主Mouse
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克隆Monoclonal
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克隆编号12D7
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同种型IgG1
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实验应用WB ICC/IF IP ELISA Functional Assay PLA
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种属反应Human
摘要
MRE11 antibody recognizes MRE11 protein, an enzyme with a predicted molecular weight of ~81 kDa. MRE11 forms the core of the MRN (MRE11-RAD50-NBS1) complex, one of the first components of the DNA damage response (DDR) to DNA double-strand breaks where it recruits other signaling factors required for repair. MRE11 has both exonuclease and endonuclease activities, and is responsible for the DNA binding of the complex.