Mre11抗体 [12D7]

Name: Mre11抗体 [12D7]
Brand: GeneTex
SKU: GTX70212
Price: 4300.00 RMB
Rating: 5 (2 reviews)

Anti-Mre11 antibody [12D7] used in Western Blot (WB). GTX70212

Anti-Mre11 antibody [12D7] used in IHC (Paraffin sections) (IHC-P). GTX70212

Anti-Mre11 antibody [12D7] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70212

目录号 GTX70212

文献引用 168

宿主	Mouse
克隆	Monoclonal
克隆编号	12D7
同种型	IgG1
实验应用	WB, ICC/IF, IHC-P, IP, ELISA, Functional Assay, PLA
种属反应	Human
产品包装	100 μl (¥4300)

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View product citations for antibody GTX70212 on CiteAb

产品说明

摘要

MRE11 antibody recognizes MRE11 protein, an enzyme with a predicted molecular weight of ~81 kDa. MRE11 forms the core of the MRN (MRE11-RAD50-NBS1) complex, one of the first components of the DNA damage response (DDR) to DNA double-strand breaks where it recruits other signaling factors required for repair. MRE11 has both exonuclease and endonuclease activities, and is responsible for the DNA binding of the complex.

产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认

实验应用	稀释倍数
WB	1:500-1:3000
ICC/IF	1:100-1:1000
IHC-P	Assay dependent
IP	Assay dependent
ELISA	Assay dependent
Functional Assay	Assay dependent
PLA	Assay dependent

WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

81 kDa. ( Note )

阳性对照

HeLa,Jurkat,Raji,NCI-H929,293T,human Mre11-transfected 293T

产品说明

我们不建议将此产品应用于 Mouse,Rat samples.

产品属性

形式

Liquid

存储溶液

PBS

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

0.45 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Amino acids 182-582 of Mre11 expressed in E. coli.

纯化方式

Protein G purified

偶联

Unconjugated

RRID

AB_372398

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

别名

MRE11 homolog, double strand break repair nuclease , ATLD , HNGS1 , MRE11A , MRE11B

细胞定位

Nucleus

功能与背景

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

数据库

Gene ID: 4361 MRE11
UniProt: P49959 MRE11

研究领域

產品图片

GTX70212 WB Image

Non-transfected (–) and transfected (+) HeLa whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Mre11 antibody [12D7] (GTX70212) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX70212 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membranes were blotted with Mre11 antibody [12D7] (GTX70212) diluted at 1:1000 and competitor's antibody diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

*The competitor is not affiliated with GeneTex and does not endorse this product.

GTX70212 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membranes were blotted with Mre11 antibody [12D7] (GTX70212) diluted at 1:1000 and competitor's antibody diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

*The competitor is not affiliated with GeneTex and does not endorse this product.

GTX70212 IHC-P Image

Mre11 antibody [12D7] detects Mre11 protein at nucleus by immunohistochemical analysis (Autostainer Formulated).
Sample: Paraffin-embedded human colon cancer.
Mre11 stained by Mre11 antibody [12D7] (GTX70212) diluted at 1:300.
Antigen Retrieval: EDTA buffer, 20 min

GTX70212 WB Image

Mre11 antibody [12D7] detects Mre11 protein by western blot analysis.
A. 30 μg 293T whole cell extract
B. 30 μg whole cell extract of human Mre11-transfected 293T cells
7.5% SDS-PAGE
Mre11 antibody [12D7] (GTX70212) dilution: 1:1000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX70212 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Mre11 antibody [12D7] (GTX70212) diluted at 1:500. The HRP-conjugated anti-mouset IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX70212 ICC/IF Image

Mre11 antibody [12D7] detects Mre11 protein at nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: Mre11 stained by Mre11 antibody [12D7] (GTX70212) diluted at 1:200.
Blue: Hoechst 33342 staining.
Scale bar= 10 μm.

GTX70212 ICC/IF Image

The data was published in the journal PLoS Pathog in 2010.PMID: 20949077

GTX70212 ICC/IF Image

The data was published in the journal J Virol in 2017.PMID: 28855246

GTX70212 ICC/IF Image

The data was published in the journal Viruses in 2015.PMID: 26057167

GTX70212 WB Image

The data was published in the journal BMC Biol in 2015. PMID: 25857663

GTX70212 ICC/IF Image

The data was published in the journal Nucleic Acids Res in 2016. PMID: 26446986

GTX70212 ICC/IF Image

The data was published in the journal Nucleic Acids Res in 2016. PMID: 26446986

GTX70212 WB Image

The data was published in the journal Nat Commun in 2017.PMID: 29042561

GTX70212 ICC/IF Image

The data was published in the journal Open Biol in 2015.PMID: 25924630

GTX70212 WB Image

The data was published in the journal BMC Cancer in 2014.PMID: 24928521

GTX70212 WB Image

The data was published in the journal PLoS One in 2015.PMID: 25826455

GTX70212 WB Image

The data was published in the journal Open Biol in 2015.PMID: 25924630

GTX70212 WB Image

The data was published in the journal Nat Commun in 2017.PMID: 29042561

文献引用

Application Reference

Zhang C et al. EMBO J 2024; 43 (1) : 61-86 YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.

A Nusawardhana et al. Nucleic Acids Res 2024; : gkad1237 USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress

实验应用 : ICC/IF

Zhang T et al. Nature 2023; 619 (7968) : 201-208 Break-induced replication orchestrates resection-dependent template switching.

Hale A et al. Nat Commun 2023; 14 (1) : 6265 Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases.

JE Packard et al. PLoS Pathog 2023; 19 (7) : e1011539 Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection

实验应用 : ICC/IF

种属反应 : Human

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我要回报文献

产品评论

Mre11 antibody [12D7] 目录号 GTX70212

Rating

( Average 5 based on 2 users reviews)

实验应用

Western Blot(WB)		( Average 5 based on 1 users reviews)
IHC (Paraffin sections)(IHC-P)		( Average 5 based on 1 users reviews)

Date : Anonymous submitted on 18-Aug-2021

Score :

Application Tested : WB

Sample Species : Hu

Sample : HaCaT cells

Amount used : 4 μg

Blocking : Skim milk, 25°C, 1Hr

Primary Antibody : 1:3000, 4°C, 11Hr

Date : Anonymous submitted on 21-Oct-2020

Score :

Application Tested : IHC-P

Sample Species : Hu

Sample : colon cancer tissue

Fixation : EDTA buffer, 0.3°C

Primary Antibody : 1:300, 4°C, 16Hr

我要评论产品

Application Reference

Zhang C et al. EMBO J 2024; 43 (1):61-86 YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.

A Nusawardhana et al. Nucleic Acids Res 2024;:gkad1237 USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress

实验应用 : ICC/IF

Zhang T et al. Nature 2023; 619 (7968):201-208 Break-induced replication orchestrates resection-dependent template switching.

Hale A et al. Nat Commun 2023; 14 (1):6265 Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases.

JE Packard et al. PLoS Pathog 2023; 19 (7):e1011539 Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection

实验应用 : ICC/IF

种属反应 : Human

Nguyen DD et al. Sci Adv 2023; 9 (19):eadd8023 Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.

Saha LK et al. Nat Commun 2023; 14 (1):1925 Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.

实验应用 : WB

种属反应 : Human

Trivedi P et al. Nature 2023; 618 (7967):1049-1056 Mitotic tethering enables inheritance of shattered micronuclear chromosomes.

Thakar T et al. Nat Commun 2022; 13 (1):5323 Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling.

实验应用 : WB

种属反应 : Human

Dhoonmoon A et al. Nat Commun 2022; 13 (1):5063 The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1.

实验应用 : PLA

种属反应 : Human

Josephine Mun Yee Ko et al. Cancers (Basel) 2021; 13 (18) RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma.

实验应用 : WB

种属反应 : Human

Xu X et al. Nat Commun 2021; 12 (1):3520 The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation.

实验应用 : WB

种属反应 : Human

Dubich T et al. J Mol Med (Berl) 2021; 99 (3):425-438 3D culture conditions support Kaposi's sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells.

实验应用 : WB

种属反应 : Human

Suzuki R et al. Nucleic Acids Res 2021; 49 (1):244-256 The fragility of a structurally diverse duplication block triggers recurrent genomic amplification.

实验应用 : ICC/IF

种属反应 : Human

Kiminori Kurashima et al. NAR Cancer 2020; 2 (2):zcaa005 SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma.

实验应用 : ICC/IF

种属反应 : Human

Yamashita R et al. Mutat Res 2020; 858-860:503273 Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair.

实验应用 : WB

种属反应 : Human

Bennett LG et al. Sci Adv 2020; 6 (28):eaba5974 MRNIP is a replication fork protection factor.

实验应用 : WB

种属反应 : Human

Duan H et al. J Cell Biol 2020; 219 (6) E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells.

Qi F et al. J Radiat Res 2020; 61 (3):368-375 FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses.

实验应用 : WB

种属反应 : Human

Ragamin A et al. Am J Med Genet A 2020; 182 (6):1378-1386 Human RAD50 deficiency: Confirmation of a distinctive phenotype.

实验应用 : WB

种属反应 : Human

Völkening L et al. FASEB J 2020; 34 (2):2812-2820 RAD50 regulates mitotic progression independent of DNA repair functions.

实验应用 : WB

种属反应 : Human

Mooser C et al. Nat Commun 2020; 11 (1):123 Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.

实验应用 : ICC/IF

种属反应 : Human

Lamarche BJ et al. DNA Repair (Amst) 2019; 74:80-90 Repair of protein-linked DNA double strand breaks: Using the adenovirus genome as a model substrate in cell-based assays.

Lorenson MY et al. Biol Methods Protoc 2019; 4 (1):bpy014 Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood.

Murata MM et al. Mol Biol Cell 2019; 30 (20):2584-2597 NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival.

Ly P et al. Nat Genet 2019; 51 (4):705-715 Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.

Godau J et al. DNA Repair (Amst) 2019; 77:96-108 Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair.

Sohn SY et al. MBio 2019; 10 (1):pii: e00022-19 Mechanism of Adenovirus E4-ORF3-Mediated SUMO Modifications.

实验应用 : WB

种属反应 : Human

Mary Y Lorenson et al. Biology Methods and Protocols 2019; 4 (1) Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood.

Burger K et al. Nucleic Acids Res 2019; (Epub) Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks.

Kong X et al. J Cell Sci 2018; 131 (23) Biphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repair.

Yizhou Joseph He et al. Nature 2018; (Epub) DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.

实验应用 : WB, IP

种属反应 : Human

Przetocka S et al. Mol Cell 2018; 72 (3):568-582.e6 CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress.

实验应用 : WB

种属反应 : Human

Fujiwara C et al. Sci Rep 2018; 8 (1):14827 Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.

实验应用 : WB

种属反应 : Human

Michael Murata et al. bioRxiv 2018; (Epub) NAD consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival.

实验应用 : ICC/IF

种属反应 : Human

Johnson TE et al. Cell Rep 2018; 24 (6):1471-1483 Homeodomain Proteins Directly Regulate ATM Kinase Activity.

实验应用 : WB

种属反应 : Human

Cai M et al. Int J Cancer 2018; (Epub) inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in *-resistant colon cancer cells.

实验应用 : WB

种属反应 : Human

Shou J et al. Mol Cell 2018; 71 (4):498-509.e4 Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion.

实验应用 : WB

种属反应 : Human

Kong X et al. bioRxiv 2018; (Epub) Biphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repair.

实验应用 : ICC/IF

种属反应 : Human

Park S et al. Mol Cancer Res 2018; (Epub) Therapeutic Effect of Quinacrine, an Anti-protozoan Drug, by Selective Suppression of p-CHK1/2 in p53-negative Malignant Cancers.

实验应用 : WB

种属反应 : Human

Ahmed KM et al. Mol Cell Biol 2018; (Epub) β1-integrin impacts Rad51 stability and DNA double-strand break repair by homologous recombination.

实验应用 : WB

种属反应 : Human

Hollingworth R et al. J Virol 2017; 91 (22) Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.

Mujoo K et al. Stem Cell Reports 2017; 9 (5):1660-1674 Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.

实验应用 : ICC/IF

种属反应 : Human

Taglialatela A et al. Mol Cell 2017; 68 (2):414-430.e8 Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.

实验应用 : PLA

种属反应 : Human

Lou J et al. Nat Commun 2017; 8 (1):985 AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.

实验应用 : WB

种属反应 : Human

Henrich SM et al. Sci Rep 2017; 7:41663 Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.

实验应用 : WB

种属反应 : Human

Smith EA et al. Sci Rep 2017; 7:44662 DEK is required for homologous recombination repair of DNA breaks.

实验应用 : WB

种属反应 : Human

Mattoo AR et al. Mol Cell Biol 2016; (Epub) MCL-1 depletion impairs DNA DSB repair and re-initiation of stalled DNA replication forks.

实验应用 : WB

种属反应 : Human

Johnson BA et al. Virology 2016; 500:22-34 The Rb binding domain of HPV31 E7 is required to maintain high levels of DNA repair factors in infected cells.

实验应用 : WB

种属反应 : Human

Lou DI et al. Cell Host Microbe 2016; 20 (2):178-88 An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.

实验应用 : WB

种属反应 : Human

Renaud E et al. Nucleic Acids Res 2016; 44 (2):648-56 Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.

Bowen C et al. Cancer Res 2015; 75 (13):2686-98 NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.

实验应用 : WB

种属反应 : Human

Markiewicz E et al. Open Biol 2015; 5 (4):150011 Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.

实验应用 : WB

种属反应 : Human

Kozlov SV et al. Mol Cell Proteomics 2015; (Epub) ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen.

实验应用 : WB

种属反应 : Human

Kijas AW et al. Nucleic Acids Res 2015; 43 (17):8352-67 ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.

实验应用 : WB

种属反应 : Human

Hollingworth R et al. Viruses 2015; 7 (6):2908-27 Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.

实验应用 : ICC/IF

种属反应 : Human

Nakajima NI et al. PLoS One 2015; 10 (3):e0122582 Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.

实验应用 : WB, ICC/IF

种属反应 : Human

Harten SK et al. BMC Biol 2015; 13:21 The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers.

实验应用 : WB

种属反应 : Human

Huang YL et al. Hum Mol Genet 2015; 24:3506-17 FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.

实验应用 : WB

种属反应 : Human

Schroder-Heurich B et al. BMC Cancer 2014; 14:434 Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line.

实验应用 : WB

种属反应 : Human

Pathania S et al. Nat Commun 2014; 5:5496 BRCA1 haploinsufficiency for replication stress suppression in primary cells.

实验应用 : ICC/IF

种属反应 : Human

Jian W et al. Anticancer Drugs 2014; Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage.

实验应用 : WB

种属反应 : Human

Zhou Y et al. Nucleic Acids Res 2014; 42 (3):e19 Quantitation of DNA double-strand break resection intermediates in human cells.

实验应用 : WB

种属反应 : Human

Schroder-Heurich B et al. FASEB J 2014; 28 (3):1331-41 Protective role of RAD50 on chromatin bridges during abnormal cytokinesis.

实验应用 : ICC/IF

Kong X et al. Mol Cell Biol 2014; 34 (4):685-98 Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair.

实验应用 : WB

O'Sullivan RJ et al. Nat Struct Mol Biol 2014; 21 (2):167-74 Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.

实验应用 : WB

种属反应 : Human

Simoes M et al. Vet Microbiol 2013; 165 (43102):140-7 Host DNA damage response facilitates African swine fever virus infection.

实验应用 : WB

Lee JH et al. J Biol Chem 2013; 288 (18):12840-51 Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

实验应用 : Functional Assay

Inagaki H et al. Nat Commun 2013; 4:1592 Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.

Stewart R et al. Hum Mol Genet 2013; 22 (12):2495-509 A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.

实验应用 : Functional Assay

Sohn SY et al. J Virol 2012; 86 (18):9656-65 Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.

Andrin C et al. Nucleus 2012; 3 (4):384-95 A requirement for polymerized actin in DNA double-strand break repair.

Harding SM et al. Cell Cycle 2012; 11 (7):1432-44 Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks.

Tomimatsu N et al. DNA Repair (Amst) 2012; 11 (4):441-8 Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.

Karen KA et al. J Virol 2011; 85 (9):4135-42 Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection.

实验应用 : ICC/IF

种属反应 : Human

Anderson VE et al. Cancer Res 2011; 71 (2):463-72 CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.

实验应用 : WB

种属反应 : Human

Matsumoto Y et al. DNA Repair (Amst) 2011; 10 (3):314-21 Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.

实验应用 : WB

种属反应 : Human

Luo Y et al. J Virol 2011; 85 (1):133-45 Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death.

实验应用 : ICC/IF

种属反应 : Human

Masuda Y et al. Biochem Biophys Res Commun 2011; 415 (2):305-12 Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin.

实验应用 : WB

种属反应 : Human

Yanagihara H et al. Mol Cell 2011; 43 (5):788-97 NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.

实验应用 : WB

种属反应 : Human

Della-Maria J et al. J Biol Chem 2011; 286 (39):33845-53 Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.

Gatei M et al. J Biol Chem 2011; 286 (36):31542-56 ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.

Baydoun HH et al. Blood 2011; 117 (22):5897-906 Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair.

实验应用 : ICC/IF

种属反应 : Human

Forrester NA et al. J Virol 2011; 85 (5):110244 Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.

实验应用 : ICC/IF

种属反应 : Human

Kozlov SV et al. J Biol Chem 2011; 286 (11):9107-19 Autophosphorylation and ATM activation: additional sites add to the complexity.

Orazio NI et al. J Virol 2011; 85 (4):1887-92 The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.

实验应用 : WB

种属反应 : Human

Adeyemi RO et al. PLoS Pathog 2010; 6 (10):e1001141 Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.

实验应用 : ICC/IF

种属反应 : Human

Balasubramanian N et al. J Virol 2010; 84 (24):12504-14 Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.

实验应用 : WB

Cha H et al. Cancer Res 2010; 70 (10):4112-22 Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.

Guo Z et al. Cell Cycle 2010; 9 (24):1061336 ATM activation in the presence of oxidative stress.

实验应用 : WB

Offer SM et al. PLoS One 2010; 5 (8):e12260 Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID.

实验应用 : WB

种属反应 : Human

Chailleux C et al. Biochem J 2010; 426 (3):365-71 Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.

实验应用 : WB

种属反应 : Human

Dellaire G et al. Cell Cycle 2009; 8 (22):3750-69 high resolution imaging of changes in the structure and spatial organization of chromatin, gamma-h2a.x and the mrn complex within *-induced dna repair foci.

实验应用 : WB

种属反应 : Human

Moody CA et al. PLoS Pathog 2009; 5 (10):e1000605 Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.

实验应用 : WB

种属反应 : Human

Turaga RV et al. Cell Cycle 2009; 8 (13):2080-92 The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.

实验应用 : WB

种属反应 : Human

Waltes R et al. Am J Hum Genet 2009; 84 (5):605-16 Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.

实验应用 : ICC/IF

种属反应 : Human

Schwartz RA et al. J Virol 2009; 83 (12):6269-78 Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase.

实验应用 : WB

种属反应 : Human

Zheng L et al. Nucleic Acids Res 2009; 37 (8):2645-57 MRE11 complex links RECQ5 helicase to sites of DNA damage.

实验应用 : WB

种属反应 : Human

Karen KA et al. J Virol 2009; 83 (9):4565-73 Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.

实验应用 : WB

种属反应 : Human

Moschos SJ et al. Cancer Biol Ther 2009; 8 (19):1815-25 Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation.

Lins S et al. Gene 2009; 447 (1):43441 Clinical variability and expression of the NBN c.657del5 allele in Nijmegen Breakage Syndrome.

实验应用 : WB

种属反应 : Human

Collaco RF et al. Virology 2009; 392 (1):24-33 Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.

实验应用 : ICC/IF

种属反应 : Human

Roques C et al. EMBO J 2009; 28 (16):2400-13 MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair.

实验应用 : WB

种属反应 : Human

Vago R et al. Cell Cycle 2009; 8 (16):255853 DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories.

实验应用 : WB

种属反应 : Human

Carlessi L et al. Cell Death Differ 2009; 16 (6):795-806 DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.

实验应用 : WB

种属反应 : Human

Zou Y et al. Mol Cell Biol 2009; 29 (9):179152 Altered states of telomere deprotection and the two-stage mechanism of replicative aging.

实验应用 : ICC/IF

Carson CT et al. EMBO J 2009; 28 (6):652-62 Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.

实验应用 : ICC/IF

种属反应 : Human

Crosby ME et al. Cancer Res 2009; 69 (3):1221-9 MicroRNA regulation of DNA repair gene expression in hypoxic stress.

实验应用 : WB

种属反应 : Human

Lakdawala SS et al. J Virol 2008; 82 (17):8362-72 Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.

实验应用 : ICC/IF

种属反应 : Human

Cervelli T et al. J Cell Sci 2008; 121 (Pt 3):349-57 Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.

实验应用 : ICC/IF

种属反应 : Human

Gregory DA et al. Virology 2008; 373 (1):124-36 Characterization of mre11 loss following HSV-1 infection.

实验应用 : ICC/IF

种属反应 : Human

Haince JF et al. J Biol Chem 2008; 283 (2):1197-208 PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites.

Palii SS et al. Mol Cell Biol 2008; 28 (2):752-71 DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

实验应用 : WB

种属反应 : Human

Dery U et al. Mol Cell Biol 2008; 28 (9):3058-69 A glycine-arginine domain in control of the human MRE11 DNA repair protein.

Schwartz RA et al. J Virol 2007; 81 (23):12936-45 The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.

实验应用 : ICC/IF

种属反应 : Human

Murakawa Y et al. Cancer Res 2007; 67 (18):8536-43 Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

实验应用 : ICC/IF

种属反应 : Human

Woo JL et al. J Virol 2007; 81 (2):575-87 Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.

实验应用 : WB

种属反应 : Human

Kruger L et al. Carcinogenesis 2007; 28 (1):107-11 Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.

实验应用 : WB

种属反应 : Human

Bentle MS et al. Cancer Res 2007; 67 (14):6936-45 Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.

实验应用 : ICC/IF

种属反应 : Human

Xu M et al. Int J Hyperthermia 2007; 23 (4):343-51 The effects of 41 degrees C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines.

Cho YW et al. J Biol Chem 2007; 282 (28):20395-406 PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

实验应用 : WB

种属反应 : Human

Fleisig HB et al. Oncogene 2007; 26 (33):4797-805 Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes.

Barcaroli D et al. Proc Natl Acad Sci U S A 2006; 103 (40):14802-7 FLASH is an essential component of Cajal bodies.

实验应用 : ICC/IF

种属反应 : Human

Barcaroli D et al. Proc Natl Acad Sci U S A 2006; 103 (40):14808-12 FLASH is required for histone transcription and S-phase progression.

实验应用 : ICC/IF

种属反应 : Human

Dote H et al. Cancer Res 2006; 66 (18):9211-20 Inhibition of hsp90 compromises the DNA damage response to radiation.

实验应用 : ICC/IF

种属反应 : Human

Nakanishi K et al. Arch Pathol Lab Med 2006; 130 (9):1330-4 Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung.

实验应用 : IHC-P

种属反应 : Human

Lovejoy CA et al. Mol Cell Biol 2006; 26 (21):7977-90 DDB1 maintains genome integrity through regulation of Cdt1.

实验应用 : ICC/IF

种属反应 : Human

Takemura H et al. J Biol Chem 2006; 281 (41):30814-23 Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

实验应用 : WB

种属反应 : Human

Kozlov SV et al. EMBO J 2006; 25 (15):3504-14 Involvement of novel autophosphorylation sites in ATM activation.

实验应用 : WB

种属反应 : Human

Bekker-Jensen S et al. J Cell Biol 2006; 173 (2):195-206 Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.

实验应用 : ICC/IF

种属反应 : Human

Gueven N et al. Cancer Res 2006; 66 (6):368135 Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.

实验应用 : WB

种属反应 : Human

Varon R et al. Hum Mol Genet 2006; 15 (5):679-89 Mild Nijmegen breakage syndrome phenotype due to alternative splicing.

实验应用 : WB

种属反应 : Human

Chai W et al. EMBO Rep 2006; 7 (2):225-30 The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres.

实验应用 : WB

种属反应 : Human

Vo AT et al. EMBO Rep 2005; 6 (5):438-44 hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.

实验应用 : WB

种属反应 : Human

Lilley CE et al. Proc Natl Acad Sci U S A 2005; 102 (16):1440762 DNA repair proteins affect the lifecycle of herpes simplex virus 1.

实验应用 : ICC/IF

种属反应 : Human

Hart LS et al. J Biol Chem 2005; 280 (2):1474-81 The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner.

实验应用 : WB

种属反应 : Human

Al Rashid ST et al. Cancer Res 2005; 65 (23):10810-21 Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.

实验应用 : ICC/IF

种属反应 : Human

Kim JS et al. J Cell Biol 2005; 170 (3):341-7 Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.

实验应用 : ICC/IF

种属反应 : Human

van Veelen LR et al. Mutat Res 2005; 574 (43102):22-33 Analysis of ionizing radiation-induced foci of DNA damage repair proteins.

实验应用 : ICC/IF

Fan R et al. Cancer Res 2004; 64 (23):8526-33 Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.

实验应用 : WB

种属反应 : Human

Zhang X et al. Mol Cell Biol 2004; 24 (20):9207-20 Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

实验应用 : WB

种属反应 : Human

Pichierri P et al. EMBO J 2004; 23 (15):3154-63 BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.

实验应用 : ICC/IF

种属反应 : Human

Robison JG et al. J Biol Chem 2004; 279 (33):34802-10 Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks.

实验应用 : ICC/IF

种属反应 : Human

Wilkinson DE et al. J Virol 2004; 78 (9):4783-96 Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.

实验应用 : WB

Dork T et al. Am J Med Genet A 2004; 126A (3):272-7 Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.

实验应用 : WB

Giannini G et al. Oncogene 2004; 23 (15):270463 Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.

实验应用 : ICC/IF

种属反应 : Human

Horejsi Z et al. Oncogene 2004; 23 (17):446509 Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.

实验应用 : ICC/IF

Stewart GS et al. Nature 2003; 421 (6926):961-6 MDC1 is a mediator of the mammalian DNA damage checkpoint.

Lukas C et al. Nat Cell Biol 2003; 5 (3):255-60 Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.

Xu X et al. J Biol Chem 2003; 278 (10):8795-803 NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.

实验应用 : ICC/IF

种属反应 : Human

Carson CT et al. EMBO J 2003; 22 (24):6610-20 The Mre11 complex is required for ATM activation and the G2/M checkpoint.

实验应用 : WB

种属反应 : Human

Uziel T et al. EMBO J 2003; 22 (20):5612-21 Requirement of the MRN complex for ATM activation by DNA damage.

实验应用 : ICC/IF

种属反应 : Human

Xu X et al. FASEB J 2003; 17 (13):1842-8 NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.

实验应用 : ICC/IF

种属反应 : Human

Gottwein E et al. J Virol 2003; 77 (17):9474-85 The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release.

Lee JH et al. Mol Cancer Res 2003; 1 (9):674-81 Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

实验应用 : ICC/IF

种属反应 : Human

Celeste A et al. Nat Cell Biol 2003; 5 (7):675-9 Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Her C et al. DNA Repair (Amst) 2002; 1 (9):719-29 Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1.

Nakanishi K et al. Nat Cell Biol 2002; 4 (12):913-20 Interaction of FANCD2 and NBS1 in the DNA damage response.

Richie CT et al. Mol Cell Biol 2002; 22 (24):8635-47 hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.

实验应用 : ICC/IF

种属反应 : Human

Pichierri P et al. Hum Mol Genet 2002; 11 (21):2531-46 DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.

实验应用 : WB

Kim JS et al. J Biol Chem 2002; 277 (47):45149-53 Specific recruitment of human cohesin to laser-induced DNA damage.

实验应用 : ICC/IF

种属反应 : Human

Xu M et al. Int J Hyperthermia 2002; 18 (5):385-403 Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1 degrees C and its effect on DNA repair.

Stracker TH et al. Nature 2002; 418 (6895):348-52 Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.

实验应用 : ICC/IF

种属反应 : Human

Limoli CL et al. Proc Natl Acad Sci U S A 2002; 99 (1):233-8 UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.

实验应用 : ICC/IF

种属反应 : Human

Gatei M et al. Nat Genet 2000; 25 (1):115-9 ATM-dependent phosphorylation of nibrin in response to radiation exposure.

Wang Y et al. Genes Dev 2000; 14 (8):927-39 BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

实验应用 : ICC/IF

种属反应 : Human

Harfst E et al. Mol Immunol 2000; 37 (15):915-29 Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.

实验应用 : WB

Lombard DB et al. Cancer Res 2000; 60 (9):157511 Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres.

实验应用 : ICC/IF

种属反应 : Human

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Mre11抗体 [12D7]

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