产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 1:1000 |
| 1:100 |
| 1:50 |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
产品属性
形式
Liquid
存储溶液
PBS, 1% BSA, 50% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1
纯化方式
Purified IgG
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
notch receptor 1 , AOS5 , AOVD1 , TAN1 , hN1
细胞定位
Cell membrane
功能与背景
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia.
数据库
研究领域
產品图片
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/templates/default/js/lightbox/images/loading.gif "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
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GTX84019 IHC-P Image
IHC-P analysis of breast tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of colon adenocarcinoma tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of human ovary adenocarcinoma tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 WB Image
WB analysis of wild type and NOTCH1 knock out HeLa cell lysate(10μg per lane) using GTX84019 NOTCH1 antibody [3E12].
Dilution : 1:500
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GTX84019 WB Image
WB analysis of HEK293T cells transfected with NOTCH1 plasmid (Right) or empty vector (Left) for 48 hrs using GTX84019 NOTCH1 antibody [3E12].
Loading : 5 ug per lane
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GTX84019 IHC-P Image
IHC-P analysis of kidney tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of kidney carcinoma tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of endometrium tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of breast adenocarcinoma tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of pancreas carcinoma tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of thyroid tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of lung carcinoma tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 ICC/IF Image
ICC/IF analysis of HepG2 cells using GTX84019 NOTCH1 antibody [3E12].
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GTX84019 ICC/IF Image
ICC/IF analysis of HeLa cells transiently transfected with NOTCH1 plasmid using GTX84019 NOTCH1 antibody [3E12].
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GTX84019 IHC-P Image
IHC-P analysis of lung tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of colon tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of thyroid carcinoma tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 IHC-P Image
IHC-P analysis of pancreas tissue using GTX84019 NOTCH1 antibody [3E12].
Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100ºC for 10min.
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GTX84019 ICC/IF Image
ICC/IF analysis of HT29 cells using GTX84019 NOTCH1 antibody [3E12].
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文献引用
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产品评论
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![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2167_IHC-P_w_23061420_209.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2165_IHC-P_w_23061420_778.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2166_IHC-P_w_23061420_822.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Western Blot (WB). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_4064_20181228_WB_w_23061420_561.webp "Anti-NOTCH1 antibody [3E12] used in Western Blot (WB). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Western Blot (WB). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_4065_WB_w_23061420_461.webp "Anti-NOTCH1 antibody [3E12] used in Western Blot (WB). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2174_IHC-P_w_23061420_667.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2168_IHC-P_w_23061420_180.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2173_IHC-P_w_23061420_848.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2164_IHC-P_w_23061420_289.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2170_IHC-P_w_23061420_781.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2177_IHC-P_w_23061420_260.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2169_IHC-P_w_23061420_602.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_910_ICCIF_w_23061420_180.webp "Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_909_ICCIF_w_23061420_300.webp "Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2175_IHC-P_w_23061420_727.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2172_IHC-P_w_23061420_656.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2171_IHC-P_w_23061420_854.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_2176_IHC-P_w_23061420_492.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019](/upload/website/prouct_img/small/GTX84019/GTX84019_911_ICCIF_w_23061420_716.webp "Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2167_IHC-P_w_23061420_209.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2165_IHC-P_w_23061420_778.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2166_IHC-P_w_23061420_822.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Western Blot (WB). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_4064_20181228_WB_w_23061420_561.webp "Anti-NOTCH1 antibody [3E12] used in Western Blot (WB). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Western Blot (WB). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_4065_WB_w_23061420_461.webp "Anti-NOTCH1 antibody [3E12] used in Western Blot (WB). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2174_IHC-P_w_23061420_667.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2168_IHC-P_w_23061420_180.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2173_IHC-P_w_23061420_848.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2164_IHC-P_w_23061420_289.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2170_IHC-P_w_23061420_781.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2177_IHC-P_w_23061420_260.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2169_IHC-P_w_23061420_602.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_910_ICCIF_w_23061420_180.webp "Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_909_ICCIF_w_23061420_300.webp "Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2175_IHC-P_w_23061420_727.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2172_IHC-P_w_23061420_656.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2171_IHC-P_w_23061420_854.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_2176_IHC-P_w_23061420_492.webp "Anti-NOTCH1 antibody [3E12] used in IHC (Paraffin sections) (IHC-P). GTX84019")
![Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019](/upload/website/prouct_img/normal/GTX84019/GTX84019_911_ICCIF_w_23061420_716.webp "Anti-NOTCH1 antibody [3E12] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX84019")
