形式
Liquid
存储溶液
PBS, 0.05% BSA, 50% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, we recommend adding 50% glycerol, then aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
2 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
A synthesized peptide derived from human Notch1
纯化方式
Purified by antigen-affinity chromatography
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
notch receptor 1 , AOS5 , AOVD1 , TAN1 , hN1
细胞定位
Cell membrane
功能与背景
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
数据库
研究领域
![Anti-NOTCH1 antibody [GT1224] used in Western Blot (WB). GTX02821](/upload/website/prouct_img/small/GTX02821/GTX02821_4000000285_20210122_WB_w_23053123_918.webp "Anti-NOTCH1 antibody [GT1224] used in Western Blot (WB). GTX02821")
![Anti-NOTCH1 antibody [GT1224] used in Immunoprecipitation (IP). GTX02821](/upload/website/prouct_img/small/GTX02821/CutImage_A19090_IP_01_(1071532)_w_23053122_112.webp "Anti-NOTCH1 antibody [GT1224] used in Immunoprecipitation (IP). GTX02821")
![Anti-NOTCH1 antibody [GT1224] used in Western Blot (WB). GTX02821](/upload/website/prouct_img/small/GTX02821/CutImage_A19090_WB_01_(1068949)_w_23053123_379.webp "Anti-NOTCH1 antibody [GT1224] used in Western Blot (WB). GTX02821")
![Anti-NOTCH1 antibody [GT1224] used in Western Blot (WB). GTX02821](/upload/website/prouct_img/normal/GTX02821/GTX02821_4000000285_20210122_WB_w_23053123_918.webp "Anti-NOTCH1 antibody [GT1224] used in Western Blot (WB). GTX02821")
![Anti-NOTCH1 antibody [GT1224] used in Immunoprecipitation (IP). GTX02821](/upload/website/prouct_img/normal/GTX02821/CutImage_A19090_IP_01_(1071532)_w_23053122_112.webp "Anti-NOTCH1 antibody [GT1224] used in Immunoprecipitation (IP). GTX02821")
![Anti-NOTCH1 antibody [GT1224] used in Western Blot (WB). GTX02821](/upload/website/prouct_img/normal/GTX02821/CutImage_A19090_WB_01_(1068949)_w_23053123_379.webp "Anti-NOTCH1 antibody [GT1224] used in Western Blot (WB). GTX02821")
