产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 0.2-2.5 ug/ml |
| 2-10 ug/ml |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
阳性对照
HCT116 , MCF-7
产品属性
形式
Liquid
存储溶液
PBS, 2% Sucrose
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
A synthetic peptide corresponding to an Internal region of Human PCBP1
纯化方式
Affinity Purified
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
poly(rC) binding protein 1 , HEL-S-85 , HNRPE1 , HNRPX , hnRNP-E1 , hnRNP-X
细胞定位
Nucleus,Cytoplasm
功能与背景
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
数据库
研究领域
產品图片
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GTX47349 IHC-P Image
IHC-P analysis of human spleen tissue using GTX47349 PCBP1 antibody at 5μg/ml.
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GTX47349 WB Image
WB analysis of HCT116 cells using GTX47349 PCBP1 antibody at 1μg/ml.
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GTX47349 IHC-P Image
IHC-P analysis of human breast tissue using GTX47349 PCBP1 antibody at 5μg/ml.
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GTX47349 WB Image
WB analysis of MCF-7 cells using GTX47349 PCBP1 antibody at 1.0μg/ml.
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