产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
预测种属反应
Human, Rat, Rabbit, Bovine, Dog, Pig, Rhesus Monkey(>80% identity)
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Carrier-protein conjugated synthetic peptide surrounding phospho Ser16 of human phospholamban . The exact sequence is proprietary
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
phospholamban , CMD1P , CMH18 , PLB
细胞定位
Endoplasmic reticulum membrane,Membrane
功能与背景
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
数据库
研究领域
產品图片
![Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309](/templates/default/js/lightbox/images/loading.gif "Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309")
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GTX637309 WB Image
Untreated (–) and treated (+) Mouse tissue extract (50 μg) were separated by 15% SDS-PAGE, and the membrane was blotted with Phospholamban (phospho Ser16) antibody [HL1710] (GTX637309) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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文献引用
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产品评论
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![Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309](/upload/website/prouct_img/small/GTX637309/GTX637309_T-44774_20221021_WB_M_treatment_peptideblocking_22102723_675.webp "Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309")
![Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309](/upload/website/prouct_img/normal/GTX637309/GTX637309_T-44774_20221021_WB_M_treatment_peptideblocking_22102723_675.webp "Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309")
