产品说明
摘要
The progesterone receptor (PR) is a well-known estrogen receptor (ER) target gene that is expressed in over two-thirds of ER-positive breast cancers. PR protein has a predicted molecular weight of 99kDa. It acts as a transcriptional regulator and activator of signal transduction pathways (i.e., MAPK, PI3K/Akt, and c-Src) that can drive proliferative signaling in breast cancer cells.
产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| 1:100-1:1000 |
| 1:100-1:1000 |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
预测种属反应
Chimpanzee, Rhesus Monkey(>80% identity)
产品属性
形式
Liquid
存储溶液
0.1M Tris, 0.1M Glycine, 10% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
0.33 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Progesterone Receptor. The exact sequence is proprietary.
纯化方式
Purified by antigen-affinity chromatography.
偶联
Unconjugated
RRID
AB_2037757
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
progesterone receptor , NR3C3 , PR
细胞定位
Nucleus , Cytoplasm , Isoform A: Nucleus
功能与背景
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined. [provided by RefSeq]
数据库
研究领域
產品图片
![Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051](/templates/default/js/lightbox/images/loading.gif "Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051")
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GTX116051 IHC-P Image
Immunohistochemical analysis of paraffin-embedded human breast cancer using Progesterone Receptor antibody (GTX116051) diluted at 1:500.
Representative data showing negative staining in PR-negative breast cancer (left) and nuclear staining in PR-positive breast cancer (right).
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX116051 ICC/IF Image
Immunofluorescence analysis of paraformaldehyde-fixed A549, using Progesterone receptor(GTX116051) antibody at 1:200 dilution.
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GTX116051 IHC-P Image
Immunohistochemical analysis of paraffin-embedded A549 xenograft, using Progesterone receptor(GTX116051) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min
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文献引用
产品评论
目前没有使用 Progesterone Receptor antibody [N1], N-term (GTX116051) 的产品评论被收录。快发表第一篇产品评论吧！
![Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051](/upload/website/prouct_img/small/GTX116051/GTX116051_40135_20160307_IHC-P_w_23060519_201.webp "Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051")
![Anti-Progesterone Receptor antibody [N1], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX116051](/upload/website/prouct_img/small/GTX116051/GTX116051_IFA_w_23060519_971.webp "Anti-Progesterone Receptor antibody [N1], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX116051")
![Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051](/upload/website/prouct_img/small/GTX116051/GTX116051_IHC_w_23060519_764.webp "Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051")
![Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051](/upload/website/prouct_img/normal/GTX116051/GTX116051_40135_20160307_IHC-P_w_23060519_201.webp "Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051")
![Anti-Progesterone Receptor antibody [N1], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX116051](/upload/website/prouct_img/normal/GTX116051/GTX116051_IFA_w_23060519_971.webp "Anti-Progesterone Receptor antibody [N1], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX116051")
![Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051](/upload/website/prouct_img/normal/GTX116051/GTX116051_IHC_w_23060519_764.webp "Anti-Progesterone Receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX116051")
