Rad51抗体 [14B4]

Name: Rad51抗体 [14B4]
Brand: GeneTex
SKU: GTX70230
Price: 4300.00 RMB
Rating: 4 (1 reviews)

Anti-Rad51 antibody [14B4] used in Immunoprecipitation (IP). GTX70230

Anti-Rad51 antibody [14B4] used in Western Blot (WB). GTX70230

Anti-Rad51 antibody [14B4] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70230

Anti-Rad51 antibody [14B4] used in IHC (Paraffin sections) (IHC-P). GTX70230

Anti-Rad51 antibody [14B4] used in Immunohistochemistry (IHC). GTX70230

目录号 GTX70230

文献引用 100

宿主	Mouse
克隆	Monoclonal
克隆编号	14B4
同种型	IgG2a
实验应用	WB, ICC/IF, IHC-P, IP, IHC, PLA
种属反应	Human, Mouse, Rat, Chicken
产品包装	100 μl (¥4300)

查看所有 Rad51 的产品

View product citations for antibody GTX70230 on CiteAb

产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认

实验应用	稀释倍数
WB	1:500-1:3000
ICC/IF	1:100-1:1000
IHC-P	1:100-1:1000
IP	Assay dependent
IHC	Assay dependent
PLA	Assay dependent

WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

37 kDa. ( Note )

阳性对照

Neuro2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , PC-12 , Rat-2

产品属性

形式

Liquid

存储溶液

PBS

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

1 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Full length (amino acids 1-338) Rad51 expressed in E. coli.

纯化方式

Purified by antigen-affinity chromatography.

偶联

Unconjugated

RRID

AB_372856

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

别名

RAD51 recombinase , BRCC5 , FANCR , HRAD51 , HsRad51 , HsT16930 , MRMV2 , RAD51A , RECA

细胞定位

Nucleus , Cytoplasm , Mitochondrion matrix

功能与背景

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

数据库

Gene ID: 5888 RAD51
UniProt: Q06609 RAD51

研究领域

產品图片

GTX70230 IP Image

Mouse anti-RAD51 14B4 antibody (GTX70230) was used in IP assay (immunoprecipitation) using HeLa cell extract prepared with lysis 180 buffer (40 mM Tris-HCl pH8.0, 180 mM NaCl, 1 mMEDTA, 0.5% NP-40).
Rabbit anti-RAD51 antibody (GTX100469) was used for subsequent WB detection of immunoprecipated RAD51.
Whole cell extract was used as input.

GTX70230 WB Image

Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX70230 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at 1:500. The HRP-conjugated anti-mouset IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

GTX70230 ICC/IF Image

Immunofluorecent staning of RAD51 nuclear foci in U2OS cells using RAD51 14B4 antibody (GTX70230).
Cells were pre-extracted with CSK buffer before fixation with 4% PFA.
RAD51 14B4 was used at 1:1000 dultion. DAPI was used to counterstain the nucleus.
Scale bar, 10 mciro-meter.

GTX70230 ICC/IF Image

Rad51 antibody [14B4] detects Rad51 protein at nuclear foci by immunofluorescent analysis.
Sample: Mock and treated HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: Rad51 stained by Rad51 antibody [14B4] (GTX70230) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).

GTX70230 IHC-P Image

RAD51 antibody 14B4 (GTX70230) detects RAD51 in nucleus on BT483 xenograft by immunohistochemical analysis.
Sample: Paraffin-embedded BT483 xenograft.
RAD51 antibody 14B4 (GTX702308) dilution: 1:200.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

GTX70230 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4] (GTX70230) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

GTX70230 IHC Image

The data was published in the journal Oncotarget in 2019.PMID: 31080552

GTX70230 ICC/IF Image

The data was published in the journal Nat Commun in 2016.PMID: 26727879

GTX70230 WB Image

The data was published in the journal EMBO Mol Med in 2013. PMID: 23341130

GTX70230 WB Image

The data was published in the journal EMBO Mol Med in 2013. PMID: 23341130

GTX70230 WB Image

The data was published in the journal EMBO Mol Med in 2013. PMID: 23341130

GTX70230 WB Image

The data was published in the journal Mol Oncol in 2017. PMID: 28173629

GTX70230 WB Image

The data was published in the 2017 in Cell. PMID: 28575672

GTX70230 ICC/IF Image

The data was published in the journal Oncogene in 2019. PMID: 30177840

GTX70230 ICC/IF Image

The data was published in the journal Oncogene in 2019. PMID: 30177840

GTX70230 WB Image

The data was published in the journal Elife in 2018.PMID: 29985131

GTX70230 ICC/IF Image

The data was published in the journal Nat Commun in 2016.PMID: 26727879

GTX70230 ICC/IF Image

The data was published in the journal PLoS One in 2014. PMID: 25310191

GTX70230 IHC-P Image

The data was published in the journal Int J Radiat Oncol Biol Phys in 2016.PMID: 27020103

GTX70230 WB Image

The data was published in the journal Mol Oncol in 2017. PMID: 28173629

GTX70230 WB Image

The data was published in the journal Mol Oncol in 2017. PMID: 28173629

GTX70230 WB Image

The data was published in the journal Mol Oncol in 2017. PMID: 28173629

文献引用

Application Reference

Schwarz B et al. Int J Mol Sci 2024; 25 (1) Chromatin Organization after High-LET Irradiation Revealed by Super-Resolution STED Microscopy.

YY Wang et al. Int J Oncol 2024; 64 (2) : 12 Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis

实验应用 : IHC-P

Li J et al. Transl Oncol 2024; 39 : 101825 Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer.

Yuan M et al. J Nanobiotechnology 2023; 21 (1) : 393 A carrier-free supramolecular nano-twin-drug for overcoming irinotecan-resistance and enhancing efficacy against colorectal cancer.

Lin IC et al. Cells 2023; 12 (19) Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.

显示更多 +

我要回报文献

产品评论

Rad51 antibody [14B4] 目录号 GTX70230

Rating

( Average 4 based on 1 users reviews)

实验应用

Western Blot(WB)

( Average 4 based on 1 users reviews)

Date : Anonymous submitted on 23-Nov-2018

Score :

Application Tested : WB

Sample Species : Hu

Sample : AGS cells

Amount used : 80 μg

Blocking : 5% milk, 25°C, 1Hr

Primary Antibody : 1:1000, 25°C, 1.5Hr

我要评论产品

Application Reference

Schwarz B et al. Int J Mol Sci 2024; 25 (1) Chromatin Organization after High-LET Irradiation Revealed by Super-Resolution STED Microscopy.

YY Wang et al. Int J Oncol 2024; 64 (2):12 Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis

实验应用 : IHC-P

Li J et al. Transl Oncol 2024; 39:101825 Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer.

Yuan M et al. J Nanobiotechnology 2023; 21 (1):393 A carrier-free supramolecular nano-twin-drug for overcoming irinotecan-resistance and enhancing efficacy against colorectal cancer.

van Wijk LM et al. Breast Cancer Res Treat 2023; 202 (3):607-616 Performance of a RAD51-based functional HRD test on paraffin-embedded breast cancer tissue.

Lin IC et al. Cells 2023; 12 (19) Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.

J Vollmer et al. J Neurooncol 2023; Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells

实验应用 : WB

Park J et al. NAR Cancer 2023; 5 (3):zcad050 INHAT subunit SET/TAF-Iβ regulates PRC1-independent H2AK119 mono-ubiquitination via E3 ligase MIB1 in colon cancer.

Miaomiao Yuan et al. Research Square 2023; A Carrier-Free Supramolecular Nano-Twin-Drug for Overcoming Irinotecan- Resistance and Enhancing Efficacy against Colorectal Cancer

实验应用 : ICC/IF

Ter Brugge P et al. Nat Commun 2023; 14 (1):1958 Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers.

实验应用 : IHC-P

种属反应 : Mouse

Capala ME et al. Cancers (Basel) 2023; 15 (2) Ex Vivo Functional Assay for Evaluating Treatment Response in Tumor Tissue of Head and Neck Squamous Cell Carcinoma.

Lu X et al. J Exp Clin Cancer Res 2022; 41 (1):355 CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors.

Cheng YW et al. J Oncol 2022; 2022:7250278 miR-3059-3p Regulates Glioblastoma Multiforme Radiosensitivity Enhancement through the Homologous Recombination Pathway of DNA Repair.

Tanaka K et al. Sci Rep 2022; 12 (1):14764 Activation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation.

Heijink AM et al. Nat Commun 2022; 13 (1):6722 Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51.

实验应用 : WB

种属反应 : Human

Tsaridou S et al. EMBO Rep 2022; 23 (8):e54483 53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling.

实验应用 : ICC/IF

种属反应 : Human

Zimmerli D et al. Nat Commun 2022; 13 (1):6579 MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling.

Durinikova E et al. Clin Cancer Res 2022; 28 (17):3874-3889 Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Anna R Michmerhuizen et al. NPJ Breast Cancer 2022; 8 (1):31 Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models.

实验应用 : ICC/IF

种属反应 : Human

Cosgrove N et al. Nat Commun 2022; 13 (1):514 Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities.

实验应用 : IHC-P

种属反应 : Human

Wang SA et al. Cell Death Differ 2021; USP24 promotes drug resistance during cancer therapy.

Jiehui Deng et al. Nat Cancer 2021; 2 (5):503-514 ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer.

实验应用 : WB

种属反应 : Human

Lise M van Wijk et al. Cancers (Basel) 2021; 13 (12) The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks.

实验应用 : IHC-P

种属反应 : Human

Pesch AM et al. JCI Insight 2021; (Epub) RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes.

实验应用 : ICC/IF

种属反应 : Human

Lee M et al. Nucleic Acids Res 2021; 49 (10):5588-5604 Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance.

实验应用 : WB

种属反应 : Human

Bold I.T. et al. Cancers 2021; 13 (6):1194 DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients.

实验应用 : WB

Zhu Y et al. Prostate 2021; 81 (1):81-88 CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.

实验应用 : ICC/IF

种属反应 : Human

Coussy F et al. Sci Transl Med 2020; 12 (531) BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers.

Liang ML et al. Cancers (Basel) 2020; 12 (12) Abemaciclib, A Selective CDK4/6 Inhibitor, Restricts the Growth of Pediatric Ependymomas.

实验应用 : WB

种属反应 : Human

Du Y et al. ACS Appl Mater Interfaces 2020; 12 (51):56874-56885 Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer.

实验应用 : WB

种属反应 : Human

van Wijk LM et al. Cancers (Basel) 2020; 12 (10) The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.

Chopra N et al. Nat Commun 2020; 11 (1):2662 Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.

实验应用 : IHC-P

种属反应 : Human

Hu Z et al. EMBO J 2020; 39 (12):e104133 BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.

实验应用 : WB

种属反应 : Human

Meyer F et al. Cells 2020; 9 (1) Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer.

实验应用 : WB

Neuh?user K et al. Clin Transl Radiat Oncol 2019; 15:99-107 Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling.

Perl AL et al. J Biol Chem 2019; 294 (45):17043-17059 Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45).

实验应用 : ICC/IF

种属反应 : Mouse

Krajewska M et al. Nat Commun 2019; 10 (1):1757 CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.

Heijink AM et al. Cell Rep 2019; 28 (9):2345-2357.e5

实验应用 : ICC/IF

种属反应 : Human

Kopper O et al. Nat Med 2019; 25 (5):838-849 An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.

实验应用 : ICC/IF

种属反应 : Human

Ordonez LD et al. Oncotarget 2019; 10 (27):2586-2606 Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.

实验应用 : ICC/IF

Heijink AM et al. Nat Commun 2019; 10 (1):100 BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

实验应用 : ICC/IF

种属反应 : Human

Marzio A et al. Mol Cell 2019; 73 (2):224-237.e6 The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.

实验应用 : WB

种属反应 : Human

Mansour WY et al. Sci Rep 2018; 8 (1):3947 Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.

Rona G et al. Elife 2018; 7 PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading.

Johnson TI et al. Cell Death Dis 2018; 9 (9):913 Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation.

van den Tempel N et al. PLoS One 2018; 13 (12):e0209101 Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder.

实验应用 : IHC-P

种属反应 : Human

Chen CC et al. Cancers (Basel) 2018; 10 (9) Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair.

实验应用 : WB, ICC/IF

种属反应 : Human

van Gijn SE et al. Oncogene 2018; (Epub) TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells.

实验应用 : ICC/IF

种属反应 : Human

Chen CC et al. Cell Death Dis 2018; 9 (5):543 Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair.

实验应用 : WB

种属反应 : Human

Baranes-Bachar K et al. Mol Cell 2018; 69 (5):866-878.e7 The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

实验应用 : ICC/IF

种属反应 : Human

Schoonen PM et al. Nat Commun 2017; 8:15981 Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.

实验应用 : WB, ICC/IF

种属反应 : Human

Kalimutho M et al. Mol Oncol 2017; 11 (5):470-490 Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.

Briest F et al. Neuroendocrinology 2017; (Epub) Mechanisms of targeting the MDM2-p53-FOXM1 axis in well-differentiated intestinal neuroendocrine tumors.

实验应用 : WB

种属反应 : Human

Tan SLW et al. Cell 2017; 169 (6):1105-1118.e15 A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.

实验应用 : WB

种属反应 : Human

Browning CL et al. Toxicol Appl Pharmacol 2017; (Epub) Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins.

实验应用 : PLA

Weeden CE et al. PLoS Biol 2017; 15 (1):e2000731 Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway.

实验应用 : IHC-P

种属反应 : Human, Mouse

Reindl J et al. Sci Rep 2017; 7:40616 Chromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci.

实验应用 : ICC/IF

种属反应 : Human

Tan W et al. Cancer Med 2017; (Epub) Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks.

实验应用 : ICC/IF

种属反应 : Human

Jiang Y et al. Int J Radiat Oncol Biol Phys 2016; 95 (2):772-81 Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.

实验应用 : IHC-P

种属反应 : Human

Zhang H et al. Nat Commun 2016; 7:10201 A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.

实验应用 : ICC/IF

种属反应 : Human

Magnus T. Dillon et al. Mol. Cancer Ther. 2016; (Epub) Radiosensitization by the ATR inhibitor AZD6738 through generation of acentric micronuclei.

实验应用 : IHC-P

种属反应 : Human

Bhide SA et al. Br J Cancer 2016; 115 (7):825-30 Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.

实验应用 : IHC-P

种属反应 : Human

Schaaf L et al. Cancer Res 2016; (Epub) Hyperthermia synergizes with chemotherapy by inhibiting PARP1-dependent DNA replication arrest.

实验应用 : ICC/IF

种属反应 : Human

Boucher D et al. FASEB J 2015; 29 (8):3326-34 Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice.

实验应用 : ICC/IF

种属反应 : Mouse

Bowen C et al. Cancer Res 2015; 75 (13):2686-98 NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.

实验应用 : WB

种属反应 : Human

Luo K et al. Nucleic Acids Res 2015; 43 (11):5465-75 CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase.

实验应用 : ICC/IF

种属反应 : Human

Magin S et al. Mol Cancer Ther 2015; 14 (6):1424-33 Inhibition of Homologous Recombination and Promotion of Mutagenic Repair of DNA Double-Strand Breaks Underpins Arabinoside-Nucleoside Analogue Radiosensitization.

实验应用 : ICC/IF

种属反应 : Human

Kausar T et al. Neoplasia 2015; 17 (10):757-66 sensitization of pancreatic cancers to * chemoradiation by wee1 kinase inhibition depends on homologous recombination repair.

实验应用 : ICC/IF

种属反应 : Human

Zhu J et al. Eur J Med Chem 2015; 96:196-208 Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.

种属反应 : Human

Waddell N et al. Nature 2015; 518 (7540):495-501 Whole genomes redefine the mutational landscape of pancreatic cancer.

种属反应 : Human

Beeharry N et al. Cell Cycle 2014; 13 (14):2172-91 Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints.

实验应用 : ICC/IF

种属反应 : Human

Sanjiv K et al. Transl Oncol 2014; 7 (2):256-266.e5 PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells.

实验应用 : WB

种属反应 : Human

Bhattacharjee V et al. Cell Cycle 2014; 13 (24):3839-56 a synthetic lethal screen identifies the vitamin d receptor as a novel * sensitizer in pancreatic cancer cells.

Uringa EJ et al. DNA Repair (Amst) 2014; 25C:27-40 A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.

实验应用 : ICC/IF

种属反应 : Mouse

White MK et al. PLoS One 2014; 9 (10):e110122 Rad51 Activates Polyomavirus JC Early Transcription.

实验应用 : WB

种属反应 : Human

Pefani DE et al. Nat Cell Biol 2014; RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

实验应用 : WB

种属反应 : Mouse

Karnak D et al. Clin Cancer Res 2014; Combined Inhibition of Wee1 and PARP1/2 for Radiosensitization in Pancreatic Cancer.

实验应用 : ICC/IF

种属反应 : Human

Naipal KA et al. Clin Cancer Res 2014; Functional ex vivo assay to select Homologous Recombination deficient breast tumors for PARP inhibitor treatment.

实验应用 : IHC-P

种属反应 : Human

Kaminski R et al. PLoS One 2014; 9 (5):e98304 Interplay of Rad51 with NF-κB Pathway Stimulates Expression of HIV-1.

实验应用 : ICC/IF

种属反应 : Human

Sanjiv K et al. Translational Oncology 2014; PI3K inhibition augments the therapeutic efficacy of a 3a-aza-cyclopenta[α]indene derivative in lung cancer cells

实验应用 : WB

种属反应 : Human

Jeyasekharan AD et al. Nat Struct Mol Biol 2013; 20 (10):1191-8 A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.

实验应用 : WB

种属反应 : Human

Helchowski CM et al. Cell Cycle 2013; 12 (24):3749-58 A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci.

实验应用 : ICC/IF

种属反应 : Human

Pfaffle HN et al. Cancer Res 2013; 73 (20):6254-63 EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.

实验应用 : ICC/IF

种属反应 : Human

Engelke CG et al. Clin Cancer Res 2013; 19 (16):4412-21 Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776.

实验应用 : ICC/IF

种属反应 : Human

Wei D et al. Clin Cancer Res 2013; 19 (16):4422-32 Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.

实验应用 : ICC/IF

种属反应 : Human

Zhu J et al. EMBO Mol Med 2013; 5 (3):353-65 A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.

实验应用 : WB

种属反应 : Human

Borst GR et al. Int J Radiat Oncol Biol Phys 2013; 85 (4):1110-8 Targeted radiosensitization by the Chk1 inhibitor SAR-020106.

实验应用 : ICC/IF

种属反应 : Human

Sharma S et al. Nucleic Acids Res 2012; 40 (2):682-91 REV1 and polymerase ζ facilitate homologous recombination repair.

实验应用 : ICC/IF

种属反应 : Human

Oplustilova L et al. Cell Cycle 2012; 11 (20):3837-50 Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.

实验应用 : ICC/IF

种属反应 : Human

Lee M et al. Oncogene 2011; 30 (30):533500 A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.

实验应用 : WB

种属反应 : Human

Klammer H et al. Cancer Res 2010; 70 (21):8498-506 Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells.

实验应用 : ICC/IF

Bowen C et al. Cancer Res 2010; 70 (8):3089-97 NKX3.1 activates cellular response to DNA damage.

实验应用 : ICC/IF

种属反应 : Human

Suzuki K et al. Nucleic Acids Res 2010; 38 (12):e129 A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks.

实验应用 : ICC/IF

种属反应 : Human

Ammazzalorso F et al. EMBO J 2010; 29 (18):3156-69 ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.

实验应用 : ICC/IF

Graeser M et al. Clin Cancer Res 2010; 16 (24):6159-68 A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.

实验应用 : ICC/IF

种属反应 : Human

Dungey FA et al. Mol Cancer Ther 2009; 8 (8):2243-54 Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90.

实验应用 : WB

种属反应 : Human

Carlessi L et al. Cell Death Differ 2009; 16 (6):795-806 DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression.

实验应用 : WB

种属反应 : Human

Warren M et al. Hum Mol Genet 2003; 12 (20):2645-56 Phenotypic effects of heterozygosity for a BRCA2 mutation.

实验应用 : ICC/IF

种属反应 : Chicken

Kao GD et al. J Cell Biol 2003; 160 (7):1017-27 Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.

实验应用 : ICC/IF

种属反应 : Human

Masson JY et al. EMBO J 1999; 18 (22):6552-60 The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.

实验应用 : WB

种属反应 : Human

SDS
PBS.pdf

产品包装	报价 (¥)
100 μl	¥ 4300
Qty

	(全国热线) 4006-800-892 / (深圳) 0755-26755892 / (北京) 010-88594029 / (上海) 021-34613729 / (广州) 18024516375 / (香港) +852-69410778
	http://www.neobioscience.com
	genetex@neobioscience.com

Rad51抗体 [14B4]

目录号 GTX70230

宿主

克隆

克隆编号

同种型

实验应用

种属反应

产品应用

应用说明

预期分子量

阳性对照

产品属性

形式

存储溶液

存放说明

浓度

免疫原种属

免疫原

纯化方式

偶联

RRID

注意事项

相关讯息

别名

细胞定位

功能与背景

数据库

研究领域

產品图片

GTX70230 IP Image

GTX70230 WB Image

GTX70230 WB Image

GTX70230 ICC/IF Image

GTX70230 ICC/IF Image

GTX70230 IHC-P Image

GTX70230 WB Image

GTX70230 WB Image

GTX70230 IHC Image

GTX70230 ICC/IF Image

GTX70230 WB Image

GTX70230 WB Image

GTX70230 WB Image

GTX70230 WB Image

GTX70230 WB Image

GTX70230 ICC/IF Image

GTX70230 ICC/IF Image

GTX70230 WB Image

GTX70230 ICC/IF Image

GTX70230 ICC/IF Image

GTX70230 IHC-P Image

GTX70230 WB Image

GTX70230 WB Image

GTX70230 WB Image

文献引用

Application Reference

产品评论

Rad51 antibody [14B4] 目录号 GTX70230

产品

研究

支持

公司

Follow Us

粤ICP备08007346号-9

© 1998-2022 GeneTex, Inc. 保留所有权利。

所有产品仅供研究使用 - 不应用于诊断或治疗。