产品说明
摘要
SARM1 antibody detects NAD(+) hydrolase SARM1, a key factor with a predicted molecular weight of ~79 kDa. SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration. SARM1 inhibition is being actively studied to prevent axonal degeneration associated with neurodegenerative disorders.
产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
实验应用 |
稀释倍数 |
1:500-1:3000 |
Assay dependent |
Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
预测种属反应
Rhesus Monkey(>80% identity)
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant protein encompassing a sequence within the C-terminus region of human SARM1. The exact sequence is proprietary.
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
RRID
AB_2909943
注意事项
仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
sterile alpha and TIR motif containing 1 , MyD88-5 , SAMD2 , SARM
细胞定位
Cytoplasm,Cell projection, dendrite,Cell junction, synapse,Mitochondrion
数据库
研究领域
產品图片
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GTX636097 WB Image
Mouse tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membranes were blotted with SARM1 antibody [HL1066] (GTX636097) diluted at 1:1000 and competitor's antibody (#Highly cited antibody) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
*The competitor is not affiliated with GeneTex and does not endorse this product.
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GTX636097 WB Image
Various tissue extracts (50 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with SARM1 antibody [HL1066] (GTX636097) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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GTX636097 ICC/IF Image
SARM1 antibody [HL1066] detects SARM1 protein by immunofluorescent analysis.Sample: SH-SY-5Y cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: SARM1 stained by SARM1 antibody [HL1066] (GTX636097) diluted at 1:500.Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:1000.Blue: Fluoroshield with DAPI (GTX30920).
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GTX636097 IHC-P Image
SARM1 antibody [HL1066] detects SARM1 protein at cytoplasm and mitochondria by immunohistochemical analysis.Sample: Paraffin-embedded mouse tissues.SARM1 stained by SARM1 antibody [HL1066] (GTX636097) diluted at 1:100.Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
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GTX636097 WB Image
Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with SARM1 antibody [HL1066] (GTX636097) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
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