形式
Liquid
存储溶液
1x TBS (pH7.4), 1% BSA, 40% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant protein
纯化方式
Protein A purified
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
SMAD family member 2 , JV18 , JV181 , MADH2 , MADR2 , SMAD2 , hMAD2 , hSMAD2 , Smad2
细胞定位
Cytoplasm,Nucleus
功能与背景
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
数据库
研究领域
![Anti-SMAD2 (phospho Ser250) antibody [SD207-1] used in Western Blot (WB). GTX01034](/upload/website/prouct_img/small/GTX01034/GTX01034_HL0103_20200214_WB_treatment_PMA_w_23053121_546.webp "Anti-SMAD2 (phospho Ser250) antibody [SD207-1] used in Western Blot (WB). GTX01034")
![Anti-SMAD2 (phospho Ser250) antibody [SD207-1] used in Flow cytometry (FACS). GTX01034](/upload/website/prouct_img/small/GTX01034/GTX01034_20200303_FACS_237_w_23053121_650.webp "Anti-SMAD2 (phospho Ser250) antibody [SD207-1] used in Flow cytometry (FACS). GTX01034")
![Anti-SMAD2 (phospho Ser250) antibody [SD207-1] used in Western Blot (WB). GTX01034](/upload/website/prouct_img/normal/GTX01034/GTX01034_HL0103_20200214_WB_treatment_PMA_w_23053121_546.webp "Anti-SMAD2 (phospho Ser250) antibody [SD207-1] used in Western Blot (WB). GTX01034")
![Anti-SMAD2 (phospho Ser250) antibody [SD207-1] used in Flow cytometry (FACS). GTX01034](/upload/website/prouct_img/normal/GTX01034/GTX01034_20200303_FACS_237_w_23053121_650.webp "Anti-SMAD2 (phospho Ser250) antibody [SD207-1] used in Flow cytometry (FACS). GTX01034")
