产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
预测种属反应
Mouse, Bovine, Chicken, Pig(>80% identity)
产品属性
形式
Liquid
存储溶液
PBS
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Carrier-protein conjugated synthetic peptide surrounding phospho Tyr705 of human STAT3. The exact sequence is proprietary.
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
signal transducer and activator of transcription 3 , ADMIO , ADMIO1 , APRF , HIES
细胞定位
Cytoplasm,Nucleus
功能与背景
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
数据库
研究领域
產品图片
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/templates/default/js/lightbox/images/loading.gif "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
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GTX636938 WB Image
Wild-type (WT) and STAT3 knockout (KO) HeLa cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with STAT3 (phospho Tyr705) antibody [HL1464] (GTX636938) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
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GTX636938 WB Image
Untreated (–) and treated (+) HeLa whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membranes were blotted with STAT3 (phospho Tyr705) antibody [HL1464] (GTX636938) diluted at 1:1000 and competitor's antibody (# Highly Cited Antibody) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
*The competitor is not affiliated with GeneTex and does not endorse this product.
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GTX636938 WB Image
Untreated (–) and treated (+) PC-12 whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with STAT3 (phospho Tyr705) antibody [HL1464] (GTX636938) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
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GTX636938 WB Image
Untreated (–) and treated (+) A549 whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with STAT3 (phospho Tyr705) antibody [HL1464] (GTX636938) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. (CIP: Calf-intestinal alkaline phosphatase)
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GTX636938 WB Image
Untreated (–) and treated (+) HeLa whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with STAT3 (phospho Tyr705) antibody [HL1464] (GTX636938) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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文献引用
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产品评论
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![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/small/GTX636938/GTX636938_44711_20220812_WB_KO_watermark_22081423_299.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/small/GTX636938/GTX636938_44711_20220923_WB_treatment_hIFN-alpha_competitor_watermark_22092622_785.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/small/GTX636938/GTX636938_44711_20220826_WB_R_treatment_hIFN-alpha_22083119_740.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/small/GTX636938/GTX636938_44711_20240119_WB_treatment_CIP_24012217_877.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/small/GTX636938/GTX636938_44711_20220617_WB_treatment_hIFN-alpha_22062121_876.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/normal/GTX636938/GTX636938_44711_20220812_WB_KO_watermark_22081423_299.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/normal/GTX636938/GTX636938_44711_20220923_WB_treatment_hIFN-alpha_competitor_watermark_22092622_785.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/normal/GTX636938/GTX636938_44711_20220826_WB_R_treatment_hIFN-alpha_22083119_740.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/normal/GTX636938/GTX636938_44711_20240119_WB_treatment_CIP_24012217_877.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
![Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938](/upload/website/prouct_img/normal/GTX636938/GTX636938_44711_20220617_WB_treatment_hIFN-alpha_22062121_876.webp "Anti-STAT3 (phospho Tyr705) antibody [HL1464] used in Western Blot (WB). GTX636938")
