形式
Liquid
存储溶液
1x TBS (pH7.4), 1% BSA, 40% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant protein
纯化方式
Protein A purified
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
stromal interaction molecule 1 , D11S4896E , GOK , IMD10 , STIM1 , STRMK , TAM , TAM1 , Stromal interaction molecule 1
细胞定位
Cell membrane,Endoplasmic reticulum membrane,Cytoplasm,Cytoskeleton
功能与背景
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
数据库
研究领域
![Anti-STIM1 antibody [SD0814] used in Western Blot (WB). GTX01149](/upload/website/prouct_img/small/GTX01149/GTX01149_HJ1017_20200228_WB_TPM_watermark_w_23053121_643.webp "Anti-STIM1 antibody [SD0814] used in Western Blot (WB). GTX01149")
![Anti-STIM1 antibody [SD0814] used in Western Blot (WB). GTX01149](/upload/website/prouct_img/normal/GTX01149/GTX01149_HJ1017_20200228_WB_TPM_watermark_w_23053121_643.webp "Anti-STIM1 antibody [SD0814] used in Western Blot (WB). GTX01149")
