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Somatostatin抗体 [SOM-018]

Anti-Somatostatin antibody [SOM-018] used in Immunohistochemistry (IHC). GTX71935
Anti-Somatostatin antibody [SOM-018] used in Immunohistochemistry (IHC). GTX71935
Anti-Somatostatin antibody [SOM-018] used in IHC (Frozen sections) (IHC-Fr). GTX71935
Anti-Somatostatin antibody [SOM-018] used in IHC (Frozen sections) (IHC-Fr). GTX71935

目录号 GTX71935

文献引用 45

宿主

 Mouse

克隆

 Monoclonal

克隆编号

 SOM-018

同种型

 IgG1

实验应用

 ICC/IF, IHC-P, IHC-Fr, IHC

种属反应

 Human, Mouse, Rat
产品包装
500 μl (¥5000)
查看所有 Somatostatin 的产品

产品应用

应用说明

Recommended Starting Dilutions:
For ICC/IF: Use at a dilution of 1:25-1:100
For IHC-Fr: Use at a dilution of 1:25-1:100
For IHC-P: Use at a dilution of 1:25-1:100
Not yet tested in other applications. Optimal dilutions should be determined experimentally by the researcher.

预期分子量

13 kDa. ( Note )

阳性对照

Pancreas

产品说明

The epitope recognised by this antibody lies within the Somatostatin-14.

产品属性

形式

Liquid

存储溶液

10mM PBS, 0.2% BSA

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

浓度

0.14 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Somatostatin conjugated to a protein carrier

纯化方式

Protein A affinity purified

偶联

Unconjugated

RRID

AB_383280

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

somatostatin , SMST

细胞定位

Secreted

功能与背景

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

数据库

研究领域

產品图片

Anti-Somatostatin antibody [SOM-018] used in Immunohistochemistry (IHC). GTX71935

GTX71935 IHC Image

The data was published in the journal Hippocampus in 2017. PMID: 27997999

Anti-Somatostatin antibody [SOM-018] used in Immunohistochemistry (IHC). GTX71935

GTX71935 IHC Image

The data was published in the journal Hippocampus in 2017. PMID: 27997999

Anti-Somatostatin antibody [SOM-018] used in IHC (Frozen sections) (IHC-Fr). GTX71935

GTX71935 IHC-Fr Image

The data was published in the journal J Neurosci in 2019.PMID: 30926750

Anti-Somatostatin antibody [SOM-018] used in IHC (Frozen sections) (IHC-Fr). GTX71935

GTX71935 IHC-Fr Image

The data was published in the journal J Neurosci in 2019.PMID: 30926750

文献引用

Application Reference

Kondabolu K et al. eNeuro 2023; 10 (7) A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.
Galer EL et al. J Neurosci 2023; 43 (3) : 419-432 Cervical Epidural Electrical Stimulation Increases Respiratory Activity through Somatostatin-Expressing Neurons in the Dorsal Cervical Spinal Cord in Rats.
实验应用 : IHC-Fr
种属反应 : Rat
Lukacs IP et al. Cereb Cortex 2023; 33 (5) : 2101-2142 Differential effects of group III metabotropic glutamate receptors on spontaneous inhibitory synaptic currents in spine-innervating double bouquet and parvalbumin-expressing dendrite-targeting GABAergic interneurons in human neocortex.
实验应用 : ICC/IF
种属反应 : Human
De-Fong Huang et al. 2022; 119 (33) Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons.
实验应用 : IHC-Fr
种属反应 : Mouse
Esi Domi et al. Sci Adv 2021; 7 (34) A neural substrate of compulsive alcohol use.
实验应用 : IHC
种属反应 : Rat
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Application Reference
Kondabolu K et al. eNeuro 2023; 10 (7) A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.
Galer EL et al. J Neurosci 2023; 43 (3):419-432 Cervical Epidural Electrical Stimulation Increases Respiratory Activity through Somatostatin-Expressing Neurons in the Dorsal Cervical Spinal Cord in Rats.
实验应用 : IHC-Fr
种属反应 : Rat
Lukacs IP et al. Cereb Cortex 2023; 33 (5):2101-2142 Differential effects of group III metabotropic glutamate receptors on spontaneous inhibitory synaptic currents in spine-innervating double bouquet and parvalbumin-expressing dendrite-targeting GABAergic interneurons in human neocortex.
实验应用 : ICC/IF
种属反应 : Human
De-Fong Huang et al. 2022; 119 (33) Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons.
实验应用 : IHC-Fr
种属反应 : Mouse
Esi Domi et al. Sci Adv 2021; 7 (34) A neural substrate of compulsive alcohol use.
实验应用 : IHC
种属反应 : Rat
Sato K et al. J Virol 2021; 95 (21):e0129621 TMPRSS2 Activates Hemagglutinin-Esterase Glycoprotein of Influenza C Virus.
实验应用 : IHC-Fr
种属反应 : Rat
Liu J et al. Front Neuroanat 2021; 15:662724 Molecular Characterization of Superficial Layers of the Presubiculum During Development.
Yamamoto T et al. Acta Histochem Cytochem 2020; 53 (5):121-129 The Chemokine CXCL14-like Immunoreactivity Co-exists with Somatostatin, but not NPY in the Rat Dorsal Horn and Has Intimate Association with GABAergic Neurons in the Lateral Spinal Nucleus.
Sato M et al. Cell Rep 2020; 32 (1):107864 Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.
Zhu JW et al. Cereb Cortex 2019; (Epub) Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling.
实验应用 : IHC-P
种属反应 : Mouse
Salib M et al. J Neurosci 2019; 39 (23):4527-4549 GABAergic Medial Septal Neurons with Low-Rhythmic Firing Innervating the Dentate Gyrus and Hippocampal Area CA3.
Nelson TS et al. Sci Rep 2019; 9 (1):7248 Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn.
实验应用 : IHC-Fr
种属反应 : Rat
Han P et al. Am J Transl Res 2019; 11 (3):1389-1402 Artemether ameliorates type 2 diabetic kidney disease by increasing mitochondrial pyruvate carrier content in db/db mice.
实验应用 : IHC-P
种属反应 : Human
Sato M et al. bioRxiv 2018; (Epub) Dynamic embedding of salience coding in hippocampal spatial maps.
实验应用 : IHC
Joshi A et al. Neuron 2017; 96 (6):1342-1357.e5 Behavior-Dependent Activity and Synaptic Organization of Septo-hippocampal GABAergic Neurons Selectively Targeting the Hippocampal CA3 Area.
种属反应 : Mouse
Okuyama T et al. Sci Rep 2017; 7 (1):2364 Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.
实验应用 : IHC-P
种属反应 : Mouse
Yuan M et al. Elife 2017; 6 Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition.
实验应用 : IHC
Liang T et al. J Biol Chem 2016; (Epub) new roles of syntaxin-1a in * granule exocytosis and replenishment.
实验应用 : ICC/IF
种属反应 : Mouse
Katona L et al. Hippocampus 2016; (Epub) Behavior-dependent activity patterns of GABAergic long-range projecting neurons in the rat hippocampus.
Damborsky JC et al. Brain Struct Funct 2016; Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin.
实验应用 : IHC-Fr
种属反应 : Mouse
Dolai S et al. Diabetes 2016; (Epub) synaptotagmin-7 functions to replenish * granules for exocytosis in human islet β-cell.
Bienvenu TC et al. J Neurosci 2015; 35 (5):2044-57 Large intercalated neurons of amygdala relay noxious sensory information.
Blodgett DM et al. Diabetes 2015; 64 (9):3172-81 Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.
Unal G et al. J Neurosci 2015; 35 (48):15812-26 Synaptic Targets of Medial Septal Projections in the Hippocampus and Extrahippocampal Cortices of the Mouse.
Orban-Kis K et al. Rom J Morphol Embryol 2015; 56 (1):155-61 The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus.
实验应用 : ICC/IF
种属反应 : Rat
Krasowska E et al. PLoS One 2014; 9 (9):e108364 Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy.
Maguire EP et al. J Neurosci 2014; 34 (3):823-38 Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants.
F. Aragon et al. Biochimica et Biophysica Acta (BBA) - General Subjects 2014; 1850 (2):343-351
实验应用 : ICC/IF
种属反应 : Mouse
Milenkovic I et al. Neuroscience 2013; 254:80-96 The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits alpha1, beta2, and delta along their extrasynaptic cell membrane.
实验应用 : ICC/IF
种属反应 : Mouse
Huang YC et al. Diabetes 2013; 62 (2):519-30
实验应用 : ICC/IF
种属反应 : Mouse
Somogyi J et al. Front Neural Circuits 2012; 6:35 Molecular analysis of ivy cells of the hippocampal CA1 stratum radiatum using spectral identification of immunofluorophores.
Chen CY et al. Hum Mol Genet 2012; 21 (19):4270-85 Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation.
实验应用 : IHC
种属反应 : Mouse
Hong ME et al. Korean J Physiol Pharmacol 2011; 15 (3):137-42 Influence of exposure to extremely low frequency magnetic field on neuroendocrine cells and hormones in stomach of rats.
Corteen NL et al. Eur J Neurosci 2011; 34 (2):250-62 Localization of GABA-A receptor alpha subunits on neurochemically distinct cell types in the rat locus coeruleus.
实验应用 : IHC
种属反应 : Rat
Huang YC et al. J Physiol 2011; 589 (Pt 2):395-408 Unperturbed islet α-cell function examined in mouse pancreas tissue slices.
实验应用 : IHC
种属反应 : Mouse
Lasztoczi B et al. J Neurosci 2011; 31 (49):18073-93 Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
实验应用 : ICC/IF
种属反应 : Rat
Romero-Zerbo SY et al. J Endocrinol 2011; 211 (2):177-85 A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.
Takahashi H et al. Appl Environ Microbiol 2011; 77 (19):6964-71 Role of indigenous lactobacilli in gastrin-mediated acid production in the mouse stomach.
实验应用 : IHC
种属反应 : Human
Matsuo T et al. Regul Pept 2010; 163 (43103):15919 Localization of neuroendocrine regulatory peptide-1 and-2 in human tissues.
实验应用 : IHC
种属反应 : Human
Fujita Y et al. Gastroenterology 2010; 138 (5):1966-75 glucose-dependent *otropic polypeptide is expressed in pancreatic islet alpha-cells and promotes * secretion.
实验应用 : IHC
Best L et al. Cell Physiol Biochem 2009; 23 (43196):255-64 Contrasting effects of glycerol and urea transport on rat pancreatic beta-cell function.
实验应用 : IHC-P
种属反应 : Rat
Liu F et al. J Neurosci 2009; 29 (16):5075-87 Brain injury does not alter the intrinsic differentiation potential of adult neuroblasts.
实验应用 : ICC/IF
种属反应 : Human
Panguluri S et al. Brain Res 2009; 1298:57-69 Comparison of somatostatin and corticotrophin-releasing hormone immunoreactivity in forebrain neurons projecting to taste-responsive and non-responsive regions of the parabrachial nucleus in rat.
实验应用 : IHC
种属反应 : Rat
Wolf-Goldberg T et al. Mol Pharmacol 2006; 70 (3):818-28 Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels.
实验应用 : IHC
种属反应 : Mouse
Leung YM et al. Endocrinology 2006; 147 (5):2155-62 * regulates islet alpha-cell function by reducing katp channel sensitivity to adenosine 5'-triphosphate inhibition.
实验应用 : ICC/IF
种属反应 : Human
SDS
Sodium Azide.pdf
产品包装 报价 (¥)
¥ 5000
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