形式
Liquid
存储溶液
PBS, 0.1% BSA
保存剂
0.02% Sodium azide
存放说明
Store the peptide at -20ºC, stable for one year.
浓度
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
Baculoviral Iap Repeat-Containing 5 , Aac-11 , Api4 , Tiap , Survivin40 , Birc5
功能与背景
Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2 / M phase of the cell cycle in a cycle regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin microtubule interactions results in loss of survivin's anti apoptosis function and increased caspase 3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2 / M phase. The over expression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.
研究领域
