产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预测种属反应
Mouse, Rat, Zebrafish, Dog, Pig, Xenopus tropicalis, Chimpanzee, Rhesus Monkey(>80% identity)
产品属性
形式
Liquid
存储溶液
PBS, 2% BSA
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
batch dependent
免疫原种属
Human
免疫原
Recombinant protein encompassing a sequence within the center region of human Thymidylate synthase. The exact sequence is proprietary.
纯化方式
Affinity purified by Protein A.
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
thymidylate synthetase ,HST422 ,TMS ,TS
细胞定位
Nucleus,Cytoplasm,Mitochondrion,Mitochondrion matrix,Mitochondrion inner membrane
功能与背景
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
数据库
研究领域
產品图片
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/templates/default/js/lightbox/images/loading.gif "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
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GTX639929 IHC-P Image
IHC-P analysis of human urinary bladder tissue using GTX639929 Thymidylate synthase antibody [HMV305] HistoMAX™.
Muscle-invasive urothelial carcinoma with moderate to strong TYMS staining of most tumor cells.
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GTX639929 IHC-P Image
IHC-P analysis of human thymus tissue using GTX639929 Thymidylate synthase antibody [HMV305] HistoMAX™.
Strong TYMS staining of a large fraction of lymphocytes.
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GTX639929 IHC-P Image
IHC-P analysis of human spleen tissue using GTX639929 Thymidylate synthase antibody [HMV305] HistoMAX™.
Moderate to strong TYMS staining of a fraction of lymphocytic cells.
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文献引用
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产品评论
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![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/small/GTX639929/GTX639929_20240403_IHC-P_2_24040301_930.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/small/GTX639929/GTX639929_20240403_IHC-P_24040301_377.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/small/GTX639929/GTX639929_20240403_IHC-P_1_24040301_669.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/normal/GTX639929/GTX639929_20240403_IHC-P_2_24040301_930.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/normal/GTX639929/GTX639929_20240403_IHC-P_24040301_377.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
![Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929](/upload/website/prouct_img/normal/GTX639929/GTX639929_20240403_IHC-P_1_24040301_669.webp "Anti-Thymidylate synthase antibody [HMV305] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX639929")
