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XRCC1抗体 [N1N3]

Anti-XRCC1 antibody [N1N3] used in IHC (Paraffin sections) (IHC-P). GTX111712
Anti-XRCC1 antibody [N1N3] used in Western Blot (WB). GTX111712
Anti-XRCC1 antibody [N1N3] used in Western Blot (WB). GTX111712
Anti-XRCC1 antibody [N1N3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX111712

目录号 GTX111712

文献引用 5

宿主

 Rabbit

克隆

 Polyclonal

同种型

 IgG

实验应用

 WB, ICC/IF, IHC-P

种属反应

 Human, Rat
产品包装
100 μl (¥4000),
25 μl (¥1700)
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产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认
实验应用 稀释倍数
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

69 kDa. ( Note )

阳性对照

293T , rat kidney

预测种属反应

Mouse, Dog(>80% identity)

产品属性

形式

Liquid

存储溶液

0.1M Tris, 0.1M Glycine, 10% Glycerol

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

0.73 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Recombinant protein encompassing a sequence within the center region of human XRCC1. The exact sequence is proprietary.

纯化方式

Purified by antigen-affinity chromatography.

偶联

Unconjugated

RRID

AB_1952603

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

X-ray repair cross complementing 1 , RCC , SCAR26

细胞定位

Nucleus

功能与背景

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]

数据库

研究领域

產品图片

Anti-XRCC1 antibody [N1N3] used in IHC (Paraffin sections) (IHC-P). GTX111712

GTX111712 IHC-P Image

Immunohistochemical analysis of paraffin-embedded SAS Xenograft , using XRCC1(GTX111712) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-XRCC1 antibody [N1N3] used in Western Blot (WB). GTX111712

GTX111712 WB Image

Rat tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with XRCC1 antibody [N1N3] (GTX111712) diluted at 1:500.

Anti-XRCC1 antibody [N1N3] used in Western Blot (WB). GTX111712

GTX111712 WB Image

Sample (30 ug of whole cell lysate)
A: 293T
7.5% SDS PAGE
GTX111712 diluted at 1:1000

Anti-XRCC1 antibody [N1N3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX111712

GTX111712 ICC/IF Image

Immunofluorescence analysis of paraformaldehyde-fixed A431, using XRCC1(GTX111712) antibody at 1:200 dilution.

文献引用

Application Reference

Islam A et al. Nucleic Acids Res 2024; 52 (5) : 2416-2433 Site-specific acetylation of polynucleotide kinase 3'-phosphatase regulates its distinct role in DNA repair pathways.
Chen SH et al. Sci Adv 2019; 5 (4) : eaav4340 Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies.
Valdez BC et al. Leuk Lymphoma 2017; : 43112 the parp inhibitor olaparib enhances the cytotoxicity of combined *, * and * in lymphoma cells.
实验应用 : WB
种属反应 : Human
Chakraborty A et al. Nat Commun 2016; 7 : 13049 Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes.
实验应用 : WB
种属反应 : Human
Nichole M. Owen et al. 0 2015; PARP inhibitor : abrogation of chromosomal radial-induced mitotic cell death and induction of multipolar division via loss of centrosome integrity.
实验应用 : ICC/IF
种属反应 : Human
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Glycerol.pdf
Thimerosal.pdf
产品包装 报价 (¥)
¥ 4000
¥ 1700
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