形式
Liquid
存储溶液
PBS, 10% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
The clone AT1D10 is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ACTN3 protein.
纯化方式
Protein A Purified
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
actinin alpha 1 , ACTN1 , BDPLT15 , alpha Actinin 1
细胞定位
Cytoplasm,Cytoskeleton,Myofibril,Sarcomere,Z line,Cell membrane,Cell junction,Cell projection,Ruffle
功能与背景
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
数据库
研究领域
![Anti-alpha Actinin 1 antibody [AT1D10] used in Western Blot (WB). GTX57633](/upload/website/prouct_img/small/GTX57633/GTX57633_20200204_WB_w_23061123_777.webp "Anti-alpha Actinin 1 antibody [AT1D10] used in Western Blot (WB). GTX57633")
![Anti-alpha Actinin 1 antibody [AT1D10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57633](/upload/website/prouct_img/small/GTX57633/GTX57633_20200204_IF_w_23061123_192.webp "Anti-alpha Actinin 1 antibody [AT1D10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57633")
![Anti-alpha Actinin 1 antibody [AT1D10] used in Flow cytometry (FACS). GTX57633](/upload/website/prouct_img/small/GTX57633/GTX57633_20200204_FC_w_23061123_726.webp "Anti-alpha Actinin 1 antibody [AT1D10] used in Flow cytometry (FACS). GTX57633")
![Anti-alpha Actinin 1 antibody [AT1D10] used in Western Blot (WB). GTX57633](/upload/website/prouct_img/normal/GTX57633/GTX57633_20200204_WB_w_23061123_777.webp "Anti-alpha Actinin 1 antibody [AT1D10] used in Western Blot (WB). GTX57633")
![Anti-alpha Actinin 1 antibody [AT1D10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57633](/upload/website/prouct_img/normal/GTX57633/GTX57633_20200204_IF_w_23061123_192.webp "Anti-alpha Actinin 1 antibody [AT1D10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57633")
![Anti-alpha Actinin 1 antibody [AT1D10] used in Flow cytometry (FACS). GTX57633](/upload/website/prouct_img/normal/GTX57633/GTX57633_20200204_FC_w_23061123_726.webp "Anti-alpha Actinin 1 antibody [AT1D10] used in Flow cytometry (FACS). GTX57633")
