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alpha Smooth Muscle Actin抗体 [1A4] (ready-to-use)

Anti-alpha Smooth Muscle Actin antibody [1A4] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX73419

目录号 GTX73419

文献引用 12

宿主

 Mouse

克隆

 Monoclonal

克隆编号

 1A4

同种型

 IgG2a

实验应用

 IHC-P, IHC-Fr, FACS

种属反应

 Human, Mouse, Rat
产品包装
6 ml (¥5600)
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产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认
实验应用 稀释倍数
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent

Note :

IHC-P
Recommendations for antigen retrieval : EDTA buffer pH 8.0 at room temperature for 30 mins.
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

42 kDa. ( Note )

产品说明

This antibody is specific to α-smooth muscle isoform of actin. It reacts with smooth muscle cells of vessels and different parenchymes. This antibody does not cross-react with β and γ-cytoplasmic, α-sarcomeric and α-myocardial actin isoforms.

产品属性

形式

Liquid

存储溶液

PBS

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

浓度

Batch dependent (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

BALB/C mice were injected with N-terminal decapeptide of α-smooth muscle actin.

纯化方式

Purified IgG

偶联

Unconjugated

RRID

AB_374897

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

actin alpha 2, smooth muscle , ACTSA

细胞定位

Cytoplasm, cytoskeleton

功能与背景

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]

数据库

  • Gene ID: 59 ACTA2
  • UniProt: P62736 ACTA2

研究领域

產品图片

Anti-alpha Smooth Muscle Actin antibody [1A4] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX73419

GTX73419 IHC-P Image

IHC-P analysis of human colon tissue using GTX73419 alpha Smooth Muscle Actin antibody [1A4] (ready-to-use).

文献引用

Application Reference

S Kecsk?s et al. Front Aging Neurosci 2023; 15 (1175281) Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia
实验应用 : IHC-Fr
种属反应 : Rat

Clone Reference

Zhou Z et al. Adv Sci (Weinh) 2023; 10 (23):e2300548 A T Cell-Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy.
P Bisaccia et al. Stem Cells Transl Med 2023;:szad070 Extracellular Vesicles From Mesenchymal Umbilical Cord Cells Exert Protection Against Oxidative Stress and Fibrosis in a Rat Model of Bronchopulmonary Dysplasia
Layton TB et al. Nat Commun 2020; 11 (1):2768 Cellular census of human fibrosis defines functionally distinct stromal cell types and states
实验应用 : FACS
种属反应 : Human
Medley SC et al. Wound Repair Regen 2020; Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair.
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Application Reference
S Kecsk?s et al. Front Aging Neurosci 2023; 15 (1175281) Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia
实验应用 : IHC-Fr
种属反应 : Rat
Varga DP et al. Neurobiol Dis 2020; 137:104780 The antagonism of prostaglandin FP receptors inhibits the evolution of spreading depolarization in an experimental model of global forebrain ischemia.
实验应用 : IHC-Fr
种属反应 : Rat
Clone Reference
Zhou Z et al. Adv Sci (Weinh) 2023; 10 (23):e2300548 A T Cell-Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy.
P Bisaccia et al. Stem Cells Transl Med 2023;:szad070 Extracellular Vesicles From Mesenchymal Umbilical Cord Cells Exert Protection Against Oxidative Stress and Fibrosis in a Rat Model of Bronchopulmonary Dysplasia
Layton TB et al. Nat Commun 2020; 11 (1):2768 Cellular census of human fibrosis defines functionally distinct stromal cell types and states
实验应用 : FACS
种属反应 : Human
Medley SC et al. Wound Repair Regen 2020; Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair.
Li DJ et al. Redox Biol 2018; 15:22-23 Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress.
实验应用 : IHC-P
种属反应 : Mouse
Wan W et al. Cardiovasc Res 2015; 106 (3):478-87 Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Gorchs L et al. Front Oncol 2015; 5:87 Cancer-Associated Fibroblasts from Lung Tumors Maintain Their Immunosuppressive Abilities after High-Dose Irradiation.
Aslani F et al. Hum Reprod 2015; 30 (2):417-31 Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis.
Akishima-Fukasawa Y et al. Am J Clin Pathol 2010; 134 (1):26177 Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma.
Backhouse S et al. Invest Ophthalmol Vis Sci 2010; 51 (12):6162-71 Effect of induced myopia on scleral myofibroblasts and in vivo ocular biomechanical compliance in the guinea pig.
SDS
PBS.pdf
Sodium Azide.pdf
产品包装 报价 (¥)
¥ 5600
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