alpha Tubulin抗体 [GT114]

Name: alpha Tubulin抗体 [GT114]
Brand: GeneTex
SKU: GTX628802
Price: 4000.00 RMB
Rating: 4 (2 reviews)

Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

Anti-alpha Tubulin antibody [GT114] used in IHC (Paraffin sections) (IHC-P). GTX628802

Anti-alpha Tubulin antibody [GT114] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX628802

Anti-alpha Tubulin antibody [GT114] used in IHC (Frozen sections) (IHC-Fr). GTX628802

目录号 GTX628802

文献引用 146

宿主	Mouse
克隆	Monoclonal
克隆编号	GT114
同种型	IgG2a
实验应用	WB, ICC/IF, IHC-P, IHC-Fr, FACS
种属反应	Human, Mouse, Rat, Zebrafish, Goat, Drosophila, Crucian carp
产品包装	100 μl (¥4000), 25 μl (¥1700)

查看所有 alpha Tubulin 的产品

View product citations for antibody GTX628802 on CiteAb

产品说明

摘要

alpha Tubulin antibody [GT114] detects alpha Tubulin, a cytoskeletal protein widely expressed in cells that is commonly used as a loading control for western blots. The predicted molecular weight of alpha Tubulin protein is 50 kDa. This is a well-cited mouse monoclonal antibody validated for multiple applications including western blot, immunohistochemistry, and immunocytochemistry.

产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认

实验应用	稀释倍数
WB	1:500-1:20000
ICC/IF	1:100-1:1000
IHC-P	1:100-1:1000
IHC-Fr	1:100-1:1000
FACS	Assay dependent

WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

50 kDa. ( Note )

阳性对照

293T , mouse brain , rat brain , zebrafish eye , PC-12 , Neuro2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12

预测种属反应

Rabbit, Bovine, Pig, Xenopus laevis, Chimpanzee, Rhesus Monkey(>80% identity)

产品属性

形式

Liquid

存储溶液

PBS, 20% Glycerol

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

1 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Recombinant protein encompassing a sequence within the center region of human alpha Tubulin. The exact sequence is proprietary.

纯化方式

Affinity purified by Protein A.
From tissue culture supernatant

偶联

Unconjugated

RRID

AB_2716636

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

别名

K-ALPHA-1 antibody , TUBA1B antibody , alpha-tubulin ubiquitous antibody , alpha tubulin antibody , tubulin K-alpha-1 antibody , tubulin alpha-ubiquitous chain antibody , tubulin , alpha , ubiquitous antibody , tubulin alpha-1B chain antibody , tubulin , alpha 1b antibody

功能与背景

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

研究领域

產品图片

GTX628802 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX628802 IHC-P Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein at cytoplasm in mouse colon by immunohistochemical analysis.
Sample: Paraffin-embedded mouse colon.
Red: alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:500.
Green: beta Catenin antibody [N1N2-2] (GTX101435) diluted at 1:500.
Blue: Hoechst 33342 staining.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

GTX628802 WB Image

alpha Tubulin antibody detects alpha Tubulin protein by western blot analysis. Varied amount of 293T Whole cell extracts was separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody (GTX628802) at a dilution of 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX628802 WB Image

Whole cell extract (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX628802 ICC/IF Image

TUBA1B antibody detects TUBA1B protein at Cytoskeleton by immunofluorescent analysis.
Sample: HeLa cells were fixed in -20ºC 100% methanol for 5 min.
Green: TUBA1B protein stained by TUBA1B antibody (GTX628802) diluted at 1:500.
Blue: Hoechst 33342 staining.

GTX628802 IHC-P Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein at cytoplasm in human lung cancer by immunohistochemical analysis.
Sample: Paraffin-embedded human lung cancer.
alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX628802 WB Image

GTX628802 IHC-Fr Image

Immunofluorescence photomicrographs of frozen sections of mouse brain.
Green: alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:200. The signal was developed using goat anti-rmouse IgG antibody (Dylight488) (GTX213111-04).
Blue: Nuclear staining with Hoechst 33342.

GTX628802 ICC/IF Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein expression by immunofluorescent analysis.
Sample: Cultured rat E18 primary cortical neuron, DIV 8. Cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: alpha Tubulin protein stained by alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:250.
Red: NeuN, stained by NeuN antibody (GTX132974) diluted at 1:250.
Blue: Fluoroshield with DAPI (GTX30920).

GTX628802 WB Image

alpha Tubulin antibody [GT114] detects TUBA1B protein by western blot analysis.
A. 30 μg 293T whole cell lysate/extract
B. 30 μg NIH-3T3 whole cell lysate/extract
C. 30 μg mouse brain lysate/extract
D. 30 μg PC-12 whole cell lysate/extract
E. 30 μg rat brain lysate/extract
F. 30 μg drosophila lysae/extract
10% SDS-PAGE
alpha Tubulin antibody [GT114] (GTX628802) dilution: 1:5000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX628802 WB Image

alpha Tubulin antibody [GT114] detects TUBA1B protein by western blot analysis.
A. 30 μg zebrafish eye lysate/extract
10% SDS-PAGE
alpha Tubulin antibody [GT114] (GTX628802) dilution: 1:1000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX628802 IHC-P Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein at cytoplasm in human cervix by immunohistochemical analysis.
Sample: Paraffin-embedded human cervix.
alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX628802 ICC/IF Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein at cytoskeleton by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: alpha Tubulin stained by alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:1000.
Blue: Fluoroshield with DAPI (GTX30920).

GTX628802 WB Image

293T whole cell extracts were separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

GTX628802 WB Image

The data was published in the journal Nat Commun in 2016.PMID: 27221592

GTX628802 WB Image

The data was published in the journal Life Sci Alliance in 2019.PMID: 31767615

GTX628802 WB Image

The data was published in the journal PLoS Biol in 2019.PMID: 30883547

GTX628802 WB Image

The data was published in the journal Biomolecules in 2020.PMID: 32635653

GTX628802 WB Image

The data was published in the journal Genome Biol in 2018.PMID: 29548335

GTX628802 WB Image

The data was published in the journal Biomolecules in 2020.PMID: 32635653

GTX628802 WB Image

The data was published in the journal PLoS One in 2017.PMID: 28467493

GTX628802 WB Image

The data was published in the journal J Cell Mol Med in 2020. PMID: 31821701

GTX628802 WB Image

The data was published in the journal Physiol Rep in 2017.PMID: 28408640

GTX628802 WB Image

The data was published in the journal Nat Commun in 2019.PMID: 31278365

GTX628802 WB Image

The data was published in the journal PLoS Biol in 2019.PMID: 30883547

GTX628802 WB Image

The data was published in the journal Genome Biol in 2018.PMID: 29548335

GTX628802 WB Image

The data was published in the journal Cell Biosci in 2019. PMID: 31044068

GTX628802 WB Image

The data was published in the journal Toxins (Basel) in 2019. PMID: 31159487

GTX628802 WB Image

The data was published in the journal Nat Commun in 2020. PMID: 32005813

GTX628802 WB Image

The data was published in the journal PLoS One in 2015. PMID: 25811469

GTX628802 WB Image

The data was published in the journal J Cell Mol Med in 2020. PMID: 31821701

GTX628802 WB Image

The data was published in the journal PLoS One in 2015. PMID: 25811469

GTX628802 WB Image

The data was published in the 2018 in Sci Rep. PMID: 30459446

GTX628802 WB Image

The data was published in the 2022 in Int J Mol Sci. PMID: 35055077

GTX628802 ICC/IF Image

The data was published in the 2018 in Sci Rep. PMID: 30459446

GTX628802 WB Image

The data was published in the 2022 in Int J Mol Sci. PMID: 35055077

GTX628802 WB Image

The data was published in the journal PLoS One in 2014. PMID: 25000307

文献引用

Application Reference

Liu B et al. PLoS One 2024; 19 (3) : e0296792 Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.

Wang X et al. Nat Commun 2024; 15 (1) : 2594 The aldehyde dehydrogenase 2 rs671 variant enhances amyloid β pathology.

Tsugami Y et al. Vet Res 2024; 55 (1) : 20 Effects of topical application of resveratrol on tight junction barrier and antimicrobial compound production in lactating goat mammary glands.

Y Jing et al. Cell Biol Toxicol 2024; 40 (1) : 2 Deficiency of copper responsive gene stmn4 induces retinal developmental defects

Toyoda JH et al. Int J Mol Sci 2023; 25 (1) Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells.

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产品评论

alpha Tubulin antibody [GT114] 目录号 GTX628802

Rating

( Average 4 based on 2 users reviews)

实验应用

Western Blot(WB)		( Average 5 based on 1 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)		( Average 3 based on 1 users reviews)

Date : Anonymous submitted on 08-Jun-2017

Score :

Application Tested : WB

Sample Species : Hu

Sample : SW480 cells

Amount used : 40 μg

Blocking : 5% milk in TBST, 25°C, 1Hr

Primary Antibody : 1:20000, 4°C, 16Hr

Date : Anonymous submitted on 24-Jun-2015

Score :

Application Tested : ICC/IF

Sample Species : Hu

Sample : U87-MG cells

Blocking : 5% BSA in PBST, 25°C, 2Hr

Fixation : 4% PFA

Primary Antibody : 1:200, 4°C, 16Hr

我要评论产品

Application Reference

Liu B et al. PLoS One 2024; 19 (3):e0296792 Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.

Wang X et al. Nat Commun 2024; 15 (1):2594 The aldehyde dehydrogenase 2 rs671 variant enhances amyloid β pathology.

Tsugami Y et al. Vet Res 2024; 55 (1):20 Effects of topical application of resveratrol on tight junction barrier and antimicrobial compound production in lactating goat mammary glands.

Y Jing et al. Cell Biol Toxicol 2024; 40 (1):2 Deficiency of copper responsive gene stmn4 induces retinal developmental defects

Toyoda JH et al. Int J Mol Sci 2023; 25 (1) Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells.

L Alvaro-Aranda et al. Nucleic Acids Res 2023;:gkad1222 The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination

S Kim et al. BMC Cancer 2023; 23 (1):1263 Endosulfine alpha maintains spindle pole integrity by recruiting Aurora A during mitosis

实验应用 : ICC/IF

Sun K et al. iScience 2023; 26 (11):108103 The splicing factor DHX38 enables retinal development through safeguarding genome integrity.

Schmidt S et al. Nat Commun 2023; 14 (1):7674 A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.

Bingbing L et al. J Tradit Chin Med 2023; 43 (5):906-914 Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway.

Tsugami Y et al. Innate Immun 2023; 29 (7):135-149 Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands.

MC Wu et al. PLoS One 2023; TAT peptide at treatment-level concentrations crossed brain endothelial cell monolayer independent of receptor-mediated endocytosis or peptide-inflicted barrier disruption

实验应用 : WB

F Ito et al. Nat Commun 2023; 14 (1):5241 Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H

实验应用 : WB

Niesen J et al. iScience 2023; 26 (9):107501 hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation.

Ozgencil M et al. Life Sci Alliance 2023; 6 (9) The linker histone H1-BRCA1 axis is a crucial mediator of replication fork stability.

SH Lu et al. Stem Cell Reports 2023; S2213-6711 (23):00184-4 Cardiac myofibrillogenesis is spatiotemporally modulated by the molecular chaperone UNC45B

实验应用 : WB

种属反应 : Human

Huang YH et al. Int J Mol Sci 2023; 24 (7) Src-FAK Signaling Mediates Interleukin 6-Induced HCT116 Colorectal Cancer Epithelial-Mesenchymal Transition.

实验应用 : WB

种属反应 : Human

Chang YW et al. Commun Biol 2023; 6 (1):427 Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface.

实验应用 : WB

种属反应 : Human

Tsugami Y et al. J Mammary Gland Biol Neoplasia 2023; 28 (1):3 Valine Treatment Enhances Antimicrobial Component Production in Mammary Epithelial Cells and the Milk of Lactating Goats Without Influencing the Tight Junction Barrier.

Moon SJ et al. Cancers (Basel) 2023; 15 (4) CTTN Overexpression Confers Cancer Stem Cell-like Properties and Trastuzumab Resistance via DKK-1/WNT Signaling in HER2 Positive Breast Cancer.

实验应用 : WB

种属反应 : Human

Song J et al. Curr Issues Mol Biol 2023; 45 (12):10193-10210 Hydrogen Attenuates Chronic Intermittent Hypoxia-Induced Cardiac Hypertrophy by Regulating Iron Metabolism.

Munk SHN et al. Nat Cell Biol 2023; 25 (12):1774-1786 NAD(+) regulates nucleotide metabolism and genomic DNA replication.

Liu CW et al. eNeuro 2022; 9 (5) Blood-Brain Barrier Disruption in Preclinical Mouse Models of Stroke Can Be an Experimental Artifact Caused by Craniectomy.

实验应用 : WB

种属反应 : Mouse

G?mez-Cabello D et al. Nat Commun 2022; 13 (1):5303 CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway.

Zheng Y et al. Front Cell Neurosci 2022; 16:989945 Decreased tubulin-binding cofactor B was involved in the formation disorder of nascent astrocyte processes by regulating microtubule plus-end growth through binding with end-binding proteins 1 and 3 after chronic alcohol exposure.

实验应用 : WB, ICC/IF

种属反应 : Mouse

Jeon SJ et al. J Biol Chem 2022; 298 (10):102464 Covalent conjugation of ubiquitin-like ISG15 to apoptosis-inducing factor exacerbates toxic stimuli-induced apoptotic cell death.

实验应用 : WB

种属反应 : Human

Tsugami Y et al. Front Immunol 2022; 13:941333 Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs.

实验应用 : WB

种属反应 : Goat

Bilkei-Gorzo O et al. EMBO J 2022; 41 (23):e108970 The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection.

Zheng Y et al. Brain Sci 2022; 12 (7) ERK1/2 Signalling Pathway Regulates Tubulin-Binding Cofactor B Expression and Affects Astrocyte Process Formation after Acute Foetal Alcohol Exposure.

Hsu MJ et al. Front Oncol 2022; 12:862326 Anti-Angiogenetic and Anti-Lymphangiogenic Effects of a Novel 2-Aminobenzimidazole Derivative, MFB.

Ji-Xian Song et al. Bioengineered 2022; 13 (4):8334-8348 Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice.

实验应用 : WB

种属反应 : Human, Mouse

Sophie Bachy et al. iScience 2022; 25 (2):103758 βig-h3-structured collagen alters macrophage phenotype and function in pancreatic cancer.

实验应用 : WB

种属反应 : Mouse

Mar?a Jos? Pe?a-G?mez et al. Int J Mol Sci 2022; 23 (2) XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxyuridine.

实验应用 : WB

种属反应 : Human, Mouse

Eliot Gougeon et al. JFMS Open Rep 2022; 8 (1):2.05512E+16 Myopathy with oval inclusions in a domestic shorthair cat.

实验应用 : WB

Song JX et al. Pharm Biol 2022; 60 (1):609-620 Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.

实验应用 : WB

种属反应 : Mouse

Hung YH et al. Am J Cancer Res 2022; 12 (2):713-728 Semaphorin 4C promotes motility and immunosuppressive activity of cancer cells via CRMP3 and PD-L1.

实验应用 : FACS

种属反应 : Human

Huang WY et al. J Neuroinflammation 2022; 19 (1):29 TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation.

实验应用 : WB

种属反应 : Mouse

Lu H.A. et al. Circ Res. 2022; 130 (1):112-129 Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner.

实验应用 : WB, ICC/IF

种属反应 : Human

Li Y et al. Bioengineered 2022; 13 (1):800-809 Sitagliptin ameliorates hypoxia-induced damages in endometrial stromal cells: an implication in endometriosis.

实验应用 : WB

种属反应 : Human

Tang YC et al. J Food Drug Anal 2021; 29 (4):638-652 A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells.

实验应用 : WB

种属反应 : Human

Gaetana Sessa et al. EMBO J 2021; 40 (7):e106018 BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair?.

实验应用 : WB

种属反应 : Human

Tognetti L et al. Photodermatol Photoimmunol Photomed 2021; Evaluation of 11-β hydroxysteroid dehydrogenase type 1 in cutaneous fibroblasts cultures of psoriatic lesional skin before and after narrow band-UVB phototherapy.

实验应用 : WB

Chen T et al. Blood Adv 2021; (Epub) Multiple Myeloma Cells Depend on the DDI2/NRF1-mediated Proteasome Stress Response for Survival.

实验应用 : WB

Vasarri M et al. Mar Drugs 2021; 19 (10) Posidonia oceanica (L.) Delile Dampens Cell Migration of Human Neuroblastoma Cells.

实验应用 : WB

种属反应 : Human

Fan SZ et al. Aging Cell 2021;:e13510 Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis.

实验应用 : WB

种属反应 : Drosophila

Lee TT et al. Aging Cell 2021; 20 (6):e13379 Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila.

实验应用 : WB

种属反应 : Drosophila

Wang SH et al. J Exp Clin Cancer Res 2021; 40 (1):95 Insulin-like growth factor binding protein 3 promotes radiosensitivity of oral squamous cell carcinoma cells via positive feedback on NF-κB/IL-6/ROS signaling.

实验应用 : WB

种属反应 : Human

Kiew LV et al. Biosens Bioelectron 2021; 183:113213 Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors.

实验应用 : WB

种属反应 : Human

Shu CW et al. Environ Toxicol 2021; 36 (6):1173-1180 Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells.

实验应用 : WB

Lai TH et al. J Reprod Immunol 2021; 145:103311 TGFβ1 induces in-vitro and ex-vivo angiogenesis through VEGF production in human ovarian follicular fluid-derived granulosa cells during in-vitro fertilization cycle.

Tsai YJ et al. J Clin Med 2021; 10 (3) Liver X Receptor Expression and Pentraxin 3 Production in Chronic Rhinosinusitis and Sinonasal Mucosal Fibroblast Cells.

实验应用 : WB

种属反应 : Human

You X et al. Mol Metab 2021; 48:101203 Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling.

实验应用 : WB

Wang HC et al. Int J Mol Sci 2021; 22 (5) Silencing DNA Polymerase β Induces Aneuploidy as a Biomarker of Poor Prognosis in Oral Squamous Cell Cancer.

实验应用 : WB

种属反应 : Human

Lam HYP et al. Parasitol Int 2021; 80:102231 Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain.

实验应用 : WB

种属反应 : Mouse

Wenting Xu et al. Front Bioeng Biotechnol 2020; 8:606496 A New Method for Chromosomes Preparation by ATP-Competitive Inhibitor SP600125 via Enhancement of Endomitosis in Fish.

实验应用 : ICC/IF

种属反应 : Crucian carp

Lin YH et al. Biomedicines 2020; 8 (11) ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects.

Lam HYP et al. Biomolecules 2020; 10 (7) Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.

Ehl?n ? et al. Nat Commun 2020; 11 (1):1819 Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.

Tsai LH et al. Sci Rep 2020; 10 (1):17817

实验应用 : WB

种属反应 : Human

Kometani T et al. Cancers (Basel) 2020; 12 (10) Increased Expression of NPM1 Suppresses p27^Kip1 Function in Cancer Cells.

实验应用 : WB

Wolfe AD et al. NAR Cancer 2020; 2 (4):zcaa027 The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.

实验应用 : WB

种属反应 : Human

Wang YY et al. PLoS Genet 2020; 16 (9):e1009020 Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.

Tsachaki M et al. Cell Mol Life Sci 2020; 77 (6):1153-1175 Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration.

Chi H et al. Sci Rep 2020; 10 (1):13482 Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model.

实验应用 : WB

种属反应 : Drosophila

Labus J et al. Prog Neurobiol 2020;:101900 Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor.

实验应用 : ICC/IF

种属反应 : Mouse

Patt M et al. Mol Cell Endocrinol 2020;:110873 Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211.

实验应用 : WB

种属反应 : Human

Mohapatra S et al. Cell Death Differ 2020; (Epub) Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver.

实验应用 : WB

Bogucka K et al. Elife 2020; 9 ERK3/MAPK6 controls IL-8 production and chemotaxis.

实验应用 : WB

种属反应 : Human

Tseng TL et al. Toxicol Appl Pharmacol 2020; 400:115070 OroxylinA reverses lipopolysaccharide-induced adhesion molecule expression and endothelial barrier disruption in the rat aorta.

实验应用 : ICC/IF

种属反应 : Rat

Chen PL et al. Nat Commun 2020; 11 (1):2592 Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.

实验应用 : WB

种属反应 : Drosophila

Lai YW et al. Sci Rep 2020; 10 (1):5132 Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain.

实验应用 : WB

种属反应 : Drosophila

Yang H et al. Nat Commun 2020; 11 (1):632 Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.

实验应用 : WB

种属反应 : Human

Huang SW et al. J Cell Mol Med 2020; 24 (2):1822-1836 Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade.

实验应用 : WB

种属反应 : Human

Chen TI et al. J Virol 2019; 93 (22) Hepatitis C Virus NS3 Protein Plays a Dual Role in WRN-Mediated Repair of Nonhomologous End Joining.

Lieschke S et al. Cells 2019; 9 (1) CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age.

实验应用 : WB

种属反应 : Mouse

Zhu Z et al. Life Sci Alliance 2019; 2 (6) The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.

实验应用 : WB

种属反应 : Mouse

Zhang J et al. BMC Cancer 2019; 19 (1):921 Lentivirus-mediated CDglyTK gene-modified free flaps by intra-artery perfusion show targeted therapeutic efficacy in rat model of breast cancer.

实验应用 : WB

种属反应 : Human

Teng LL et al. PLoS Biol 2019; 17 (3):e2007097 Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.

Chang HW et al. Toxins (Basel) 2019; 11 (6) Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells.

Chang CC et al. Nat Commun 2019; 10 (1):4307 Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α.

实验应用 : ICC/IF

种属反应 : Human

Karki A et al. Oncol Rep 2019; MDM4 expression in fibrolamellar hepatocellular carcinoma.

Lien JC et al. Br J Pharmacol 2019; A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti- angiogenesis effects via targeting VEGFR-2 signaling.

Chuang WT et al. J Agric Food Chem 2019; 67 (25):7136-7146 Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet.

实验应用 : WB

种属反应 : Mouse

Liao KH et al. Brain Res 2019;:146320 Carbogen inhalation opens the blood-brain barrier in rats without causing long-term metabolic or neurological deficit.

实验应用 : WB

种属反应 : Rat

Kikuma K et al. Nat Commun 2019; 10 (1):2998 Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling.

实验应用 : WB

种属反应 : Drosophila

Sonia L. Evagelou et al. bioRxiv 2019; (Epub) DEAD-box protein family member DDX28 is a negative regulator of HIF-2α and eIF4E2-directed hypoxic translation.

实验应用 : WB

种属反应 : Human

Ma Z et al. Cell Biosci 2019; 9:34 Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis.

实验应用 : WB

种属反应 : Human

Alard A et al. Front Genet 2019; 10:254 Differential Regulation of the Three Eukaryotic mRNA Translation Initiation Factor (eIF) 4Gs by the Proteasome.

实验应用 : WB

种属反应 : Mouse

Tsachaki M et al. FASEB J 2018; 32 (5):2690-2705 Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance.

Galanos P et al. Genome Biol 2018; 19 (1):37 Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Shieh JM et al. J Cell Physiol 2018; (Epub) TGFβ mediates collagen production in human CRSsNP nasal mucosa-derived fibroblasts through Smad2/3-dependent pathway and CTGF induction and secretion.

实验应用 : WB

种属反应 : Human

Walch L et al. Sci Rep 2018; 8 (1):17121 GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.

实验应用 : WB

种属反应 : Human

Koto Kikuma et al. bioRxiv 2018; (Epub) The sleep gene insomniac ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling.

实验应用 : WB

种属反应 : Drosophila

Zhang D et al. Med Sci Monit 2018; 24:6666-6672 mitochondrial dynamics in rat heart induced by 5-*.

实验应用 : WB

种属反应 : Rat

Sun Y et al. Int J Oncol 2018; (Epub) identification of * sensitizers through high-throughput combinatorial screening.

Maya-Mendoza A et al. Nature 2018; 559 (7713):279-284 High speed of fork progression induces DNA replication stress and genomic instability.

实验应用 : WB

种属反应 : Human

Irene Vorontsova et al. iOVS 2018; 59 (7) Aqp0a Regulates Suture Stability in the Zebrafish Lens.

实验应用 : WB

种属反应 : Zebrafish

Yu-Lee LY et al. Cancer Res 2018; (Epub) Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway.

实验应用 : WB

种属反应 : Human

Macdougall CE et al. Cell Metab 2018; 27 (3):588-601.e4 Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.

实验应用 : WB

种属反应 : Mouse

Wilkie AR et al. J Virol 2018; (Epub) A role for myosin Va in human cytomegalovirus nuclear egress.

实验应用 : WB

种属反应 : Human

Sivarapatna A et al. Cell Transplant 2017; 26 (8):1365-1379 Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Chang CW et al. Stem Cell Res 2017; 27:21-24 Generation of FHL2 homozygous knockout lines from human embryonic stem cells by CRISPR/Cas9-mediated ablation.

实验应用 : WB

种属反应 : Human

Wu LH et al. J Cell Physiol 2017; (Epub) Laminar Shear Stress Promotes Mitochondrial Homeostasis in Endothelial Cells.

实验应用 : WB

种属反应 : Human

Su CY et al. Eur J Pharm Biopharm 2017; Development and Characterization of Docetaxel-Loaded Lecithin-Stabilized Micellar Drug Delivery System (L_sbMDDs) for Improving the Therapeutic Efficacy and Reducing Systemic Toxicity.

Huang SC et al. EMBO Mol Med 2017; (Epub) TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB.

实验应用 : WB

种属反应 : Human

Lee YC et al. Int J Mol Sci 2017; 18 (9) Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2.

实验应用 : WB

种属反应 : Human

Groussaud D et al. PLoS Pathog 2017; 13 (7):e1006518 Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription.

实验应用 : WB

种属反应 : Human

Xiao X et al. Nucleic Acids Res 2017; (Epub) Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.

实验应用 : WB

种属反应 : Human

Eshima H et al. Am J Physiol Regul Integr Comp Physiol 2017;:ajpregu.00032.2017 Improved skeletal muscle Ca²⁺ regulation in vivo following contractions in mice overexpressing PGC-1α.

实验应用 : WB

种属反应 : Mouse

Eshima H et al. Physiol Rep 2017; 5 (7) Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle.

实验应用 : WB

种属反应 : Mouse

Willkomm L et al. PLoS One 2017; 12 (5):e0176609 p38 MAPK activation and H3K4 trimethylation is decreased by lactate in vitro and high intensity resistance training in human skeletal muscle.

实验应用 : WB

Yang CH et al. Arch Virol 2017; (Epub) Influenza A virus upregulates PRPF8 gene expression to increase virus production.

Huang WY et al. J Dermatol Sci 2017; (Epub) Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction.

实验应用 : WB

种属反应 : Rat

Gan Z et al. Cell Syst 2016; 3 (3):252-263.e8 Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration.

实验应用 : WB

种属反应 : Human

Selagea L et al. FASEB J 2016; 30 (12):4098-4108 EGFR and C/EBP-β oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-β isoform.

实验应用 : WB

种属反应 : Human

Or CR et al. Int J Mol Sci 2016; 18 (1) Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells.

实验应用 : WB

种属反应 : Human

Wang SH et al. Med Mycol 2016; (Epub) Induction of cyclooxygenase-2 gene by Candida albicans through EGFR, ERK, and p38 pathways in human urinary epithelium.

实验应用 : WB

种属反应 : Human

Funghi L et al. Mol Cell Endocrinol 2016; 437:163-170 Expression and regulation of 11β-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia.

实验应用 : WB

种属反应 : Human

Peng YJ et al. Sci Rep 2016; 6:32444 Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.

实验应用 : WB

种属反应 : Human

Chang KH et al. CNS Neurosci Ther 2016; The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1.

实验应用 : WB

种属反应 : Human

Yamamoto K et al. Peptides 2016; 82:120-7 Contrasting effects of stanniocalcin-related polypeptides on macrophage foam cell formation and vascular smooth muscle cell migration.

Won SJ et al. J FUNCT FOODS 2016; 24:568-578 A novel natural tautomeric pair of garcinielliptone FC suppressed nuclear factor κB and induced apoptosis in human colorectal cancer cells.

实验应用 : WB

种属反应 : Human

Weng C et al. J Biol Chem 2016; (Epub) miRNA-342 regulates CEACAM1-induced lumen formation in a 3D model of mammary gland morphogenesis.

实验应用 : WB

种属反应 : Human

Kwon HJ et al. Nat Commun 2016; 7:11686 Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition.

实验应用 : WB

种属反应 : Human

Choe KN et al. EMBO Rep 2016; (Epub) HUWE1 interacts with PCNA to alleviate replication stress.

实验应用 : WB

种属反应 : Human

Lu JW et al. Cancer Lett 2016; (Epub) * is selectively cytotoxic in acute myeloid leukemia cells with flt3-internal tandem duplication (flt3-itd).

实验应用 : WB

种属反应 : Human

Wang C et al. PLoS One 2015; 10 (3):e0120913 combining * with abt-263 has a synergistic effect on * resistant prostate cancer cells.

实验应用 : WB

种属反应 : Human

Bettens K et al. Mol Neurodegener 2015; 10:30 Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.

实验应用 : WB

种属反应 : Human

Chuang YF et al. PLoS One 2015; 10 (8):e0137177 Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells.

实验应用 : WB

种属反应 : Mouse

Chen WL et al. PLoS One 2015; 10 (9):e0137979 Mycobacterium tuberculosis Upregulates TNF-α Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells.

实验应用 : WB

种属反应 : Human

Tsai KN et al. J Virol 2015; 89 (22):11406-19 Doubly Spliced RNA of Hepatitis B Virus Suppresses Viral Transcription via TATA-Binding Protein and Induces Stress Granule Assembly.

实验应用 : WB

种属反应 : Human

Huang YH et al. Sci Rep 2015; 5:15900 The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death.

实验应用 : WB

种属反应 : Human

Khalil H et al. J Cell Sci 2015; 128 (18):3502-13 The caspase-3-p120-RasGAP module generates a NF-κB repressor in response to cellular stress.

Davide P et al. Cell Mol Gastroenterol Hepatol 2015; 1 (6):646-663 Lipid-Induced Hepatocyte-Derived Extracellular Vesicles Regulate Hepatic Stellate Cells via MicroRNA Targeting Peroxisome Proliferator-Activated Receptor γ.

实验应用 : WB

种属反应 : Human

Naik NG et al. J Virol 2015; 89 (13):6746-60 Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication.

实验应用 : WB

种属反应 : Human

Satow R et al. Proc Natl Acad Sci U S A 2014; 111 (37):13505-10 Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells.

实验应用 : WB

种属反应 : Human

Chang LC et al. Br J Pharmacol 2014; 171 (17):4010-25 YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK.

实验应用 : WB

种属反应 : Human

Pitts RJ et al. Proc Natl Acad Sci U S A 2014; 111 (7):2566-71 Odorant receptor-mediated sperm activation in disease vector mosquitoes.

Li KC et al. Mol Cancer 2014; 13:172 Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma.

实验应用 : WB

种属反应 : Human

Lin TY et al. PLoS One 2014; 9 (7):e101980 Hypoxia-Inducible Factor 2 Alpha Is Essential for Hepatic Outgrowth and Functions via the Regulation of leg1 Transcription in the Zebrafish Embryo.

实验应用 : WB

种属反应 : Zebrafish

Emhemmed F et al. Biochem Pharmacol 2014; Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.

实验应用 : WB

种属反应 : Human

Chu TH et al. J Virol 2014; 88 (5):2530-43 Nucleic Acid chaperone activity associated with the arginine-rich domain of human hepatitis B virus core protein.

实验应用 : WB

种属反应 : Human

Bailey CC et al. J Biol Chem 2013; 288 (45):32184-93 Interferon-induced transmembrane protein 3 is a type ii transmembrane protein.

实验应用 : ICC/IF

Eshima H et al. Am J Physiol Regul Integr Comp Physiol 2013; 305 (6):R610-8 In vivo imaging of intracellular Ca2+ after muscle contractions and direct Ca2+ injection in rat skeletal muscle in diabetes.

实验应用 : WB

种属反应 : Rat

Clone Reference

Waller V et al. Front Oncol 2023; 13:1117326 The role of EphA2 in ADAM17- and ionizing radiation-enhanced lung cancer cell migration.

Monta??s-Agudo P et al. J Cell Sci 2021; Inhibition of minor intron splicing reduces Na+ and Ca2+ channel expression and function in cardiomyocytes.

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