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beta Amyloid (1-42)抗体 – Conformation Specific

Comparison Orthogonal
Anti-beta Amyloid (1-42) antibody – Conformation Specific used in ELISA (ELISA). GTX134510
Anti-beta Amyloid (1-42) antibody – Conformation Specific used in ELISA (ELISA). GTX134510
Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510
Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510
Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510
Anti-beta Amyloid (1-42) antibody – Conformation Specific used in Dot blot (Dot). GTX134510
Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510

目录号 GTX134510

文献引用 5
1

宿主

 Rabbit

克隆

 Polyclonal

同种型

 IgG

实验应用

 IHC-P, Dot, ELISA, Neutralizing/Inhibition, Sandwich ELISA

种属反应

 Human, Mouse
产品包装
100 μl (¥4000),
25 μl (¥1700)
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产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认
实验应用 稀释倍数
IHC-P 1:100-1:1000
Dot Assay dependent
ELISA 1:1000-1:10000
Neutralizing/Inhibition Assay dependent
Sandwich ELISA Assay dependent

Note :

Sandwich ELISA
Capture : GTX635160, Detection: GTX134510
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

87 kDa. ( Note )

产品说明

This antibody specifically recognizes beta amyloid aggregates but not peptide monomers.

预测种属反应

Rat, Rabbit, Bovine, Dog, Chicken, Pig, Xenopus tropicalis, Chimpanzee(>80% identity)

产品属性

形式

Liquid

存储溶液

PBS, 1% BSA, 20% Glycerol

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

0.45 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

The immunogen used to generate this antibody corresponds to human Beta amyloid (1-42)

纯化方式

Purified by antigen-affinity chromatography.

偶联

Unconjugated

RRID

AB_2887299

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

amyloid beta precursor protein , AAA , ABETA , ABPP , AD1 , APPI , CTFgamma , CVAP , PN-II , PN2 , preA4

细胞定位

Cell membrane,Membrane,Cytoplasmic vesicle,Cytoplasm

功能与背景

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

数据库

研究领域

產品图片

Anti-beta Amyloid (1-42) antibody – Conformation Specific used in ELISA (ELISA). GTX134510

GTX134510 ELISA Image

Sandwich ELISA detection of beta Amyloid (1-42)–peptide aggregate using GTX635160 as capture antibody at concentration of 10 μg/mL and GTX134510 as detection antibody at concentration of 0.45 μg/mL. Rabbit IgG antibody (HRP) (GTX213110-01) was diluted at 1:2000 and used to detect the primary antibody.

Anti-beta Amyloid (1-42) antibody – Conformation Specific used in ELISA (ELISA). GTX134510

GTX134510 ELISA Image

ELISA plate is coated with 100 μL of beta Amyloid (1-42) peptide aggregate at 10 μg/mL. The coated protein is detected with beta Amyloid (1-42) antibody – Conformation Specific (GTX134510) at concentrations ranging from 45 ng/mL down to 1.67 ng/mL.

Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510

GTX134510 IHC-P Image

Orthogonal

Beta amyloid (1-42) antibody (conformation specific) detects beta amyloid protein aggregates by immunohistochemical analysis in the hippocampus of 3xTg-AD transgenic mouse brain (left), but not in age- and gender- matched normal mouse brain (right).
Sample: Paraffin-embedded 3xTg-AD transgenic mouse brain (left) and healthy mouse brain (right).
beta Amyloid (1-42) stained by beta Amyloid (1-42) antibody – Conformation Specific (GTX134510) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0
This image was provided courtesy of a customer review.

Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510

GTX134510 IHC-P Image

Comparison

Conformation-specific beta amyloid antibody detects beta amyloid protein aggregates in the occipital lobe of human Alzheimer's disease brain by immunohistochemical analysis.
Antibodies: beta amyloid (1-42) antibody – Conformation Specific (GTX134510) diluted at 1:500, and competitor's antibody diluted at 1:500.

*Competitor's antibody is not affiliated with GeneTex and does not endorse this product.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510

GTX134510 IHC-P Image

Orthogonal

Beta amyloid (1-42) antibody (conformation specific) detects beta amyloid protein aggregates by immunohistochemical analysis in the occipital lobe of Alzheimer's disease brain (left), but not in normal human brain(right).
Sample: Paraffin-embedded Human Brain (Alzheimer's Disease + Normal) tissue slides (GTX49382).
beta amyloid protein aggregates stained by beta amyloid (1-42) antibody – Conformation Specific (GTX134510) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-beta Amyloid (1-42) antibody – Conformation Specific used in Dot blot (Dot). GTX134510

GTX134510 Dot Image

Dot blot analysis of 200ng beta amyloid peptide (1-42) oligomers or monomers, using Beta amyloid (1-42) antibody – Conformation Specific (GTX134510) diluted at 1:4000, 1:8000, and 1:16000.

Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510

GTX134510 IHC-P Image

Comparison

Conformation-specific beta amyloid antibody detects beta amyloid protein aggregates in the postcentral gyrus of human Alzheimer's disease brain by immunohistochemical analysis.
Antibodies: beta amyloid (1-42) antibody – Conformation Specific (GTX134510) diluted at 1:500, and competitor's antibody diluted at 1:500.

*Competitor's antibody is not affiliated with GeneTex and does not endorse this product.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

文献引用

Application Reference

Tammaro A et al. iScience 2024; 27 (1) : 108681 HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice.
Yang Y et al. Front Aging Neurosci 2023; 15 : 1126273 A single dose of lipopolysaccharide elicits autofluorescence in the mouse brain.
种属反应 : Mouse
Amano A et al. J Nanobiotechnology 2023; 21 (1) : 36 Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain.
实验应用 : Neutralizing/Inhibition
Wang H et al. CNS Neurosci Ther 2021; (Epub) Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease.
实验应用 : IHC-P
种属反应 : Mouse
Dinkel F et al. Front Aging Neurosci 2020; 12 : 220 Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer's Disease Patients.
实验应用 : IHC-P
种属反应 : Human
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产品评论

beta Amyloid (1-42) antibody – Conformation Specific 目录号 GTX134510

Rating
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实验应用
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 1 users reviews)
Anti-beta Amyloid (1-42) antibody – Conformation Specific used in IHC (Paraffin sections) (IHC-P). GTX134510
Date : Anonymous submitted on 10-Sep-2018
Score :
Application Tested : IHC-P
Sample Species : Ms
Sample : Hippocampus
Primary Antibody : 1:500, 4°C, 16Hr
我要评论产品
SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
产品包装 报价 (¥)
¥ 4000
¥ 1700
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